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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

November 2025 Mournjaro starters

1000 replies

Nearlyamumoftwo · 01/11/2025 15:05

I've just collected my first supply and wondered if anyone wanted to join in with the journey! I'm on 2.5 and I'm 14st1, goal weight is 12 stone as that is my pre baby weight and we'll see how I feel once I've reached it!

any tips on when to take it each week? I'm going to avoid alcohol and even though snacking is my weakness I think purchasing a supply is going to make me stop in a weird way. Any tips gratefully received and if anyone wants to join the journey for support and no judgment here's the place!

OP posts:
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Fifiellz · 12/12/2025 17:57

I only had this crushing tiredness twice on 2.5 and both times it was just in the evening after my first and second doses. It did settle after then so hopefully it will get better - I might even be coming down with something so will give it the benefit of the doubt for now. I was really happy with the way it was all going and have lost 18lbs in 6 weeks so I will be disappointed if this is ongoing as it’s really making me feel rubbish. But I’m glad I tried the bigger dose even if I do end up staying on 2.5.

TaffyTabby · 12/12/2025 18:26

@Fifiellz same I’ve had tiredness but only the day after the jab and it hasn’t lasted too long. It is horrible though, feels like the start of a nasty virus. And there’s plenty of those going around too.

18lb in six weeks is amazing!

Would any of you consider switching and trying wegovy instead? I went with MJ as it’s meant to be most effective but my friend started wegovy at the same time and she’s having no side effects and she’s lost the same amount as me.

NattyGoldNewt · 12/12/2025 19:55

Hi everyone,
I'm late in joining, but hope its OK to. I started on 7th November and just started my second pen. I decided on a 3.75mg dose for the 6th jab as I was nervous about a full step up to 5mg. So far, I've managed to lose just over 16lbs which is incredible. Amazing seeing everyone's progress so far. Well done to all. 🙂

Springbaby2023 · 12/12/2025 20:35

@PatheticDistraction what dose are you on? I felt like that just before I stepped up to 5mg. Also I think it’s ok to still have treats and bad days, for me part of the point of being on MJ is learning how to have these in moderation and not just let it start a weekend (or week) of binge eating.

@tobee I agree, the step up to 5mg has been fine for me, I massively overthought it. Yes I’ve had chronic tiredness but I had that at 2.5mg too and it’s lessened off so I’m hoping it’s just part of changing dose. It didn’t stop me exercising but that may be because I’ve already got a good exercise routine on the go.

My biggest issue at the moment is while I am definitely eating less food, I’ve not gone off cappuccinos / flat whites or wine, so I’m still having a lot of empty calories. However so far this week I’ve lost 3lb, putting me on 10lb down in just over a month which I’m chuffed with. I reckon January will be easier without all the festive temptations!!

Springbaby2023 · 12/12/2025 20:35

@NattyGoldNewt thats incredible, well done !

PatheticDistraction · 12/12/2025 20:43

@Springbaby2023I did my 2nd dose of 5mg today & I'm happy to report that the suppression appears to be back!

I skipped breakfast, had a turkey bagel for lunch & wasn't hungry at dinner, but managed some pork & broccoli.

12lbs down now since starting on 7th November, feeling excited again!

NattyGoldNewt · 12/12/2025 20:45

@Springbaby2023 Thanks, its hard to believenit myselr. The rate has slowed and appetite has been increasing at 2.5mg. I was boosted by cutting out takeaways and fizzy drinks which are definitely my weakness.

NattyGoldNewt · 12/12/2025 20:50

@PatheticDistraction that's amazing progress. Has 5mg felt ok? We started the same time it seems. I was too anxious about 5mg today so opted for 3.75. Hoping it doesn't bring back the exhaustion I had a couple of weeks ago.

Has anyone else noticed an improvement in sleep? I seem (according to fitbit at least) be sleeping better with less waking.

Also wondering if anyone else has a weird ear sensation? As though being underwater or it needing to pop? It is intermittent and quite annoying but I've not had it before.

