Immune/ NK cells - Pred threat 27

[LaurenAB94]

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Hi @VenusStarr - sorry you’ve had a stressful week. It must be great to finally get started?!

I had another negative test this morning. Had already stopped the progesterone so just awaiting a brutal AF now with that wasted lining! I’m having a bit of a sulk that my body didn’t utilise the 2 nice follicles that I was so exhausted producing!!

What meds are in the short protocol? I want to take the least amount of meds possible but not sure if just letrozole will do the trick.

Keeping everything crossed for you!

I'm sorry about the bfn @Badlydrawngirly big hugs. I felt exactly the same with my letrozole cycle.

I'm relieved to have got started, though I think this week has caught up with me, I feel really tired today.

I'm on 225 of bemfola. Got my first monitoring scan on Monday then I'll add centrotide in at some point to stop me ovulating. My clinic mainly does mild ivf, which I think is better for me as I have low amh levels, so we're not expecting a ton of eggs. Hopefully quality over quantity!! 🤞

To those who are pregnant, have you been advised to take the vaccine..? Cases in our area have started to rise and they're going to accelerate 18+ in the area now so it looks like I'll be offered it in the next few weeks which I wasn't expecting.

I don't know if I have an immune issue, I'm just assuming I probably have, but if I have then I'm concerned about taking the vaccine but I know very little tbh. I'm not quite sure what to do!

I hope everyone's upcoming treatments go well x

@VenusStarr it definitely sounds like the path you are in is right for you. I'm so sorry you have had and are having such a difficult time. For it to take so long to conceive in addition to miscarriage must be so difficult. I'm glad to hear the first injection went well 😊. I bet you can't wait for egg retrieval.

That's good about the intralipids. How many are you prescribed before and during pregnancy? I expected to need them but 5 lots seems like a lot but I'm happy to trust Dr S.

I hope your journey down goes well next week. Sorry to hear you dh can't go due to work

I started the hydroxychloroquine today loading doses after the all clear from Dr S. So pleased I dont need steroids and therefore not at any increased risk for covid19. Just need speak to my manager about the 7 more trips needed to Epsom, will feel better once I've done that, she has always been supportive but it will be one less worry

I hope all you ladies are ok and have a lovely weekend

Xx

@VenusStarr I really think mild is better and like you say it’s quality over quantity.

I had a call with my consultant today and he told me that the baby I miscarried was a boy with Trisomy 22. I burst into tears after the call. I knew deep down it was a boy from the start and once the sonographer said a large yolk sac could mean a chromosome problem I was sure that was it.
I know it means that there’s nothing we could have done which is reassuring in some senses but I am so worried that at my age it could happen again. Serum don’t do PGD testing unless you have a genetic issue, which we don’t thankfully but I am so scared about having another miscarriage because of trisomy, particularly as it could happen at a later stage or worse still we have to make the decision to terminate. I’ve read up that some Tri 22 babies do go full term but die shortly after birth.

Before the call I had decided with my acupuncturist to take a break as the letrozole and progesterone have really taken it out of me. I’ve had an awful migraine today and just brown spotting which has stopped. I had the same before my BFP in January which just feels cruel.

I found getting the news about my baby's chromosome test and finding out he was a boy really upsetting, it was like I'd lost him all over again. Sending you big hugs 💙 I named my little boy - my husband shut down and didn't want to talk about it, but it helps me connect to him. (I haven't named my others). I understand your concerns but hopefully the chromosome was a random occurance.

I'm sorry you had a migraine, hope it has passed now. I find when I get them, I feel rough for a day or so after, almost hungover. I think a break is a good idea, I'm not sure I would've gone straight into another medicated cycle. I'm glad I had a months break from everything and although I had spotting this time before af, I have had a proper period, so feel better for that.

Ttc after recurrent loss is a proper headfuck, look after yourself and go gently.

@Daffodil21 I saw that you can request which vaccine you have, if you choose to have it. I had my first jab but my second is early June and if I'm pregnant I'm unsure whether to do it. Mine was astra zeneca though.

I have got a corker of a bruise from my second injection 😕 I think my angle was off as I bled too but it all went in. Will take it slower today. Hoping for some follicles on Monday at my first scan.

Hope everyone is getting on OK xx ❤️

@Badlydrawngirly forgot to tag you x

@VenusStarr that’s exactly how I feel, like we’ve lost him all over again and it was 3 months to the day that we found out at the scan that his heart has stopped.

I’ve named him too, like you say it’s helps the connection. I didn’t know the sex of any of the others somehow this grief is worse than before.

I’m driving myself mad wondering if I should start another round of letrozole again today, have a break and get the biopsy or possibly just get the biopsy if I ovulate on my left.

I’ve been looking at clinics in the UK that will do PGA-T testing but I’m not sure if we will get enough embryos to make it worthwhile.

