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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

You've reached your goal weight - come chat about maintenance, not regaining, going cold turkey or titrating down

996 replies

MargoLivebetter · 15/01/2025 09:26

Would people who've hit their target weight be interested in a general thread on how they are getting on? You might be titrating your WLI down, you might be going cold turkey, you might be on a maintenance programme or you might have gone back on.

I used MJ for 5 months and I've hit my goal and I'm muddling through with my own version of "maintenance". I'm doing a 1.25 dose weekly to use up what I've got left and cut down gradually, so I don't lose all the benefits of MJ immediately. I was a complete lightweight and did the whole 5 months on just 2.5, as I had savage suppression and loss of appetite. So, I'm just halving my dosage.

I'd be interested to hear how others are getting on, given it all feels a bit new and the long-term aspects of weight maintenance are not yet much talked about.

OP posts:
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Histoscientist · 13/08/2025 18:44

The lack of interest is due to dopamine pathway disruption. I was taking L tyrosine from may to mid june which resolved this and brought me back to a much happier, outgoing and getting on with all kinds of DIY jobs kind of person, but then I started 15mg and since I've been on it I gag at anything and struggle to eat, let alone swallow vitamins so I stopped taking it. Back to exhaustion feeling low, no interest, 'please leave me alone' phase that ive had for 8 months of the start of Mounjaro! Luckily I've taken my last week of 15mg and im about to go down to 12.5mg, the whole time has been a struggle to eat and nausea, managed 715 cals on Sunday, around 800-900 last 2 days and that's forcing it in. I was stupid enough to do the 0.7ml of bonus dose friday, more fool me, so this week has been the worst. Only myself to blame! Still very full now and ive barely eaten, so I'll delay my next dose!
I'm at bmi 24.2 now anyway lost 1.7lbs last week because I could barely eat, this is a huge amount when I'm only 9st 11lbs, so im going to come down and taper off, reached my limit! The only concern is I work long days and drive 82 miles a day, leave house 6.30-7.10pm and return 5.30-7pm depending on shift and traffic so I don't know how ill fit in exercise when I come off it to tone up/burn cals. I've lost 3st 4lbs without exercise so far.

MontyJinks · 13/08/2025 19:12

Hello, can I join in please? I've finally got to goal 🙌🎉

Started at: 13st 6lbs, BMI 36.7
Now: 8st 9lbs, BMI 23.6 (I'm a short person!)

I've been overweight since childhood, so have no previous experience of maintenance, it all seems a bit of a minefield. Not sure which approach to take yet, but wanted to say thank you all for your lovely and varied shared experiences on here. It seems like it's a bit of pick an approach and 'try it and see' so I'll start to have a think.

Mounjaro is absolutely life transforming and I am so grateful for it 😍

gimmemounjaro · 13/08/2025 19:14

If you don’t mind @Histoscientist, could you share which L tyrosine you were taking? I feel like that could make a big difference to me.

Histoscientist · 13/08/2025 19:27

gimmemounjaro · 13/08/2025 19:14

If you don’t mind @Histoscientist, could you share which L tyrosine you were taking? I feel like that could make a big difference to me.

It's from amazon Multivita 500mg, they have many brands though and I'm sure they would all work. Look up the reviews as that really sold it for me when I was looking into it.

20bloodypounds · 13/08/2025 19:32

@MontyJinks I thinks it's more - look at the options and choose one that fits your body / psyche best. I never went very high with my doses so titrating down is only a couple of months and I'm back on 2.5mg now. Currently stretching out the injections to 9 or 10 days (supported by my prescriber). I'm interested to see how hunger feels and how I react to it, and the impact on my weight, so I'm interested in doing one month on,one month off.

I find maintenance is psychologically a bit flat. There are none of the highs of losing another pound or seeing my weight loss graph progress. I feel a bit of anxiety when I'm up by a kg, and then relief when I'm back down. I'm a daiy weigher and maybe Ineed to move away from that...

MontyJinks · 13/08/2025 21:13

Thanks @20bloodypounds I only made it to 7.5mg, so planning to titrate down to 5mg for the next pen as a first step.

