ERA/ALICE/EMMA testing thread 2

[seven201]

Link to the old thread
https://www.mumsnet.com/Talk/infertility/4187520-era-testing-after-multiple-implantation-failures-anyone-had-it-done?msgid=110302437&utmsource=mentions&utmmmedium=email&utmcampaign=2020-10-19&utmmterm=You+have+been+mentioned+in+a+post&rei=438192#110302437

Welcome to the new thread. Anyone welcome.

@Janefx40 I hope so 🤞 at the very least I hopefully will have confirmation my microflora isn't as bad as it can get before the next transfer.

@Gardenlady543 I know you've seen all the specialists but I did see quite a knowledgeable nutritionist who gave me some advice on micro flora and implantation. She also had me do the invivo vaginal swab, which showed various problems. I self managed all of this as my ivf consultant is not a believer in all of this stuff so I got metronidazole and doxycycline and took both of those back to back and then went hard on the probiotics. Including putting one called invivo bio femme v vaginally and also taking orally (nutritionist advised). It has l crispatus which is apparently quite key for implantation. It may well be a coincidence that the next transfer worked as I think mostly our issues were age and chromosomes. But who knows.

@whatcangowrong I've had 3 different antibiotics, 3 different vaginal probiotics and 3 different oral probiotics :( it looks like if it's abnormal again I'll need the intrauterine antibiotics.

I'm sorry, I've been away from the thread for a while.

@VenusStarr oh my goodness. I am absolutely gutted for you. Life is so fucking cruel sometimes. I hope you and your dh are able to give each other some support. So sorry.

@Gardenlady543 I'm sorry too, although do keep on with the meds etc until official test day. It sounds like you've found a way to cope in doing the prep work for more investigation into your microflora. It sounds like the man you spoke to really knows his stuff. I'd go with believing what he says.

Thanks for all the love and support ❤️ I was second on the list, so just waiting for dh to get me. I woke up crying and shaking 😢 in quite a lot of discomfort, they're slacking on the pain meds. They said I could go home at 1pm but I've still got my cannula in. They said it was straightforward and they've sent the baby off for testing. I'm praying so hard they can get some results, either way will help me I think.

Hope everyone is OK xx

@VenusStarr I'm so sorry. Such a horrible place to be. None of us wants to be there. Hope they can give you more meds. No need for you to be in pain. Rest up this afternoon and be nice to yourself xxx

Sending you hugs @VenusStarr that's awful about the pain meds not being enough. I hope you can recover quickly. Thinking of you.

@VenusStarr. Bless u. Tv , cuddles, cake. Be kind to urself xxx

Big love to you @VenusStarr. Well done for getting through today.

Hope everyone is ok. Feels like the briefly positive thread is a lot more subdued, life isn't fair.

Sending you @VenusStarr there are no words.

@whatcangowrong agreed. That’s ivf for you. The ups and downs and uncertainty. How are you? I’m just full of anxiety. Scan in 2 weeks. No real symptoms which isn’t helping the anxiety.

@Gardenlady543 are you at OTD? I’m so sorry it looks like it hasn’t worked. I think your consultant sounds really good though, he has a plan and he’s positive it will work for you . I hope you are ok x

to everyone else.

@Dochas1211 I'm ok thank you. My scan is a week on Monday, look fwd to knowing one way or other if we can even hope. I haven't had previous losses bar one chemical, but I still feel like I have lost my innocence in a big way since last pregnancy. I was quite blasé about things then. I am starting to feel mildly queasy so maybe that is good. I had no symptoms in my last pregnancy so I wouldn't worry about that specifically.

Holiday plans up in the air as we were supposed to go to South Africa, doh! So not sure how we will make the weeks between 6-8 go quicker now :-/

Hi ladies @Dochas1211 and @whatcangowrong glad you guys are as ok as possible. I've been wondering how you both are. It's a long wait for that scan isn't it?!

Yes we've not had much luck on this thread recently but still rooting for you both and wanting all good things to happen for you.

Xxx

Hello everyone. I hope everyone is as ok as they can be. I am just home from a night out and am absolutely pissed. Probably shouldn't be as I could be around ovulation but I've had enough of being good!

@whatcangowrong and @Dochas121 hang on in there. Are you both ok?

