Immune/Natural Killer Cell treatment for those ttc or pregnant. (AKA the 19th pred thread!)

[Seekingmiracles]

The new thread for anyone ttc or pregnant with immune issues or natural killer issues. Welcome ladies!

Thanks harrietm for asking.. i m still waiting for an appointment with the fertility consultant to start embryo transfer. So havent started on prednisolone yet, only started on aspirin and the multivitamins.. Aiming to start by next month atleast..
Good luck to u..
Hope everyone else s doing good..

Hey

I cheated and tested on Sat BFN and low and behold af has arrived today right on schedule .....As we aren't officially TTC I'm not on any different meds just being weaned off carbimazole and beta blockers

Good luck everyone! Maybe see you next time I'm on the naughty step :D

Hi Harriet, I'm fine thanks. Strangely haven't had any notifications for week and now boom. Catching up on all of these and sorry to hear there have been some disappointments.

Pickled, great to see your pregnancy is looking like a sticky one!

Turned out I wasn't pregnant last month but I am ovulating any day and BDing loads so fingers crossed!

Good luck all x

Fingers crossed for this month poppy!

Hope you're doing ok with the waiting hopeful? Have you had FET before? Sorry was trying to track back, but couldn't see. I hope you have the appointment soon.

Yes starshine, I hav had a FET before but it also ended up in a miscarriage but this time it was due to a chromosomal abnormality :(
Going crazy with the wait times but end of the day hav no other option with the NHS..should get an appointment by July!!

Hey Starshine, thanks. Chin up and all the best for more encouraging developments!

All, I've stopped having most of the pred side effects; but of weight gain and occasional heart pounding but it's def settled down. Cycles looking good again too. I'm only on 5mg so maybe that's why. Incredible how many different side effects there are though, according to the leaflet.

So I got a flashing smiley today on my opk straight after sex, then this evening I got the solid smiley indicating peak fertility! Hope that still counts as sex on the right day because we are knackered and have DP's kids and friends staying tonight. We've been having sex every 12-24 hours this week which I think is fine because he has no sperm count issues. Should probably push for one more shot in the next 24 hours though!

Well done poppy! That is good going! Hopefully plenty of swimmers there! Do you do the opk tests at different times of the day? Haven't thought of doing that, only do it in the morning so always thought I could miss a bit of peak time!

Completely understandable hopeful! Hope you're doing somethings to take your mind off of all the waiting- easier said than done I know x

Starshine, it's the clearblue ones and once you get the flashing smiley you can test every four hours hoping for the solid smiley. Before the flashing one you have to do it first thing.

Just had time to catch up on some of the ports I missed and sorry to read how bad a time you've been having. It really does feel like a no win situation sometimes, doesn't it? There's so much to fret about while TTC and all over again when pregnant. But all we can do is keep going; no reason why the next BFP and success story won't be you!

It most definitely feels like a no win situation at times poppy! Feel like I am constantly waivering as to whether just give up or not as really don't know how I will cope if either we don't get pregnant or then miscarry again! I know- must stay positive about it all!

Thanks for the tip about ovulation kits- that's the ones I use and didn't realise you could test every four hours one you have a flashing smiley face! Will try that this month! Fx for all those swimmers for you poppy!

Wow poppy every 12 hrs?! Well done!

Sorry about the wait hopeful - hope your appointment comes in soon.

I'm 6dpo today. Actually feel like I'm counting every second! It was my last day of pred today as well. The clinic said to stop after 10 days even though I started early, so hoping it's not a problem if I do get a bfp. The only side effect I've had has been extreme hunger - hopefully that will wear off quickly!

Starshine, only you can make that decision. I've considered it myself but it occurred to me that given a choice between definitely not getting what I want and hopefully getting what I want, but with the risk of disappointment, the latter made more sense. Hope you're just having a rubbish patch and will feel more hopeful soon. Maybe even pregnant!

Harriet, yeah DP was away for two weeks and we've been like honeymooners since he got back. I'm about 2 dpo now and already an decaf in anticipation!

