Immune/NK Issues - aka Pred Thread no 26

[KtAgs]

This thread has been running for many years and has proved invaluable for so many of us who have suffered recurrent miscarriages as we go through this incredibly tough journey.

Discussions cover immune issues, NK (natural killer) cells, thyroid issues, PGS and many many more.

Welcome to the group no-one wants to be in

@HoldingOn2Hope*@Crystal2020 @Wishing5tar*@hrtbrk2 @VenusStarr @jellystar23 @3verhopeful35 @hazlet2 @whyisthistakingsolong @NICK7nick7 @LR12 @Lalaifa @lookingforanswers86

Please tag anyone else I've missed.

Thank you for starting the new thread.

I’m 10 dpo today has got a negative. Going to check again tomorrow morning to be sure before coming off of meds. Absolutely gutted. I think it being baby loss awareness week this week, and my due date next month for my most recent loss, is making it a lot harder this month. I’ve had lots of pregnancy symptoms but think it’s just the progesterone.

Good luck with the testing @Lalaifa and @HoldingOn2Hope, really hope it is your month this month.

Good luck for your scans @LRL12 and @KtAgs xx

@NICK7nick7 I got a negative today at 13dpo, super gutted too. Spent most of the day crying, I think it is because of the progesterone and then the baby loss awareness week thing too. Was thinking I must be pg. Hopefully, we'll have better days soon. Take care of yourself. X

@Lalaifa oh no, I’m so sorry, it’s just so hard isn’t it. I got another negative today so coming off of the meds. I couldn’t sleep last night as I felt so wired on the Prednisolone along with worrying about the test today. I’ve taken the day off today as just feel rubbish emotionally and physically.

Dr S originally said to try for 3 months and then he wants to see me for a review if not pregnant. Is this just due to needing to do a medication review before prescribing, does anyone know, or does he start then looking at why we haven’t got pregnant yet? xx

Hi @HoldingOn2Hope yes, almost 37 weeks. Been a few ups and downs over the last few weeks but hoping all will be fine. I see you’re testing this week - good luck! Hope everyone is well and coping with this crazy year xx

@NICK7nick7 sorry to hear about your BFN & the other ladies too! The 3 month point is usually just to check you haven’t had any side effects to the meds and he will re-prescribe. I remember he did ask how long it usually takes me to fall pregnant but unless he’s concerned about time ticking on, I don’t think he’d move you onto superovulation just yet. I could be wrong though ☺️

I’m just feeling really mehh lately. One of my besties had her baby last week and it just brings with it a wave of ‘will this ever happen for me’ feelings. It’s been 3 years this month and considering it’s now been 15 months since we were last pregnant I can’t actually see past this miserable fog if that makes sense?! Sorry for being all doom and gloom! 😥

But... first month of goal-F was a success. I had 2 follicles on the left side. I had my LH surge on the cheapy strips on Monday night, temp rise with Ovusense which confirmed ovulation on Tuesday but Dr S had me trigger on Thursday night 🤷🏻‍♀️ So not sure if I’d have already ovulated on my own by then. Currently 8dpo according to Ovusense and Dr S wants me to test on CD24 which will make me 14dpo.

Good luck for your upcoming scans @KtAgs & @LRL12 xx

Thanks @HarrietM87 - I wasn't sure who to tag as there were so many people so I'm glad you decided to post again.

Thanks for all your well wishes ladies. Getting seriously scared now. Been quite tearful actually - I had a dream I miscarried last night - it was very vivid. Hopefully everything is fine. I have everything crossed for myself.

Thinking of all you ladies testing and it really is a rough week with BLAW. I'm taking an Ostrich approach this year and avoiding a lot of it. I was so engaged with it last year. I just need to protect myself I think. xx

Morning ladies it was a BFN for me today 😑 had a good number of follicles too. My does will be reduced this month so I don't know what to expect 🤷🏻‍♀️
@KtAgs I hear you, I've had to avoid BLAW posts this week too, I know it's to raise awareness and educate but I just felt I was consuming all the negative stories and then thinking about them too much. I know you must be a little anxious, I'm keeping you in my prayers 🙏🏽
@HarrietM87 wow not long to go at all! Look forward to you updating us when your bundle of joy arrives :)

*dose

@KtAgs hope today goes/has gone well xx

Finally had my genetic report, baby was normal and a little girl ❤️ So much harder knowing the gender than I’d anticipated. My consultant sounded a little annoyed that I’d taken the step to see Mr S. Has anyone else noticed this? He had previously advised me not to spend thousands on non-proven methods but couldn’t give me any advice on where to go from here either.
I wonder how often NHS consultants actually see and treat women like us. Whereas Mr S sees it everyday 🤷🏻‍♀️

Thanks for all your well wishes ladies. It means a lot. Scan went well. Measuring at 9w. I'm delighted. I'm gonna book in with my midwives now. I've been too scared to yet.

@Jellystar23 I'm glad you've got results but it is hard finding out the sex. How do you feel knowing there were no chromosomal issues? Go gently with yourself.

My GP was a bit funny about Mr S but my consultant suggested I go to see him in Epsom on the NHS as a next step before I'd decided to go private. My consultant is a very compassionate and nice man though - he's not typical of my interactions with health professionals on this journey. I think Mr S is very marmite and the cost is eye watering but at least he's doing something rather than saying nothing is wrong and to keep trying.

