ShootsFruitsAndLeaves
Wrt 5a RD, the AR gene is located on the one of the autosomal chromosomes isn't it, not on the sex chromosomes X or Y. It is autosomal recessive. So, women can also inherit one or even theoretically two copies of this mutated gene, but don't suffer any consequences as the development of female sex characteristics is not dependent on it. Males are, so a deficiency of dihydrotestosterone prevents the full masculinisation of male genitals in utero.
I suppose it is obvious when the testes (despite being internal) has kicked up production of testosterone for male puberty. As is perfectly healthy in males. Even when there has been a difficulty with the formation of the sex characteristics in utero. Of course, women don't have testes for this huge kick of testosterone production. Only much smaller production by the ovaries (and by both sexes in adrenal glands).
Interestingly, even this much lower level that occur in a healthy woman's body is quickly converted to oestrogen.
Most females don’t develop male characteristics because testosterone and other androgens act differently in their bodies, being quickly converted to estrogen.
There is an issue only when there is some underlying problem, However, when female bodies produce an excess amount of testosterone or other androgens, their bodies can’t keep up with converting it to estrogen.
Again though, there is good news for those males who have this condition Most affected individuals are unable to have biological children without assisted reproduction . So with assisted reproduction, the male gametes, sperm, may be extracted and they may have biological children.
Inheritance Pattern
Although people who are genetically female (with two X chromosomes in each cell) may inherit mutations in both copies of the SRD5A2 gene, their sexual development is not affected.The development of female sex characteristics does not require DHT, so a lack of steroid 5-alpha reductase 2 activity does not cause physical changes in these individuals.
jim.bmj.com/content/54/1/S259.3
www.healthline.com/health/womens-health/do-women-have-testosterone
ps. I make sure I look at more than Wiki now. Although I admit I also go for a quick gander.