Fx for that poppy! I am feeling more positive about things now- I really think taking the progesterone earlier made me feel terrible! As soon as I stopped it, I lost 3 lbs, so must have been bloated and I have read about it affecting your mood. This month I am due to get progesterone levels checked, so won't take it and will see what the difference is! Starting acupuncture again tomorrow as well.

Well done with the decaf poppy! No one can say you guys haven't tried your hardest this month!

Hope a BFP is coming up for you too Harriet! Must be nearly testing day- hope you're holding up ok!

When were you taking progesterone from starshine, and why? My treatment plan is only to take it from bfp I think.

I'm still only 8dpo today - time is really dragging! I took an extra day of pred yesterday but have stopped it today. I'll test on Sunday at 10dpo. I've had v faint positives at 10dpo in the past so hoping for that again, as I'm so worried now about having stopped the pred a little bit early.

I convinced myself I was pregnant earlier in the week as have been feeling tired, crampy and nauseous, but yesterday I felt way better. Think the tiredness is due to long hours at work and nausea is thanks to the pred! So now feeling demoralised again for no real reason!

It's so hard the guessing game isn't it every month! I have found on the pred I have no premenstral symptoms at all! Hope these next few days go quickly for you Harriet. Work still sound so crazy for you! Hope it calms down a bit!

Had to take the progesterone as mr s thinks there might be an issue with my luteal phase, but I am not really convinced and definitely want to know what my progesterone levels are before taking it again. Do have to take it when I get a bfp like you

We are on holiday in a week so now looking forward to that and focusing on that.
Hope everyone has a good Friday!

Hey guys

I used to be on this thread a very long time ago! I thought I would come back on to just say I'm finally 23 weeks after 6mc (up to 9 weeks) and 3fresh ivf cycle and 1 frozen cycle, lots of tears, and a hell of a lot of money later!

I never ever thought I would get here, and I still have a long way to go but getting to this stage is wonderful when I ha never thought it would happen.

This board was really helpful and supportive when people in real life just can't understand the pain.

I miscarried on shehata plan, then miscarried with argc, but finally gorgy at the fga London and pgs cycle at my local clinic got me here. I always felt like if I miscarried on immunes I was doomed. But turns out despite being 28 when I started ttc I was loosing chromosomal abnormal embies and I believe it was pgs which massively helped me as I got 3 normal embryos this last cycle one of which is now inside me :) obviously I did full immunes too so who knows wot exactly helped!

I don't have any medical issues but dh had low sperm count which dropped as we were trying to conceive due to previous surgery in the area. So we had some natural conceptions and each ivf cycle gave me a bfp too....

Good luck to all of u, it's a long and hard journey xxx

Thanks so much Tryingno1, for your lovely and encouraging update! It is exactly what's we've been needing;some feedback and a success story, cos many of us are really starting to feel like we are just crossing our fingers in the dark!

Chin up, everyone, this is such a hard journey but it's going to be worth it. I always think it's important to separate thought from fear; just cos we fear the worst does not mean we honestly think or know it.

I've spent this week with my DP's kids and their mates and I'm the only adult without kids. Was feeling so defective and sorry for myself last night then suddenly my little step daughter comes up and talks to me about "crazy walking" and gives me her little hand to hold on the way to dinner. Cheered me right up. My DP's sister in law is also here, 8 months pregnant with baby 3 and after 3 Mcs and she's been super constructive, telling me it's only a matter of time for me and DP.

Yes thanks tryingno1! We really did need to hear a success story! Thank you for sharing your experiences and updating us.

Poppy that sounds like a tough week! But good that you have some support too from your sister inlaw and how lovely of your little step daughter - she has no idea of the power of her 'crazy walking' chat and that simple hand hold from a little one. Are you post ovulation now poppy?

FW should be sometime next week for me. Must stop myself getting stressed about it! Hope you're doing ok Harriet and keeping your mind on other things until tomorrow!

Have a lovely weekend all

Wow starshine that's come around quickly - how long are your cycles? Fx for you this time!

poppy that's such a lovely story - what a little pet. Are you in the tww now?