Itscoldouthere · 14/08/2025 07:24

I’ve been lurking but feel I should now join you all 👋
‘Ive been taking Mounjaro since July 2024, reached my target in about March so have been coming down since then, 10mg was my highest and I’ve been on 5mg for a couple of months now.
I was planning on moving to 2.5mg but I took 5mg again yesterday as I’ve found myself slightly overeating/snacking this week, I was away at the weekend I drank more alcohol that I had in a while and have been feeling like having a glass at home this week which is something I had stopped.
Weight wise I have continued to loose a bit even though I’m eating more, I don’t want to loose now and I’m working out with weights at home.
I would say my mood is very flat has been for quite some time and that’s the only thing that makes me think about coming off, I had thought I’d continue taking a small dose, maybe a half dose from 2.5mg for a year or so, just to make sure I can keep at this weight, but the flat feeling is starting to get to me a bit so I may change my plans.

gimmemounjaro · 14/08/2025 07:32

Thank you @Histoscientist I have ordered some.

Not sure if this is common knowledge but a couple of options if people want to try coming off MJ for a bit with the option to go back on - Simple Online Pharmacy allow you to do this with a 3 month window for restarting. After that you would need to meet the original criteria of BMI 30 / 27 etc. Swift Doctor offer the same but with a 12 month window. You can transfer to Swift at any BMI (healthy or above) and need to have had at least one pen from them before stopping.

MargoLivebetter · 14/08/2025 08:46

Welcome @MontyJinks and well done for having lost the weight. WLI are incredible aren't they. I've battled with my weight since my early teens too and MJ has definitely changed my life. Keep us posted with how you get on.

hello @Itscoldouthere and welcome too. It is a tricky balance trying to work out how best to come off. Do you know what is niggling away in your brain that makes you want to snack - boredom, habit, anger, sadness etc etc. Or are you actually hungry? For me it helped to get to the bottom of that, as then it meant I could work out how best not to let my feet automatically pitter patter their way to the kitchen so that before I knew it I had a snack in my mouth!

OP posts:
Sadteacher · 14/08/2025 09:11

Well done and welcome to the new maintainers!

@jellyfishperiwinkle good luck with 15. I had no side effects apart from tiredness until half way through my 12.5 pen then I had a week where I couldn’t get off the toilet! I thought I’d got away with it until then!

My scales are finally moving down again. I’ve 2 doses left in what I hope is my last ever pen. I am 10.7 today and my max happy weight is 10.4.
Again, I wish I’d got down to 10 before stopping the pens to give a bit of leeway. Two holidays and half a stone was back on again.

I have also been exercising 5 x a week to support long term maintenance after years of barely any exercise.

I also meant to mention how I think my scraggy neck is looking better. I have slapped on moisturiser twice a day and suddenly it doesn’t look as bad. My skin is catching up with my weight loss ( which was always slow and steady, max 6lbs in a month, even my first month which probably helps with skin sagginess a bit) I am bmi 26 which probably also helps with padding out the skin a bit, I am in my fifties.

Fromthesidelines · 14/08/2025 16:27

Afternoon all. Can I join you?

Started in May last year and reached goal a few weeks ago and been bouncing around since. My BMI is only just in the healthy range and I have a lot of flabby bits still, but also a lot of wrinkly bits. So my focus now is on exercise and fitness and hoping for a bit of body recomposition. I'm in my sixties so that may not be realistic.
I went up to 12.5 but am now on 7.5. My plan had been to titrate down very slowly, possibly staying on until next summer, but the imminent price rises have made that plan unaffordable. So I have ordered 3 pens and will be off mj after that. I'm really hoping to be able to maintain but so scared of putting it all back on.

GLP1Girl · 14/08/2025 18:56

tinyemmy · 13/08/2025 18:35

How interesting, unrelated to the conversation but I've been on desogestrel 20+ years due to migraines (I'm also on progesterone pill, oestrogen gel and oestrogen pessary) and I've struggled with vaginal atrophy despite the pessaries. I don't think I can take the mini pill but I wonder if I need more oestrogen. My libido is non existent, this was pre-mj. I wondered if it was because I was unhappy with my body, but I've lost the weight and still have no interest, plus not sure it works anymore 😱

You might need more oestrogen for the VA. And testosterone for libido.