TaffyTabby · 12/12/2025 21:23

Hello and welcome @NattyGoldNewt
I think my sleep is worse sadly, but my kids disrupt my sleep anyway! And I haven’t had any weird ear sensation.

Springbaby2023 · 12/12/2025 21:35

@PatheticDistraction Good to hear! I’m taking my second dose of 5mg tomorrow, bringing it forward two days early as want to ideally take it the Friday before Christmas so I don’t have too much suppression or side effects for Christmas itself!

Wethers121 · 12/12/2025 22:43

JustBeach · 12/12/2025 15:01

I took the extra dose in my 2.5 pen by forcing it round last week. I did also take it a day early. 2.5 had been wearing off during week 4, but this week I’ve had really strong suppression like during week 1! I’ve been struggling to eat and my weight has started dropping again after not losing for a week. I’ve got my 5mg pen ready to start on Monday but I’m scared to increase now! I think I had a bit more than 2.5, as there was some coming out after and then the day early. I’m considering staying on 2.5. I’ve only got another stone to go and am just back in a healthy weight - so I don’t feel I need a big rush and make myself ill. Christmas complicates, because I don’t want to feel poorly when we have visitors!

I’m sticking to 2.5mg too. I had really good suppression week 4 so it swung it for me. Similar to you, I only have just over a stone to go so I’m happy to take it steady to get there.

tobee · 12/12/2025 23:38

My suppression/feeling of satiety on 5mg is not really much different to 2.5mg. Like I should imagine most of us, I was hoping to be one of those able to go through the entire process on 2.5 or 5; the cheaper doses, but I'm already wondering if my next pen will need to be 7mg ☹️. Oh well!

It was the last session before Christmas of my "hobby group" this afternoon. And one of our number kindly brought in some champagne. It was my first bit of alcohol since starting mj. I only had half a glass as I was driving. Interestingly it didn't seem to have any weird effects. It tasted lovely but didn't make me feel I've been missing out. That's one of the better things for me - being able to enjoy food and drink but it being fine to just have a sensible amount.

RoundandSad · 12/12/2025 23:54

@tobee sorry I can't keep track
You are one of the posters who's losing weight aren't you?

Well, it seems like basically everybody is losing weight faster than I am everyone who started this november anyway

So if you are losing weight and losing quite a bit, then you could just stay on the current dose

tobee · 13/12/2025 00:12

Since November 9th, my start date, I've lost 7.5 lbs @RoundandSad, so definitely not one of the fastest losers.

I was maybe being a bit pessimistic in my previous post. My criteria for it working for me, the base level, is to lose weight by eating fewer calories but it not being a massive psychological struggle, where I'm desperate to give up and constantly missing takeaways, biscuits, crisps etc. The weight loss can be the same on a weekly basis as previously. That's the absolute least I can hope for I think.

I'm really keen for this to work. Previously I've only been able to lose weight to get to about 27 bmi; or to dream of that.

TheP1per · 13/12/2025 07:44

I’ve been a bit hungrier the middle and latter part of this week. Have lost 1kg but I need to start a new pen. I’d like to try 3.75mg and I have a 2.5mg and 5mg pen. My mathematically challenged mind says use both pens to achieve this but I’d rather not have 2 pens going. How would you all do it in this instance? I don’t really want to waste any doses or part doses.

diggitydoo · 13/12/2025 08:35

i did the golden dose out of my 2.5 pen on Thursday. I got a does of about 3 out of it. So not a massive increase! But I feel abiT scunnered by it. Nausea and constipation. And also totally depressed. Been utterly flat and keep having crying jags. Does anyone feel like that?

SexyFrenchDepression · 13/12/2025 09:09

TheP1per · 13/12/2025 07:44

I’ve been a bit hungrier the middle and latter part of this week. Have lost 1kg but I need to start a new pen. I’d like to try 3.75mg and I have a 2.5mg and 5mg pen. My mathematically challenged mind says use both pens to achieve this but I’d rather not have 2 pens going. How would you all do it in this instance? I don’t really want to waste any doses or part doses.

3.75mg is 45 clicks of the 5mg pen rather than 60. For 2.5mg pen it would be 90 clicks for that dose, you'd need a syringe for the 3rd dose probably. .

