PGD treatment

[Pharaohhoundbek]

Hello

I’m 29 and have just started PGD treatment. Both myself and my partner are fertile so we are hoping this works in our favour with the treatment. He has a genetic mutation which creates tumours so we are going down this road to prevent our children having the same gene. I wondered if anyone here has had this treatment? 3rd day in and I’m very nauseous! Hot sweats at night and general poorly feeling. Has anyone else experienced this?

Would love to hear from anyone who has had successful births with PGD too :-)

Thanks in advance,
Bek x

[Ginandtonic31]

Good luck this morning @Hoppy1985

[Hoppy1985]

@Ginandtonic31 thanks. I am feeling tougher than after the previous two times, tender and crampy but they collected 24 eggs which is so much better than last time. I'm still so nervous though worried that none will fertilise after last time. Just keeping everything crossed for good news tomorrow.

Have you just got to wait till you get your period now so you can start protocol for your transfer?x

[Ginandtonic31]

That's excellent @Hoppy1985! Think positively for now. Look at the difference between my two rounds! Each round is different how you feel too. First round I only got 4 and felt dreadful. Second round 27 and was fine! Went straight out of hospital and for brunch!

I'm back on the pill so can start whenever I've done 21 days of the pill after an appointment with the nurse. My appointment is 20th April but I'm going on Holiday in April and May so just looking forward to those for now and will worry about a transfer when I'm home.

[PandaBlue]

Hello, I'm wondering if someone might be able to help me please re PGD on the NHS?

DS was born with a physical disability. It's definitely genetic as it's very rare, but another close family member also has the same disability. So I'm a carrier and most likely 50% chance of passing it on. We are going through genetic testing, aware this might not result in anything. But still clinging on to hope that something is found and I can have PGD for a sibling.

My issue is I'm 38 this year, and nhs cut off is 40! This doesn't give me much time. Can I only get referred for PGD once a genetic diagnosis is made / HFEA approve the testing? Our condition is not on their list yet and I know this also takes time!

Any advice on anything I can be doing to help speed up the process? Or do I literally just have to wait for a genetic diagnosis before I can get the ball rolling anywhere else?

[Ginandtonic31]

@PandaBlue hi! I think it's just a waiting game! They will need to find the gene first and also get it licensed before PGD can go ahead. The only way I can think may speed it up is going private but I'm not sure if that would speed up the genetic testing and also the license would still take the same amount of time.

[PandaBlue]

Thanks G&T. That's what I expected really, just thought I'd check if there was anything else I could be doing. Just feel so helpless and stuck in limbo right now, with a lot of ticking clock time pressure!

[Ginandtonic31]

@PandaBlue I know the feeling! I think we were an exceptional case so don't want to put you off but it took us 4.5 years to get to this point so I know how it feels 😫

[Hoppy1985]

Hey @PandaBlue It took a little over a year between our first referral and starting. There wasn't a licence for my condition yet, that took about 6 months to get. But like G&T said, I think it's all dependent on your condition, how easy it is for it to get approved.

@Ginandtonic31 I have 8 fertilised, which isn't great given how many I had, but still 8 times as many as last time's none and 4 times as many as first round. They said only 21/24 were mature enough to inject.

Now just have to wait and hope 🤞🏼🤞🏼🤞🏼

[Ginandtonic31]

Excellent @Hoppy1985 I would have been happy if I had that number fertilised and still more than before for you. So day 5 wait for the call now?!

[Hoppy1985]

@Ginandtonic31 yep 😫 they said they will call on Sunday afternoon

[Ginandtonic31]

I hate the waiting @Hoppy1985! How long then for your results?

[Hoppy1985]

@Ginandtonic31 IF any make it to freeze they then said 2-3 weeks to test x

[Ginandtonic31]

Is it guys @Hoppy1985? I know you've said but I can't remember! Sorry

[Hoppy1985]

@Ginandtonic31 yep guys! X

[Ginandtonic31]

@Hoppy1985 did you hear more today?

[Hoppy1985]

@Ginandtonic31 hey. Yes I have 4 for the freezer so now 3 weeks to wait for the test results x

[Ginandtonic31]

Excellent @Hoppy1985! I'm sure you will hear in the next 7-10 days. Guys seem really on the ball at the moment.

[Ginandtonic31]

Have you heard @Hoppy1985 ?

[Hoppy1985]

@Ginandtonic31 yes I heard Monday...2/4 are healthy so on to FET it is!

[Ginandtonic31]

Ah that's good. True 50/50 split.

[Teddybear45]

From what I was told PGD is just a screening tool and you have to have good egg reserve (and have a good amount of embryos) to make it worth your while. So ensure you are on the maximum dose of stim drugs that your consultant is willing to provide.

Another option is to do caryotype testing. It’s cheaper than a possible failed cycle in case all the embryos have the gene, but again possibly only available for named conditions depending on the clinic.

[Hoppy1985]

I did worse on a higher level of drugs during my cycle so not sure that's always right @Teddybear45 I think everyone reacts differently, but yes the PGD part is just screening.

[Ginandtonic31]

@Teddybear45 as @Hoppy1985 max was set always best! I was on a lowing dose and got 27 eggs. Thank god it wasn't the max dose!

[grumpycat2019]

Can I please join? We at looking at PGD at guys after our first baby was born with nf1 (my fault). I had completely forgotten about my Nf and now my darling boy has it. I can only hope he's as mildly affected as I am.

It's all so overwhelming at first, all this terminology.

[Ginandtonic31]

@grumpycat2019 hi! Of course you can join. It isn't always active, but I'm always around to answer any questions!

How are you getting on @Hoppy1985?