Good luck with your scan tomorrow!

@VenusStarr - it sounds like quite a journey you have been on. I'm so sorry, it must have been so difficult. (Understatement of the century). Really hoping this all works out. Keeping everything crossed. .I think the other half has something planned for my birthday as he keeps telling me to 'keep it free' but really hoping it's good news as it falls on the time I'd hopefully have a bfp as we just started ttc again last week, which is making me feel a little insane! But on the plus side, if it's not, at least I can have a little tipple! Good luck with the scan.

@Badlydrawngirly I'm really very sorry for your news too. 💙

@Rainbowdreams1983 that's great that you can start on the hydroxy!! How are you finding it?

The intralipids were absolutely fine! I'm a bit of a wuss with them going in but once done, it was quite relaxing. I need to have them until 16 weeks if I get a positive, although that feels almost unimaginable after so many losses. 🤞🤞🤞

Hope everyone is having a lovely weekend xx

@VenusStarr @Badlydrawngirly we also found out from histology of our last loss we would have had a boy. Like you have both said it felt like another loss. We were taken by suprise as didnt realise they could tell the sex so early on. We didn't know the sex of any of our other babies either, it particularly hit my husband hard as he had pictured himself with a son so many times.

I am thinking of you both. It's so hard to know which way to go next. I worry about making the wrong decisions all the time which I know is ultimately to try to prevent more upset and loss. Hope you have both had a nice weekend

Xxx

@VenusStarr @Badlydrawngirly
How absolutely heartbreaking for you both. I’ve had one tested and it came back normal female and the last one I didn’t want tested but the consultant said it may help so I got it tested. The consultant has set up a meeting to go over the results with me which makes me worry because they normally just send a letter and it’s a whole month away. In a way I don’t want to know. If it’s normal and I lost it again then what’s wrong. I don’t think knowing makes it easier does it? I also cried for days after finding out our results. I really do wish you so much luck and that your dreams do come true. I’m sorry I can’t say anything to comfort either of u but I do understand how distressing it all is.... big hugs.

@VenusStarr so sorry your post didnt show up on here for me earlier. I feel a bit off with the loading doses but been fine today just on the 400mg. How did you find it? Oh that's good to hear about the intralipids. I'm the same as you with needing them till 16 weeks if we get that far. I totally agree with you about it all feeling unimaginable after multiple losses. Just keep trying to tell myself that this time we are in good hands and there's no reason it won't work. However doesn't make the fear and anxiety any less real. Pregnancy after loss isn't enjoyable is it which is sad. My way of coping is distraction and avoidance as much as possible when all you can focus on is your body sensations. Xx

Could I ask a silly question... I had a failed FET in March and had a bleed after. I ovulated 14 days after the bleed and due my period on Tuesday but I have had some very light spotting. I’ve done a pregnancy test but it’s a bfn. Have any of you had a messed up second period after failed FET? I never spot before my cycle and know it’s not a pregnancy. Wish it was but doesn’t feel like it at all.

Hi @Unicorn9 I've never done a FET, this is my first ivf round. But I did have a good few days of spotting this cycle.l before af arrived. Hopefully your period has arrived now. This is what I find the hardest, knowing your period is on the way, I find it really triggering 😔

I've had my first scan and I'm responding as expected, which is not brilliantly. I've got 8 follicles in total but only 3 are really doing anything. I've added on another injection to stop me ovulating and I'm back again tomorrow. Hopefully I'm on track for 3 eggs 🤞 feeling quite low in mood today and struggling to believe we'll ever get there today.

I hope everyone is doing OK @Tumby @Rainbowdreams1983 @Badlydrawngirly xx

@VenusStarr keeping everything crossed for you! How have you felt on the meds?

My week is just getting worse - looks like I’ll be losing my job because of the time I’ve had off and the fact that I would need reasonable adjustments due to my auto immune condition. It’s very hurtful and disappointing as I am more than capable of doing the job.

I have a meeting with HR tomorrow and will be fighting it. X

Oh I'm sorry to hear that @Badlydrawngirly I hope that it isn't the case and they will put reasonable adjustments in place for you. It's just more stress on top of everything. I hope tomorrow goes well.

I think the meds are knocking me about. I feel shattered all the time and just quite teary today. Had a lot of twinges, so I hope something is going on. It's a bit of a mental headfuck, on the one hand I feel detached and it's surreal that I inject myself daily and on the other hand I'm so absorbed by it all that it's overwhelming. X

@VenusStarr I hope your appointment goes well tomorrow and they can get as many eggs as possible. I'm so sorry for how you are feeling. It's so much to have to go through emotionally and physically. Make sure you get in lots of self care and be gentle with yourself.

