Immune/ NK cells - Pred threat 27

[LaurenAB94]

@Bambii @Daffodil21 @Eeviee @Everhopeful35 @farfromperfect82 @Eeviee @Everhopeful35 @Hazlet2 @farfromperfect82 @HoldingOn2Hope @Jellystar23 @KtAgs @Lalaifa @LookingforAnswers86 @Marabouchoc @LRL12 @MrsMargot @Naticle @NessyT91 @NessyT91 @NICK7nick7 @rainwillmaketheflowersgrow @Rebecca9876 @Sophfr17 @Tinpo @VenusStarr @Wheresmyrainbow @Whyisthistakingsolong

@VenusStarr thank you. We left at 6.30am as appointment at 11am. Got a couple of books with me 😄. Does it take about 1.5 hours to administer? Hope you are well xxx

Ah, hope the traffic is OK for you @Rainbowdreams1983 it's normally about an hour for me. It goes fast though! Let me know how you get on 🙂 xx

@VenusStarr traffic fine. Just waiting to have them now. Oh good glad it goes by fast. I will probably fall asleep lol! 🤣 xx

I always have my feet up @Rainbowdreams1983! 😂 Get comfy xx

@VenusStarr I had my feet up 😁
Not long got home. Soooo tired as had about 4hours sleep last night, been up for over 12 hours so tea, shower, pjs and bed. So rock and roll lol! Hope you've had a nice day xx

Hey everyone, just realised I’d missed lots of messages of support so belated thanks! My head has been all over the place with the stress of it all.

Just been for my NK Cell biopsy and well ouch! Glad it’s over. My consultant also upped my dose of letrozole to 5mg and said I can start that while we wait for IVF. I told him I’m not starting IVF until I’ve left my job and I’m hoping that will be soon. I know I’m going to need a bit of time to relax and feel strong enough to try so the letrozole will make me feel a bit better that I’m not ‘wasting’ months at least!

@Tunby I just read your post about the hydroxy. I can’t believe they told you it was dangerous. I spoke to the nurse tonight about it and she said it’s a very safe drug and probably the best thing to be on with Covid around! It’s so odd how medical opinions can vary so much.

@Rainbowdreams1983 glad you’ve had your intralipids!

I’m wondering what treatment I’ll end up on but guess I need my vision results first and those will take a few weeks.

@VenusStarr how are you doing?

Hope everyone else is well! X

@Badlydrawngirly thats great news about your biopsy. Was it really painful? I'm glad you have a plan in place in preparation for when you are ready to try again. How are things with work now?

Just waiting for ovulation now, using the daily clearblue ovulation tests. I must have spent hundreds on these during the past 3.5 years 🙈

I hope everyone has a fab Bank Holiday.

Xx

I'm glad you had your biopsy @Badlydrawngirly hopefully you'll get some answers. I agree, it's not pleasant!

🤞 For ovulation soon @Rainbowdreams1983

I'm doing OK, starting to get a bit anxious now, I'm 7dp5dt and up to yesterday was quite hopeful but woke up today feeling a bit of fear. Going to try to focus on the things I can control as worrying is going to make me feel bad.

Hope everyone has a good Bank Holiday and hope we get some sunshine ☀ xx

@VenusStarr when can you test? Absolutely everything crossed for you x

I've got a beta blood test on Monday @Daffodil21 but my official test day is Wednesday. Thank you, trying to hold onto my hope 🙏 xx

@VenusStarr ah how nerve wracking! I'll be thinking of you! 🤞 x

@VenusStarr I will be thinking of you on Monday...not long to go 🤞🤞🤞. The fear when it comes to testing is horrid isn't it! How are you doing today? I hope you are able to enjoy this gorgeous weather ❤

I'm now on high fertility on my clearblue monitor which is fab as it means I will ovulate at the right time in my cycle this month which is hopefully a good thing. Currently on day 12 so possibly in the next few few days...

Xxx

Hi guys wondering u can help! I used to be under mr shehata a long time ago and had my son after 6mc.
I’m now trying for a sibling. Had ivf transfer postive a few days ago, stronger line today. But started bleeding bright red today :(
I’m 4 weeks pregnant today . I feel. Like my symptoms are gone.
Do u know what mr shetata advises acutely? Bed rest? More Progesterone etc? Stop clexane and asprin? My ivf clinic are not great with mc but wondering I can advise them what to tell me to do!