Your GP can do the blood tests - (Oestrodiol levels,
Free androgen index, Serum testosterone all need to be done) then get a referral to a specialist clinic if needed (or book privately) as testosterone is out of license for GPs to prescribe.

Medsweightgain · 14/08/2025 21:52

Another lurker, unlurking. Thanks to all who have posted here and to @MargoLivebetter for starting the thread - reading back through everything has been so helpful.
I feel guilty for saying that I haven’t had lifelong or long-term weight issues - my “issues” (hate that word) are chronic migraine and treatment-resistant major depressive disorder. As you can imagine, both have required multiple medications/treatments, and in H2’24 my weight was increasing at a rate of ~1kg per week. Despite me telling this to all the health “care” professionals, no one cared.
In January, I volunteered for the NHS Our Future Health study, and weighed in at 80kg, height 162cm, thus a BMI of 30 - and clinically obese.
I also have PCOS, and high LDL cholesterol (as long as they have been doing tests - referral to a lipid clinic made in July’24 has just sent appt for end of Sept 🤞🏻).
I didn’t think it was possible to feel shittier about myself than I already did. The nature of migraine/depression for me has major components of self-blame, low self-esteem etc; and practically, fatigue, isolation, lack of self-care, inactivity etc.
I didn’t/don’t have the funds for MJ, and shouldn’t have, but I couldn’t cope with another diagnosis/label (clinical obesity) and the consequences, so purchased from ever dwindling (on sick pay) savings.
I’m now in the middle of the healthy BMI range. My last pen was a 12.5mg, which in theory I didn’t need to use but am tapering on it by counting clicks - not with the need to loose more weight, but to come of MJ slowly, and taper rather than full on cold turkey - 48,48,36,36,24,24,12,12 is the plan, and I’ll figure the calculations in mls for the “golden dose” when the get there. Yes, this is way beyond the 4wks recommended shelf life for an open pen, but I keep it in the fridge, my injection practices are as careful and sterile as I can be, and I have a science research background so am happy with this level of “risk” for myself.
Of course, being back to a normal BMI hasn’t fixed the other shite……but it is one less thing to worry about. I am extremely fatigued, and it’s impossible to tell if that’s from any of my diagnoses, or side effects of those medications, or from MJ. It was in all likelihood the recent posts about people feeling like they have no energy on MJ that ultimately prompted me to share. I’m hoping that as I taper down, I might see an improvement in energy.
I was definitely eating more take out and ready meals prior to starting MJ - no interest or energy to cook - and have found since starting less interest in eating at all (realistically, I was likely undereating, even with minimal daily activity). However, I’ve made the effort to substitute the take out and ready meals with fast, protein rich meals, and batch cooking things like bolognese (half beef, half lentils) on the days I really have energy and freezing.
I can’t say I’ve had any major side effects aside from constipation, and heart burn…managed with kiwi fruits and gaviscon (not at same time! 😂), and really focusing on water intake. Summer food is definitely easier for me - a plate of Parma ham, tomatoes and mozzarella takes seconds to make.
While I’m back at healthy BMI, I’m totally unfit, and feel soft and wobbly. I didn’t exercise or lift weights - I know I should have, but I don’t have the energy/stamina….i need a nap after doing anything. That’s the next thing to address while tapering.
Anyhow, the point of this monologue is to share a slightly different story from what I’ve read here so far, and my tapering plan.
And most importantly, to thank you all, wish you luck on your maintenance/post MJ journeys, (hoping today’s news about the Sept 1st price increase isn’t causing awful anxiety), and again to acknowledge @MargoLivebetter for setting up such a helpful thread.
Sincere thanks.

MargoLivebetter · 14/08/2025 22:18

Crikey @Medsweightgainthat is quite the journey you have had along with so much else to deal with. Well done for taking control yourself of the weightloss and for persevering too. Like you say at least you have one less thing to worry about. Good luck with the tapering down. Let us know how you go. I hope that some of the tiredness might lift as you taper down. 🤞

OP posts:
MargoLivebetter · 15/08/2025 08:59

Welcome @Fromthesidelines and congratulations on your loss. I'm glad you were able to get your order for supplies in. The price rise business is really bad news. I didn't need another reason to dislike Trump (apologies to any posters who like him) but he's just given me another!!!! Grrrr!