I've been having ups and downs. Felt off again on the meds but ok past 2 days so hope it continues. Just a matter of waiting for my period to come now and them book in for the first lot of intralipids.

@Badlydrawngirly that' so awful that your work are putting you through all this worry. It makes me so mad when on top of everything else work places can be so unsupportive when you have already been through so much. Are you in a union? I'd be fighting it all the way too. I dont see how they have a leg to stand on really.

I hope everyone else is ok ❤

Xxx

So sorry that you're struggling @VenusStarr. Be gentle with yourself as whilst I haven't been through the process you're going through, I imagine it plays absolute havoc with hormones whilst emotions are already running high. It really helps me to be kind to myself & I've got a little self sooth box (as odd as that might sound!) - it has lovely hand cream & bath stuff etc & photos of places I find calming/soothing. I use it when I get really overwhelmed emotionally! Best of luck for tomorrow, keeping everything crossed.

@Badlydrawngirly, that really is horrific and good on you for fighting it! I hope all goes well with HR.

Xxx

Hey @VenusStarr I just popped back on to see how everyone is doing, dont be so hard on yourself girl, ivf is so draining mentally and physically! Remember all you need is that one wee golden egg, quality over quantity! I got lots of eggs last time but still none of the embryos have worked so far so having lots doesnt really mean much? Is your egg collection today, if so good luck and I will be thinking of you 🤞

Well I finally phoned the clinic to book my next transfer but they seem to have crazy long waiting times and we are looking at June for my day 21 injection to stop my cycle and July for the transfer. I thought it would have been a bit sooner than that 🙄 back to waiting waiting, wish I could just get on with things!

Ah thank you @Luckyducky2 it's really difficult not to be hard on yourself, the hormones don't help!

I had my second monitoring scan today, I've got 4 potentials but one is getting to trigger size, so have 18,16,12,10mm and then a few smaller that are around 8-9mm. Got to go back tomorrow morning but they did my bloods as well, so I might be triggering tonight with collection on Friday if my lh is rising. But if I don't hear anything, they'll trigger me tomorrow for Saturday collection. Trying to trust the process. Feeling quite tender now.

I'm sorry you've got a wait for your transfer, hopefully the time will pass quickly for you. It's horrible when you're ready and then there's just lots of waiting!

Your self-soothe box sounds great @Tumby such a good idea 🙂 thank you for being kind.

I'm sorry your meds are knocking you around @Rainbowdreams1983 hopefully your wait passes quickly too.

I hope your HR meeting went OK today @Badlydrawngirly 🤞 xx

@VenusStarr that sounds promising! I will have everything crossed for you for this week. And try to relax, there is literally nothing more you can possibly do.......it's amazing just think of all the people working behind the scenes to try and make your dreams come true! 🥰

@Badlydrawngirly thats horrendous what your work are doing, I've never found HR much help before but pretty sure that could be grounds for discrimination if they won't provide reasonable adjustments? Xx

Thank you @Luckyducky2 I've had no phone call yet, so think it's likely Saturday, which I'm happy with. I want to get some warm socks and snacks for my post egg collection snoozing! 😂

I had acupuncture this afternoon and fell asleep. She's also said she wants to see me pre and post transfer and will charge me half price for both! So that's really kind and sweet. It's nice to know so many prople are on our side 🙏 ❤️ xx

All change, the doctor called just after 6. They're letting me go a bit longer in the hope that the smaller ones catch up 🤞 so I'm back on Friday for my last scan and hopefully egg collection Sunday or Monday 🙏 hope the delay doesn't mean that I lose any xx

Hi ladies I wondered if someone might have any advice. I have been ttc 18momths since last misscarriage and was advised to take 5mg pred from ovulation and then 15mg from BFP by a private fertility consultant in Ireland.. to my shock I got pregnant on the first go of 5mg! Now Reading threads that seems really low!? Did any ladies on this thread have success with 15mg? I should add this is being treated empiracally by the private doctor in Ireland. My recurrent miscarriage clinic in UK have me on pregesterone, aspirin and clexane from 6 weeks scan as one of my APS markers were borderline after my last miscarriage. Thanks for any words of wisdom!

Hi ladies, I wanted to let you know we had the safe arrival of our son on Monday. As a reminder, I was on the complex plan with Mr S (hydroxy, ovulation intralipids) and his standard drug plan (4 week ovulation, vits and asprin) and regular scans. We fell pregnant on our fourth cycle and was successful. Prior to Mr S' intervention, I had 3 losses - 1 second trimester at 19w5 and two 1st trimester at 12w and 10w.

I've read some of the stories recently so I hope it's ok to post. But having read older threads to give me hope, I always found it reassuring to know people had experienced successes even when I was still struggling to make a baby when I joined and started posting. Sending love and good wishes to all. Katy X