Is there anyway this may work out :( I’m bleeding bright red

I didn't even make it to test day, bleeding started yesterday at 7dp5dt and pretty sure it's af today. I'm devastated. Been advised to stop the aspirin and clexane and see what my blood test says tomorrow but I have no hope left. We've both been crying most of the morning.
Thanks for the well wishes @Daffodil21 @Rainbowdreams1983 @Badlydrawngirly xx

@VenusStarr I'm so sorry, I'm absolutely devastated for you. Is it a proper bleed or brown? I had brown from 6-10dpo for this pregnancy. Is there any chance at all it could be implantation bleeding?

Hi All,

I’ve been following several of these ivf threads for a while it’s been helping to keep me sane during ivf. Ttc for approx 18 cycles over 3 years (OH works away 50% of time). 21 year M.E. Warrior.

5dp5dt FET and had a bit of a wobble this morning. Took a bit of a risk with this transfer after finding out have high TPO at start of Cycle - added in steroids this time around but decided on the back of this result that I would like my TSH tested for piece of mind. Came back as 3.7 so had to make a decision as to whether we wanted to go ahead within 24hours or cancel and start on thyroxine for 4-6 weeks (general recommendation for pregnancy is TSH 2 or below). Couldn't face the thought of cancelling cycle especially when I’m not convinced embryo is viable and could only find one study where TSH of 2 or below made a difference but this was in women who started out of normal TSH range i.e they were above 4.5 anyway. In terms of embryo maybe not being viable unfortunately OH went back to smoking before EC due to huge levels of stress at work which was less than ideal. It’s our last embryo of this round so it’s all a bit of a gamble.

Didn’t get hopes up at all before the transfer but they did say embryo was expanding (don’t they all after defrosting??) and they seemed very encouraged by that at transfer. Started to think that maybe it could have worked this time round (was convinced 3dpt last time it hadn’t and it hadn’t) but now getting my usual PMS mood swings today so been on a bit of a downer. On top of that am really struggling with steroid effects only managed 5 hours sleep last night on the back of two previous nights of poor sleep plus ravenous hunger, constant peeing, feeling hot etc...despite being on a low dose. So all in all felt pretty rubbish this morning! Thought I would post on here and see if anyone else is on steroids and/or on their 2ww just looking for some ivf buddies and somewhere to rant.

Thanks if you bothered to read all this!

No, it's definitely red, af-like @Daffodil21, sadly. My ivf clinic uses utrogestan so I thought it could've been an irritated cervix but I've swapped to cyclogest back door and the bleeding got heavier. Really upset that I'm bleeding on progesterone x

@VenusStarr I'm so sorry. I honestly can't imagine how gutted you must be feeling ❤️

I had a bleed while on cyclogest and my consultant said he thought my bleeding was because of the cyclogest. I used it in the front door though.

Thinking of you both! X

@InvisibleDreamer I’m sorry you have had such a long and tedious journey. I was wondering if you were taking the steroids in the evening and maybe try changing to the mornings. Tbh re thyroid, I have been ttc for nearly 3 years and have had 5 miscarriages and two failed ivfs whilst being on thyroxine and my levels controlled. I had two miscarriages before and was convinced it was my thyroid but having it regulated hasn’t solved my problem so maybe it has little effect on the outcome anyways? I hope it works for you... ivf is incredibly hard and sometimes the worst embryos manage to pull through. I think it’s all a miracle for it to work but I am doubtful now it will work for us. Both rounds of ivf for us were done with euploid embryos and they didn’t take and my one miscarriage was a normal embryo and the next one I have a meeting for a consultant on Friday this week to discuss as I’m sure it’s normal as well so you never know what you think isn’t good quality may be a fighter?

@VennusStar I am so sorry to hear you are bleeding. I use utrogestan as well instead of cyclogest and like I said above I had two failed IVF transfers. I have one last embryo left and will do an ERA test this month and then the transfer the month after and Ican completely understand how terrible it is to see a negative result. I was convinced going into ivf that it was going to work after all we got pregnant but it didn’t stay but now I can’t even conceive on ivf. I must admit that the medication you are taking and then going cold turkey on made my emotions even bigger and harder to handle. Did they monitor your progesterone during this cycle? The only thing I have found “wrong” with me that I believe that could affect implantation hugely is my vaginal microbiome was completely out of whack. Nothing I say will make your feelings any less or easier and I can only wish you the very biggest best of luck that bleeding is just a thing and it has worked. I know a friend who bled most of the first trimester with ivf and still delivered a baby in the end of that cycle. I’m really sorry...