OP posts:
Fromthesidelines · 15/08/2025 11:28

Thanks @MargoLivebetter
I had a plan to titrate down slowly and maybe see if I could maintain on 2.5 for a while before coming off completely in the hope that there is something in set point theory. I'm now going more quickly down than I intended but that may be good as I have wondered whether mj was too much of a crutch and if my dependence on it was as much psychological as physiological. I will soon find out!

blessingindisguise22 · 15/08/2025 20:41

What a clusterfuck of a few days! I refuse to buy from companies that treat their customers badly. Eli Lily has handled this awfully. It's made it easy for me to decide not to use mounjaro for long term maintenance.

jellyfishperiwinkle · 15/08/2025 20:45

Why don't they just tell Trump to fuck off? How does he just have a brainfart one day and Lilly say "Oh yes, sir! Right away, sir."

20bloodypounds · 15/08/2025 22:39

I think most of us on this thread are so fortunate that we are at or near the end or our MJ journey, and that we have a variety of options for managing the cost.

I'm currently back to 2.5mg - stretching out the doses to every 9 or 10 days, and have a couple of 2.5mg pens on order (August prices). Then I was planning to do one month on,one month off. That's going to be a little more expensive now, but managable. Lucky me.

I feel so sore for people who have recently started this journey. I would never have started, nor would I have managed finacially if MJ had been this price - with increasing prices as the doses go up.

blessingindisguise22 · 16/08/2025 08:09

@20bloodypounds We really are so lucky. I feel really sorry for those with a lot of the way to go.

gimmemounjaro · 16/08/2025 08:44

I saw someone making the point that anyone can go to the GP and be prescribed meds for high blood pressure, high cholesterol, type 2 diabetes, joint pain / arthritis, any number of inflammatory conditions, IBS, plantar fasciitis, depression etc etc etc, no questions asked. Many people are on a combination of several of these medications. But ask for one single treatment that can improve all of these problems massively - it’s almost always a hard no from the NHS and now getting harder to manage privately. Just so stupid and frustrating.

I suppose when patents expire and GLP1s are cheap, GPs will be prescribing them left right and centre, just like statins today.

Pinkyp22 · 16/08/2025 08:45

Hello

Can I join this group, looking for general advise on maintaining weight loss after Mounjaro.
I started Mounjaro in July 24 at 106kg
Im currently filtering down doses having reached 76kg. I wanted to get to 74kg but life has been very stressful recently ( my mum passed away and my sons father has terminal cancer) so I have been dancing with those Last lbs for several months.
I have a small stock in the fridge which will last me 6-8 weeks depending how I chose to dose. I will probably jab every 10 - 14 days probably at around 5mg for a while.

It's a bit of daunting thought. I do have a little more food noise than I have before, but thankfully I am able to deal with that.
I do need to find an exercise to stick to, but I really don't enjoy exercise 🙄

blessingindisguise22 · 16/08/2025 08:55

As much as I agree about glp1s benefits, Glp1 also needs consultants and research to show these other benefits. When that happens some GPs and other prescribes will be more willing to prescribe off licence. Of course once there's enough evidence for NICE to recommend the treatment it'll be even easier.
I can't blame GPs for not wanting to prescribe something that only has anecdotal evidence.

gimmemounjaro · 16/08/2025 09:02

I mean, nobody is asking their GP to generalise their experience to population level. Maybe anecdotal evidence is just fine when you have a patient reporting benefits, many of which are also scientifically measurable. There’s really no need imo for a GP to wait for a study to tell them that GLP1s might reduce blood pressure when they have a patient sitting in front of them whose blood pressure has fallen since being on GLP1s.

blessingindisguise22 · 16/08/2025 09:03

@gimmemounjaro Yes good point well made! Thank you 😁 I'd only been thinking about patients not on Mounjaro already.