@harrietM87 I'm glad you're doing ok but sorry its been a bit stressful these last few weeks. Let us know how you're getting on and good luck with the last bit. Xx

Oh I’m so happy for you @KtAgs. Wonderful news xx
Chromosome wise I feel quite hurt that there is no obvious reason for me to be going through all this pain, but also so glad I went with my gut instinct 6 weeks ago to book my appt with Mr S. My initial plan was to wait for this result and go from there but now I’ve had the tests and started some sort of treatment, I think it’s helped me handle today I bit better.
100% agree with him being proactive. This whole speciality seems like witchcraft whereby nobody can explain why things happen or work, but I’m at the stage where as long as it does I don’t really care whether a huge clinical trial has found it successful.

Aww wonderful news @KtAgs so happy for you! Xx

@Jellystar23 Sending love ❤️ it definitely feels better to be being proactive on this cruel rollercoaster we’re all on. Here’s hoping Dr S helps to achieve your rainbow xx

@KtAgs amazing news I'm glad it all went well :)

@Jellystar23 Awww it does make it all that more real knowing the gender, I know it was so upsetting for me so understand how you feel. Be extra kind to yourself. And yes my GP wasn't keen on Dr S however my nhs consultant told me to believe in his methods and not lose hope. He's an amazing man, makes me bawl every time I see him. You do what is right for you. As much as I've had a few communication issues with the clinic especially during the last pregnancy/miscarriage I must admit Dr S gives me confident each time I see him. I don't think he's sometimes aware about the miscommunication with the nurses as something came up on my last appt which I had communicated with nurses and they didn't get back to me and he really did rip them apart in front of me which was so awks!

Does anyone take evening primrose oil from period to ovulation? I've read on many forums it's meant to help produce more CM to help the swimmers along!

@KtAgs That's amazing news! I am so happy for you. Please, keep us posted on how it progresses. xx

@Jellystar23 heart-breaking that you had to find out your baby's gender and on BLAW week as well. I hope you are ok. I am glad that you find solace in the fact you decided to see doctor S. I do too.

I am having a bit of a low mood today, as feeling hormonal and period hasn't turned up yet. I am overthinking but I have done two tests which have been negative. So now to wait for af. This reminds me when I first saw af in forums I thought it meant "as fuck". How silly of me! haha.

I hope everyone else is ok. I have never tried evening primrose, although it is supposed to help with cycles, pms, etc. I think I have respect for these herbs but it is safe to use on the first half of cycle.

@KtAgs SUCH Good news!

@Jellystar23 Hope you are ok. I am glad starting the medication and following Dr S's plan helped a little x

@KtAgs That is such great news, really thrilled for you!

@Jellystar23 I'm glad you found out the result of the genetic testing, but I know how crushing it is to know the sex. I'm really sorry 😔 I totally understand how awful you must feel knowing that there wasn't a chromosome issue but I do think that both answers are equally crushing. I only say that because I was praying for a 'reason' and when we found out our last one was a trisomy I actually didn't feel the relief I thought I would. I just felt very angry that we'd been dealt even more bad luck. Hope you're doing okay.

@Whyisthistakingsolong Have you done your first Humira injection yet? How did you find it? Out of interest, did Mr S tell you to self isolate? I was prescribed mine when Covid rates were much lower back in early September, so I was just told to be careful. I'm not totally isolating, as I think that would be too depressing right now on top of our recent bad news, but was curious to see whether you are?

Great news @KtAgs. This is lovely to hear. Can you remind me what protocol you were on?

@Jellystar23 crushing to know the sex in a way. It cements you made the right decision to see Mr S though. I am awaiting karyotyping from recent MVA, but have asked to not find out the sex, not sure if it can be avoided though if I want the report?

@Everhopeful35 Ive just hot back from a week away so am going to collect the meds next Sat. Mr S didn't use words self isolate, but said be very sensible, don't go to supermarket/mix with people and wfh. My son is still going to nursery though.. Were you advised the same? I hope you're doing OK. Don't give up hope
X

Thanks @whyisthistakingsolong . I was on ovulation intralipids (I didn't like the side effects of the steroids and the threat of a 2nd wave) and hydroxychloroquine because my NK cells being complex (high generally and high in pregnancy).

I asked for the sex to be removed from my report and they left info in annoyingly - 'a normal female complement'. X

Really helpful group here ladies, thanks so much

@LRL12 thanks for the tag and @KtAgs for starting the new thread! I had my first scan today and measured 8 weeks 3 days and saw the heartbeat . So relieved and I'm trying to believe there is every reason that it should work now I'm on the treatment. The waiting is so hard though! @LRL12, I hope your scan goes well this week. Much love to everyone.

That’s great news @Hippo20 was this your first scan? Wasn’t sure if yours was different for NHS? Mines Thursday excited but really anxious / worried nerves etc I’ve not seen a heartbeat before so just have everything crossed it’s ok.

X

Sorry you said was your first scan 🤦🏻‍♀️

Yes it was my first scan. They initially said I'd have to wait until 12 weeks because of covid but thankfully changed their mind! I was so nervous before the scan too, although it's still the 12 weeks scan I'm most nervous about as that's when I've found out I lost the babies before. I really hope it all goes well for you on Thursday! It'll be a great milestone if all is well. Fingers crossed for you x

I mc just before my 12 wk scan,
I then booked early scans for the next 2 at 8 weeks but again mc days before. So this will be my first scan,
Interesting that they only wanted you to go at 8 & 12 they wanted to see me 6,8,10,12 & 16 just seemed a lot,
I’ll let you guys know Thursday fingers crossed all is well. X