BoxingHares22 · 13/12/2025 09:19

I am starting today. A bit anxious about doing it right as the instructions are a bit off putting. I don’t have a sharps bin so how do I dispose of the needles? Do I do it before or after meals?
My blood sugar has crept back into diabetic levels and I am wondering if those in the same situation avoid carbs whilst on MJ?
Any advice on the best time to do it?

TaffyTabby · 13/12/2025 09:59

@BoxingHares22 you could check for a YouTube video or if your provider has any video guides? I’m better at following something visual than instructions. Your provider should have sent you a sharps bin. I would put your used needles in a plastic box until you can get a proper sharps bin.
I’m not sure about your other question, sorry.

@diggitydoo I think I have also been more flat in mood since starting. Not sure if it’s cause I’m missing the dopamine hit of food. Also feel like I’m less interesting in doing other things I’d usually enjoy eg watching junk tv.

NattyGoldNewt · 13/12/2025 10:17

TheP1per · 13/12/2025 07:44

I’ve been a bit hungrier the middle and latter part of this week. Have lost 1kg but I need to start a new pen. I’d like to try 3.75mg and I have a 2.5mg and 5mg pen. My mathematically challenged mind says use both pens to achieve this but I’d rather not have 2 pens going. How would you all do it in this instance? I don’t really want to waste any doses or part doses.

I did 45 clicks of a 5mg pen last night. Feel OK so far. 60 clicks would have been the full 5mg dose. I was feeling hungrier the last two weeks and craving sweet things so decided to go up after extracting the fifth dose from the 2.5mg last week.

NattyGoldNewt · 13/12/2025 10:20

BoxingHares22 · 13/12/2025 09:19

I am starting today. A bit anxious about doing it right as the instructions are a bit off putting. I don’t have a sharps bin so how do I dispose of the needles? Do I do it before or after meals?
My blood sugar has crept back into diabetic levels and I am wondering if those in the same situation avoid carbs whilst on MJ?
Any advice on the best time to do it?

I got a sharps bin sent from my provider. I think you can order them from various pharmacies online. It was only a smallish one that got sent but the needles are small so I hope it should be sufficient.

I don't know about best time but I tend to take mine in the evening and have a light dinner after. The jab hasn't seemed to kick in till the next day for me typically.

RoundandSad · 13/12/2025 10:21

@BoxingHares22 you must must must get a sharp bin. It's really irresponsible to dispose of it any other way. That sharps bin must be disposed of in medical waste. You will find a pharmacy or someone who does it locally.

Rushing about today, but will reply to others later because it people are getting the side effects I have - last night I woke up with a sort of band of indigestion pain as well that's new on top of all the other stuff 😭

NattyGoldNewt · 13/12/2025 10:22

TaffyTabby · 12/12/2025 21:23

Hello and welcome @NattyGoldNewt
I think my sleep is worse sadly, but my kids disrupt my sleep anyway! And I haven’t had any weird ear sensation.

Thanks, its good to be sharing the journey and tips with others!

Sorry to hear your sleep is worse. I may just have had a lucky week of sleep or more likely work has just totally wiped me out!

CallMeStella · 13/12/2025 10:41

putthehamsterbackinitscage · 04/12/2025 11:47

Bolt are fairly easy too 2 photos, I’d and previous prescription label.

I’ve had an email from them today upping the referral discount and credit, so if anyone wants a code for Bolt, let me know.

How much discount does bolt give for your referral code? I need to reorder the 7.5mg and debating whether to stick with Bolt or go for one of the new customer codes

SexyFrenchDepression · 13/12/2025 10:57

CallMeStella · 13/12/2025 10:41

How much discount does bolt give for your referral code? I need to reorder the 7.5mg and debating whether to stick with Bolt or go for one of the new customer codes

I'm not sure re Bolt but you cant use codes as a current customer but can refer others and get money off your next order. I have codes for Pharmacy 2u and Lotus.

I was going to stick with one provider but got too tempted by saving some money, so have used 2 other providers since.

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