Thank you @Unicorn9 ❤️ they checked my progesterone 2 days after transfer and it was 56, so they were happy with that. I did feel like I was better on utrogestan than cyclogest. But I literally woke up on Saturday and I knew it was over, I felt really connected before that.

I've been awake since 2am, so got up and watched a film. Dh has just left for work and I'm a mess, just suddenly really scared.

I'm going to make a list of questions to ask before we think of doing a FET. That's interesting about the vaginal microbiome - how did you get that tested, was it via your clinic? I'm really struggling with it all and like you say the meds and hormones dropping isn't helping. I've been thrown back into the horrible shock stage of grief. I'm not sure how much I can take.

I'll let you know how I get on later, but I'm not expecting any miracles. Sending love to you xx

@VenusStarr Hey at this stage I think your feelings are completely understandable. The only advice I can give is to try do something different for the next transfer if you can so you at least feel as if you change something up a bit. It is so hard because looking on the internet it looks like everyone just falls pregnant on ivf and it’s not true. Based on the stats the majority don’t unless they do lots of cycles so there is nothing “wrong” with you, maybe your body just needs a couple of go’s to get used to this unusual way of getting pregnant but try give yourself some time to grieve.

My doctor told me to do this test...
invivohealthcare.com/products/diagnostics/vaginal-ecologix/

I have no idea if it will make any difference what so ever mind but there was a very tiny study on it and it greatly affected implantation.... it wasn’t the most expensive test to do and the treatment was £18 of antibiotics so I didn’t think it was a bad option to try and we were reaching for some answers on something.

Try look after yourself, be kind to yourself and your body.... u will be ok even though you don’t feel it.... big hugs.

Hey @VenusStarr - have just seen the messages and I'm so, so sorry. I'm sure there's absolutely nothing that I can say to make you feel better but just know that everyone here will support you and please do continue to share your emotions. Sending lots and lots of virtual hugs. It can be impossible to feel hope at a time like this, but try not to lose it. Hopefully Dr S & the team are being supportive? ❤️❤️❤️ Do reach out any time if you just want to have a rant xx

@Badlydrawngirly hope the ttc is going well. I'm heading down for the second round of ovulation intralipids on Thursday.

Decided I'm just going to roll with it & try as best I can to enjoy the life we have without a child for the time being - like all the things we can do at the drop of a hat, especially now things are opening up again!! Trying to make the ttc as fun as possible haha.

Also, he proposed on my birthday! So I'm pretty much on cloud 9 with that!!! Can't stop looking at the ring 😊

Hope everyone is doing ok and enjoying the sunshine!! What a lovely change!! ☀️☀️☀️

Thank you @Tumby ❤️ I haven't contacted Dr S yet, I know we'll need to book a review with him before we can think of ttc or doing another transfer. I run out of hydroxy soon as well. I kind of feel like I want a break from all the meds. Dh is feeling more sceptical about Dr S, I think we'll go and see what he thinks about this round. Interestingly, the embryologist said my egg quality was really good, so I'm trying to hold onto that. I've got our embryology report that I'll send over to crp too.

Congratulations on your engagement 🥳💍 amazing news!! I loved planning our wedding, it was so exciting. Brilliant news 💕

Thanks for the info on the test @Unicorn9 I'm making a list of things we should consider moving forward. I'm so tired of having to pick myself up 😢

I'm sitting in the garden waiting for dh to come home, then we'll have an ice cream and we're having a Chinese tonight. Hope every one is well xx

Update, my hcg was only 5.2 but I did have a positive frer today 😔 looks like an 11/12dpo. But the clinic have called it negative on the hcg. So I'm not sure if it means it did try to implant but late and the beta hcg caught it on its ways down, or the frer is a false positive 🤷🏻‍♀️ I don't know what better, no implantation at all or a chemical? Ugh.
I'm going to test in the morning just for peace of mind, but either way, it's not going to be a good outcome xx

@VenusStarr I think a chemical is better than no implantation because you have peace of mind that you can get pregnant on ivf so you have a chance the next time right? I am yet to get a positive on ivf and it makes me wonder about whether timing is right as both have given me nothing at all. Take all the little positives you can from it... big hugs.