I get it completely.
We moved out of London to Hampshire and knew we had made a mistake, I couldn't pinpoint it but we simply weren't happy. I could have continued it but my husband was miserable.
We managed 4/5 years.
It's a brave thing to move again but I am SO happy we did it. We moved to Woodbridge, Suffolk and have never looked back. For me it came down to the people. Now I look back, I recognise that althought we made some magic friends, the commuter belt simply wasn't us.
We needed to be around folk that weren't quite so organised! We are both creatives and work in that sector - we needed to be around people that sort of did their own thing, I realise that you have a great budget but for us, creativity came from living somewhere that was much more mixed.
The crucial thing we did, was to rent out our house, and rented a lovely place in Suffolk for about 3 years, minimising the risk if we weren't happy so that we could find the place that we were.
Our story is a happy one, I recognise the strain we were under during that period of decision making.
My advice is to do the same, think about renting your house out and renting somewhere else. Paint your walls white, know that there are going to be come costs, but also the benefit of someone else having to fix your boiler if it goes wrong.
Renting gave us options and more importantly space to clear our heads.
As to where, you have options, likely too many.
My advice would be to think about where your mates are. You mention the family pull isn't huge, so think about areas that you like near to friends that inspire you.
Freelancing is great for now, perhaps you may even have your own business in time (you sound like a talented lady) so I'd work to continue your level of comfort, perhaps even come down a level or two in order to save some spends for lovely holidays and family time when you get them.
One last moot, renting may save you from Brexit uncertainty and all the other rubbish that it's bringing.
Best of luck and if you want to dm me, you are most welcome.