@Gardenlady543 how are you doing? Is it tuesday coming official test day?
@VenusStarr has the pain finished? How are you doing?
@Janefx40 how are you?

Everyone else?

@seven201 hooray for being pissed! Hope you had fun and aren't feeling too rough today.

I'm fine. Bit nervous about all the Covid around and wondering whether I'd rather catch it now than get it when we're meant to be starting our FET. Not sure I could cope with more delays!

Love to everyone else x

Hooray indeed for being pissed @seven201 hope you had lots of fun!

I'm feeling ok, weirdly I sort of keep forgetting that I'm pregnant, doesn't feel at all real which is probably a good thing until the scan.

@Janefx40 how many embryos do you have to try in the new year? Worth being a bit careful re covid but try to also enjoy yourself and relax! Actually my clinic didn't ask you to test at all just made you sign a form saying basically that you didn't have symptoms. Which I thought was quite good as it would just be so crap to have to cancel if you hadn't even noticed you had covid and were only testing to go to the clinic!

@whatcangowrong I'm glad you're able to forget about it for a bit. It can be overwhelmingly stressful otherwise. I have no idea how I got through those early weeks. My anxiety was through the roof.

We have two embryos so will transfer one at a time. X

Hi everyone.

@whatcangowrong that is a seriously good skill to have - being able to sort of forget/carry on.

@Janefx40 I've got two left too and also hoping to use one in the new year, although I'm yet to be booked in, so probably later than you.

@Gardenlady543 how are you? Have you done more tests now it's nearing official test day?

@VenusStarr how are you doing?

Xx

Ah I'm not sure it's a skill @seven201 I think it's more that I completely detached from the last transfer having been over invested in all the ones up to that. Scan is a week today and I'm starting to feel a bit more on edge, partly as I had some nausea last week which I feel has subsided. But it is probably a bit early for nausea so could have just been unrelated... trying not to stress!

Hope everyone had a good weekend.

@Gardenlady543 hope you're ok whatever outcome is currently.

I last tested on 9dp5dt but have tested today 12dp5dt and it is negative again, my OTD is tomorrow, so it’s pretty much over, but I will keep taking the medications and test as I have been instructed to. Overall I’m very sad, and while I let myself have some degree of hope, I have never had a positive before so the chance of suddenly getting one wasn’t exactly high.

I’ve been doing a lot of thinking and I’m not really sure where to go next, the menstrual blood test will help me decide I suppose. I have been in contact with two people who had never had a positive, both had 9 unsuccessful transfers and then moved on to a gestation carrier, both had success the first time. I guess it’s difficult to decide how many euploid embryos I will continue to waste in myself when there is clearly some unknown issue that prevents implantation.

How many transfers have you had @Gardenlady543 ?

@whatcangowrong 2 years of trying without a single positive, fresh cycle yielded 9 high quality blasts, 83% were euploid when tested. 4 IVF transfers in total, 2 high quality untested, 2 euploid, all BFN.

It's so tough @Gardenlady543 as of course you want to carry your own child and so many people take a while to get pregnant both with and without ivf. I get why you are feeling a bit despondent but in your shoes I think I would be doing more transfers before making that call. Anyway you have a plan for next thing to test and maybe there will be more answers. If you want yet another opinion, Melanie Brown was the woman who I did the swab and probiotic plan with. She sent me loads of info on recurrent implantation failure and the microbiome.

Would you consider double transfers? Do you have embryos at different stages? I think that can be a way to increase chances that one of them hits the window for implantation.

In my case it's utterly confusing as I had all those failed transfers and then on this last one when I'm sure I started my progesterone 24 hours late it worked (for now). It's almost like I did an accidental and completely blind ERA.

I’m so sorry it’s a BFN @Gardenlady543 would you consider doing another egg collection given you had such great results from your first round and just bank some more embryos. Then work on the lining or other investigations into implantation?

I hope you are ok.

Hope everyone else is doing ok too. X

@Gardenlady543 I'm so sorry. It's just heartbreaking. It's so stressful too trying to make decisions about the future. We've got some information but there are always so many unknowns that it's so hard knowing what to do. Happy to be a sounding board anytime. Sorry you're in this situation x