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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

What dose of MJ was the highest you could tolerate?

36 replies

CloudyYellow · 04/01/2026 18:46

I have lost 3.5 stone since starting in July. Every time I have gone up a dose I have done it slowly in increments. However, 7mg for 2 weeks followed.by 7.5 mg and food noise is back and don't feel great.

I am thinking of going to 6 or 6.5 mg today. Anyone else done this or did you continue on dose/going up doses?

I have another 2 stone to lose....

OP posts:
PermanentTemporary · 04/01/2026 18:48

I don’t quite understand your post. But I’m currently back up at 12.5 having stepped back to 10 for months after a really bad time at 15. I don’t feel wonderful today but it’s ok. Hoping to stick to this for a while.

CloudyYellow · 04/01/2026 18:53

Sorry I did 2.5 for a month then slowly titrated up to 5mg then 5.5 mg, 6mg. 6.5 mg. 7mg then 7.5 mg...

OP posts:
Mounraine · 04/01/2026 18:56

4mg 🫣

JennyForeigner · 04/01/2026 18:56

5mg. I lost weight like the clappers but felt dreadful and 7.5mg was completely unmanageable. I went back down to 5 but felt the best balance was actually 2.5mg. I gave up as soon as I got near my target weight but regretted it as I am one of the ADHD people who found it unexpectedly helpful in other ways.

I'm trying wegovy now and having had anything like the sickness so now feel a bit of an idiot for not trying a switch earlier.

Puddingpiper · 04/01/2026 19:02

I have not gone above 5mg (9 months and 6 stone lighter)

JMSA · 04/01/2026 19:02

I’m on 15 but could easily manage a 3 course meal. I’ve never had total suppression.

JBJ · 04/01/2026 19:10

I got up to 10mg but the constipation was horrendous and I was having to eat 40g plus of fibre per day to keep it manageable, which is challenging with a reduced appetite! I’ve dropped back down now as I can manage on a lower dose.

Gettingbysomehow · 04/01/2026 19:15

I went up to 10mgs and felt like death. Back down to 7.5mgs which suits me the best. I need to lose another half stone.

Carzycat · 04/01/2026 19:26

I kept getting really bad diarrhoea at 7.5mg (but not all the time) so dropped back to 5mg. I switched to Wegovy for awhile and am back on my first2.5mg pen now.
if I wasn’t working I’d probably have persevered but I didn’t want to take time off sick.

IndieRocknRoll · 04/01/2026 19:52

7.5 but I’d reached my goal at this point.
i did find though that the suppression etc wore off quicker with each dose, it was like I’d started to become immune to it!

ShawnaMacallister · 04/01/2026 19:54

I got to 15mg in order to get to target with no issues and I'm currently maintaining at 12.5 but with the aim of moving down slowly. Why are you planning to reduce your dose if food noise is coming back?

CloudyYellow · 04/01/2026 22:40

ShawnaMacallister · 04/01/2026 19:54

I got to 15mg in order to get to target with no issues and I'm currently maintaining at 12.5 but with the aim of moving down slowly. Why are you planning to reduce your dose if food noise is coming back?

Unfortunately I am not feeling great on 7.5 mg. Still working out what I should do as been tempted to stop MJ as really feeling not great.

OP posts:
Puddingpiper · 04/01/2026 22:41

@CloudyYellowwhat dose did you last feel ok on? I would be tempted to go back to that one? Personally by body likes 3.75 which is 45 clicks of a 5mg pen

CloudyYellow · 04/01/2026 23:19

Puddingpiper · 04/01/2026 22:41

@CloudyYellowwhat dose did you last feel ok on? I would be tempted to go back to that one? Personally by body likes 3.75 which is 45 clicks of a 5mg pen

I think 6 mg was my sweet spot. I seemed to get more food noise on 7 and 7.5 mg which seems odd. I have one full 7.5 mg pen so thinking of 5 weeks of 6 mg.

OP posts:
LilyFeather · 04/01/2026 23:37

10mg give or take

I’ve maintained for a year now and take about 7.5 a week and hoping to bring that down over the next next few months

part week I inadvertently took 15mg. Just don’t ask. Suffice to say, I spent a long night on the toilet with terrible diarrhoea which was just a whole heap of misery tbh.

Charlenedickens · 05/01/2026 08:45

10mg, it was optimal for me, suppression was 24/7 , no ill effects, could still eat, got hungry, got full after a reasonable portion etc, so I never went higher.

I also didn’t mess about with quarter or eighth of a doses or whatever, a full dose is 5mg, and a half dose is the 2.5s. So I just moved up as they recommend to my optimal dose. Now on 5mg for maintenance.

AcidicTrifle · 05/01/2026 08:48

I went all the way up to 15mg without any issues. But I did that over 18 months, lingering for a few months at a time on 5, 7.5 and 10. By the time I got to 10, my body was used to it and the doses were less effective.

KitsyWitsy · 05/01/2026 09:01

I've been on this for about 15 months. I have injected up to 12.5 but couldn't cope with it and when I go up, I have to go up by .5mg at a time or it's too much to handle. I think I am just really sensitive to it.

Whereissummer24 · 06/01/2026 08:32

10 months in and on 12..5 - have never had any side effects. Lost 2 stone and still 1 to go. I’d move to 15 if it wasn’t so bloomin expensive! Dreading reducing back down when I hit goal in case it all piles back on. I have undiagnosed ( But I’m pretty certain of) ADHD and the effect on my daily life and mental health have been miraculous

Wallywobbles · 06/01/2026 08:56

I’ve been on 15 for 5 months maybe. Not losing anything at the moment.

Somethingsnapped · 06/01/2026 17:43

Were you still losing weight on the lesser doses before you moved up? Because if so, could you just stick around on the dose you liked? I've stayed on 2.5 mg for 5 months now and still losing at a rate I'm very happy with. I don't have appetite suppression anymore, but because it still seems to be working well on blood sugar dips and troughs, I can still manage my diet well. I do get very hungry before meals etc, but it just doesn't feel urgent like it used to! So I'm happy to stay here while it's working for me. I like the fact I don't really get suppression anymore, because I'm hoping it'll mean I can still cope when I come off, which I definitely plan to do. I've lost 36 lbs. I'd like to lose another stone, then come off altogether.

CloudyYellow · 06/01/2026 19:25

Hi I was still losing 1-2 lbs a week mostly. Some weeks stayed the same but thought going up a dose would help with weight loss. Unfortunately got side effects and less suppression as needed to eat a bit more to settle nausea. I am back to 6mg and feeling so much better...

OP posts:
ohlalalalaha · 06/01/2026 19:43

I’ve been on 7.5mg for the past 4 months but in the last month suddenly started to feel horribly nauseous all the time. I looked it up and it’s possible that because I’ve lost 3 stone, my smaller, less flabby body can no longer tolerate 7.5mg. I’ve dropped down to 5mg this week and I’m definitely experiencing more food noise but so far it’s manageable and I can swot the thoughts away relatively easily. It is strange to have them again though after 10 months of silence.

I’ll see the month out on 5mg but if my weight creeps back up, I’ll jump back up to 7.5mg again. For me, feeling sick is far better than the awfulness of gaining weight so it’s the lesser of two evils.

mullers1977 · 06/01/2026 19:55

JMSA · 04/01/2026 19:02

I’m on 15 but could easily manage a 3 course meal. I’ve never had total suppression.

I got up the 12.5 and felt like that x

Gettingbysomehow · 06/01/2026 19:57

10mgs is the highest I could tolerate. 12.5 was awful. I couldn't eat or drink anything without feeling my stomach was going to burst.