IVF January/February 2021? continued

[hopefully21]

I just set this up as we reached the limit in the other one.

4dp5dt

@thirteen92 I think I can see what you mean!

🤞🏼🤞🏼 when you next do a test it's a strong line 💞

@Gardenlady543 4dp is really early though. I see people getting squinters from 5dp. I have no idea how sensitive the clinic tests are. Try again in 48hrs if you’re going to keep on testing? Hcg doubles every 48hrs. I’m holding out now lol

@thirteen92 what kind of test have you done? Is it a CB fertility monitor test?

@Gardenlady543 it’s the test the clinic gave me. It does remind me of an ovulation test!

@thirteen92 oh that’s good then, it looks like the kind of test that goes into a CB monitor, those ones can only be interpreted by the machine. But obviously it’s not one of those if the clinic gave it to you! I can see a bit of a line too, good luck 🍀

@Gardenlady543 staying positive for us 🤞🏻

@Gardenlady543 4dp is soooo early, my last round I only got a super squinter at 6dp5dt but it was a clear line the next day, for some it’s as late as 11 or 12dp5dt before they get a BFP I also heard it might be a bit later with frozen embryos.

Thanks @kikisparks I really hope I don’t have an implantation issue, because it’s a 1,1 embryo and when it was thawed it hatched straight away so the embryo appears to be a good one, I can’t see it suddenly arresting. I can’t help but think the issue is me. I feel quite sad today, with my fresh cycle it was tough but I got 9 blastocytes so it was worth it. I’ve been ill with all the meds in this FET I will be devastated if it’s all been for nothing.

@thirteen92, I see a very faint line on that. Tentatively excited for you. It is very early as everyone says. I tested at 4dp5dt and got the faintest hint of a line. Trigger had been out of my system. I'm 6dp5dt today and got this much stronger line this morning. Sooo beyond excited. This is the first positive test in well over 10 years I've had (I have a 12 year old DC naturally conceived). Still pinching myself.

Fingers crossed for you!

And fingers crossed for you @Gardenlady543! Still lots of time.

Some good news this morning! Let’s the rest of us stay positive! I was tempted to test this morning but I want a definitive answer one way or the other so I’m waiting until Wednesday. My other half is really hungover this morning from a Zoom poker night so that put me off testing too 😂

Ah congrats @jonrik loving all the BFPs, hope this is a lucky month!

I have my EC on Tuesday and they've said no gel nails - does this include toes?
This might be a stupid question...

I still have my Christmas toes on 😞

@jonrik oh how exciting! I’m super excited for you. Let’s hope mine isn’t trigger 🤞🏻

@foodiefil
They said no make up too, but I wondered about mascara 😂... I look horrendous without makeup

Hope you’re ok @Gardenlady543, still time
Good luck @jonrik and everyone who’s testing xx

@foodiefil I think they need to be able to see your nails for signs of distress or lack of blood supply when you’re under the anaesthetic so I’d take the polish off. I was also told no deodorant or perfume as it can harm the eggs.

@foodiefil it’s because they need to monitor your oxygen saturations when you’re sedated, a oxygen saturation probe is put on your finger tip and nail varnish/artificial nails can affect it’s ability to pick up your sats. I don’t think they would mind about your toes, I’m pretty sure I kept my socks on during the procedure.

Thanks @IVFat43 to be honest I’d rather assume it’s negative and then get a pleasant surprise, although would be very sad to end up with no success again having had two separate transfers with a very good (last cycle) and excellent (this cycle) blastocyte.

I’m contemplating asking the clinic to start PGT-A testing during this 2ww, I decided to hold off before this transfer, I’m 35 and my specialist told me The chance of an aneuploid embryo was 1 in 3 but then the clinic gave me a handout that said it’s 1 in 2. If this cycle does end up to be successful then it will be useful for future transfers, if it is not successful then it means that I don’t need to delay planning the next cycle as testing can take a few weeks.

