South Coast of course! Plenty of airports to choose from (Gatwick, Heathrow, Southampton, Bournemouth), good rail links to London (and other places of course), lovely countryside and equally lovely seaside.
I have to live here for work but I love it here and I can't see myself ever moving. There is something really quite wonderful about just getting up and going to the beach, even on a wintry day. It's lovely to go for a walk, breathe in the sea air and then sometimes even go to the arcade
. DH and I had a great evening in there playing on the 2p machines 
Lots to do on your doorstep - the New Forest, Paultons Park, villages to go and explore, the seaside (have I mentioned that?!), ferries to France and beyond, I could go on. I will infact, if you PM me :-P
One of the main things I love about living here is (and this sounds daft) you're never that far from a motorway. I live in a reasonably quiet village and the motorway is 5-7 minutes drive. That's it. I'm then connected to two major cities and obviously, further afield. Most people I know down here live a maximum of 10-15 minutes away from a motorway.
In all seriousness, it's important that you choose somewhere that suits you. For me, having family close by is important. I need the support network, even if my mother is a fruitloop. I like living in a village because it is easy to make friends (DH and I are not good at making friends yet we seem to have made loads of them in 4 years of living here!). The only thing that puts me off living here at the moment is whilst the primary schools are good, the feeder senior isn't. BUT I don't even have children yet & that could all change so I'm not too worried about that at the moment.
Happy to chat more about the joys of South Coast living, you know where I am
x