Also great to hear from you trying - can't believe how much you've been through. Huge congrats on your pregnancy and thanks so much for sharing. How old are you, if you don't mind me asking?

I'm 9dpo today and have been feeling absolutely terrible, which im so hoping is a good sign but also worried it's just side effects from the pred. I'm exhausted, crampy and nauseous. Boobs not at all sore though despite a lot of prodding! I will test tomorrow I think.

Hi all,

I'm currently under treatment from Mr S after 3 mc's and had a BFP a couple of weeks ago ⭐️ Currently 4+5
I suffer from high Nk cells and very high sticky blood so have been on all the usual including Pred, Fragmin, cyclogest (progesterone pessaries) I tested for pregnancy on day 9 and test was negative so I stopped the pred for 5 days! Then I felt pregnant, 3 tests later - 3 BNP's and I'm a bit of a nervous mess as seem to have silent mc's at around 6w.
When I had my first intralipid, I met a few lovely ladies, one of which had 5/6 previous mc's and 1 beautiful 1 year old boy while under Mr S treatment, she was 5 weeks with her 2nd which was lovely to hear.

Harriet, since I went back on pred I've slowly been losing pregnancy symptoms which apparently can be a thing. It may be the reason your boobs aren't sore? Fingers crossed for you!

Anyone else have nk + antiphosphilipid?

Xx

Hi Harriet I'm 33 now but was 28 when ttc.
My only tested mc was no 6 and a chromosomal abnormamlity. But I suspect some of the others were too...I had frozen blasts at age 30 pgs tested and refrozen all 3 were abnormal despite being high grade...
My next fresh cycle gave me a totally diff result though!

29 when started ttc I mean

Welcome JustLa! Sorry to hear about your past heartbreak, but congrats on your BFP! I wish there was something I could say to help you stop worrying about the 6 w mark, but I know exactly what you''re going through and it's impossible not to worry. No reason why this won't be the rainbow one, especially given all your meds.

Starshine and Harriet, yes I'm 4 dpo and trying not to symptom spot. I am a bit crampy and cranky with constipation, increased cm and lower back pain. BUT I had a lot of symptoms last month too and was stunned when I got a BFN.

Starshine, I suppose they may test your progesterone next time you get a BFP. I had mine tested when I had bleeding at 4.5 weeks and actually it was 27, which is good and by HGC doubled to 7700, then I miscarried a week later and my HGC was 474 so I really have no idea about the progesterone effect. My sister in law got HGC injections and that seemed to help, but I have no idea what that involved.

Harriet, fingers crossed for POAS day, do let us know promptly! ;)

Morning all. Just tested and...BFN!

But I'm not willing to accept I'm out yet because I just feel so pregnant (so tired, nauseous, cramps, thirsty and weeing lots). Maybe I'm completely deluded! Today is 10dpo for me and AF isn't due until weds or thurs, so guess I'll keep testing over the next couple of days. What should I do about the pred though - wait for a bfp?

Welcome justla and congrats! I've just got NK cells that are a little high and very aggressive apparently, blood is ok.

That's the spirit, Harriet, 10dpo is still borderline if we are honest! Can't hurt to keep taking the Pred until you know either way, can it?

Fx Harriet! I agree with poppy- it is early- I would keep testing too and hopefully you are! Hope you're feeling ok about it all

Symptom spotting drives you nuts doesn't it poppy! Especially as the pred does seem to dull premenstral symptoms anyway- the number of times I googled things last cycle- well actually I think I google the same things every month 😀

My cycle is only 25-26 days Harriet- got my first flashy smile today at day 7 of my cycle- But this month we are not going full throttle straight away as last month I think we were both a bit worn out by the time we actually hit peak as normally ovulate day 13/14.

Have restarted acupuncture yesterday too- has anyone else done that?

Welcome justla! Congrats on the BFP! Really hope this one is a sticky one and mr s treatment plan works! Had you been on the steroids for many cycles before you fell?