I’m lucky that I got a lot of good embryos in my fresh cycle:

• 1,1 fully hatched 10/10 - just transferred
• 2,3 8/10- transferred in the unsuccessful fresh cycle

I still have these frosties:

• 1,1 hatching 10/10
• 1,1 expanded 8/10
• 1,1 expanding 8/10
• 1,2 expanded 10/10
• 2,2 expanded 9/10
• 2,2 expanded 9/10
• 2,2 full blast 5/10

So the PGT-A testing will end up costing just over £3k for these 7.

@Gardenlady543 thank you- it's just my toes so I'll check but hopefully ok because it's an ordeal to remove.

Do you mind me asking what this means?

• 1,1 fully hatched 10/10 - just transferred
• 2,3 8/10- transferred in the unsuccessful fresh cycle

I still have these frosties:

• 1,1 hatching 10/10
• 1,1 expanded 8/10
• 1,1 expanding 8/10
• 1,2 expanded 10/10
• 2,2 expanded 9/10
• 2,2 expanded 9/10
• 2,2 full blast 5/10

I'm sorry I haven't got to the stage where I have any embryos or anything so don't know what this means.

@Gardenlady543 we’re doing PGT-A, with the hope of testing 2 at a time to keep costs low, we want 2 transferred..

Your results seem so good that I would be surprised if it didn’t work, but there’s so many hurdles to overcome that I understand you’re protecting yourself, I’m very similar. Least you have a good reserve..

I can’t wait to hear how many I get tomorrow, I don’t think I’ll get the detail you have..it’s amazing to see such detail..my clinic have been good but depends who you get with how much they share, and I just want to know everything ☺️

@foodiefil your embryos will be graded by the embryologist, my clinic uses a number grading system, you get two numbers per embryo- 1 is the best, followed by 2 and then 3. So 1,1 is the best grading. Generally anything with a 3 in, may be viable but may not be deemed freezable.

The embryos also have a stage of development- so they will be expanding and then expanded and then hatching and then hatched. The further along this progress, the better.

My embryos were in an embryoscope, so I have got a number out of 10, that is the caremaps score- 10/10 is the best.

So the embryo that I’ve had transferred is the best that you can get- 1,1, fully hatched and 10/10. But, this grading does not tell you if there is aneuploidy present (this is where there are slightly more or less chromosomes than expected- these tend not to implant or result in miscarriage or result in a condition like Down’s syndrome). The grading also doesn’t tell you about abnormalities within the chromosomes like mutations that can also result in an unsuccessful transfer.

Some clinics use the number grading system, others use letters. You’ll only find out the final grading at day 5. You should ask if your embryos are in an embryoscope as this provides more information.

Thanks for the kind words @IVFat43 I know I’m super lucky to have got so many high quality embryos from a cycle, but if none implant then I may as well have none. It makes me wonder why things never happened naturally, unless there is an issue in me affecting implantation, I just can’t understand it.

Re: all the details... lol I am a control freak, I have a paper and pen ready for when they call and I ask everything. My embryologist had everything in order of the well number and when I asked so many questions she was like “ok I’m just going to read everything out in turn”. These are your potential babies, so I’d advise you to ask everything that you want to know. So for each one I ask- what is the grading, what’s the embryoscope score and what stage of development. I think the grading and stage of development is combined in the letter grading system and some people may not have their embryos in an embryoscope.

I guess the reason I’ve been on the fence about PGT- A is because my clinic charge a fee of over £1k and then about £300 per embryo, so it’s kind of a all or nothing decision, if I may need it more than once.

Thank you for explaining @Gardenlady543

Great you got so many good quality embryos. I really hope it's good news for you soon ❤️

@Gardenlady543 thanks for the questions to ask, I’ll make a note of these!
A friend of mine who struggled realised it was the position of her womb which they sorted l, two others struggled with implantation and once they both had the “scratch” it worked both on their 3rd attempt.. it’s so hard working it all out..

We’ve paid the fee £1,150 already, then it’s £295 per tested embryo.. but I’m hoping I can have 2 tested and keep any others frozen for another round.. it’s definitely an expensive game! 🙈