Immune /natural killer cell treatment when ttc or pregnant (aka the 17th pred thread!)

[Hula2]

This is a thread for those diagnosed with high or very high natural killer cells and trying to concieve or are pregnant and taking steroids/intralipids etc

Newcomers very welcome

It's still so early drttc, don't rule yourself out this month. I stopped testing early because DH didn't want to stare at wee soaked sticks with me and wonder is it or isn't it.

I know what you mean about watching money fly out the window. My latest worry is that if its bad news on Wednesday its back to square one minus nearly all our savings.

trying how was this morning? I had an absolute nightmare on the trains again, I swear the stress of public transport is bad for you. When will you have results? Does that mean in January you can be all systems go?

Well it's Jan if my bloody tnf comes down!! Ow might be rven later!!! It depends on how quickly I get the results as I will need another humira round if I haven't responded. And then if still high intralipids and then u can cycle regardless. Really is testing my patience! And I'm the least patient person ever!!!

I know I won't know wot else I can do. I'm going to be seriously physchologically scarred and hopeless after the next round if it fails.... Pgd is only 95 percent accurate though so I suppose there's always a 5 percent?! Terrified of the waiting for then it to fail again. But aren't we all!

Hope u feeling better....are u going to test tmrw?

Waves to everyone.

Thanks Seeking. I wish I had the restraint but towards the lead up to 10dpo I always crack :-/ To top it off- do you drive yourself crazy symptom spotting? One hour I'll think 'I have no symptoms- and I'm on steroids anyways- so stop!' The next I'll think 'I sneezed twice- surely that's a sign!' It's driving me nuts... Completely understand what you mean about wanting more from the NHS. I did the same a few months ago (also not really knowing what I wanted). Was recommended to the fertility clinic but have yet to receive the referral... Also now waiting on hubbys sperm analysis. Will be hearing in a week.

Snoopy please don't think like that :( I know it's hard, and may be a protective mechanism, but that little bean is very snug in there!

Trying- 95% accurate sounds pretty promising tbh :)! On the patience front I feel like a lunatic... Patience level at 0!

Yep I'll test tomorrow... And the day after... And the day after that. Multiple times each day. Because I'm in the POAS addiction phase of my cycle :( Boo!

Sorry missed the last 2 posts.

Seeking my rmc clinic are v supportive. Are u in the system and have a good one? I never did but I'm sure I could have booked in for advice if I needed it....it was a book ursrlf when a bfp clinic for a chat and a scan....hope ur dh results come back ok. I'm sure they are fine.

Snoopy I took the bus from my sisters so I just sat and wasn't at all flustered. The tube in the am is too much to bear!!! all will be well for u on wed! U must stay positive :) ur young and had the tx and there's no reason at all for it to not be...but I would be a right mess if I were u so I don't know wot I'm saying really?!! Yep Jan is all go if tnf has dropped to normal levels. I'll start down Reg around Boxing Day and then stimms in Jan for egg collection mid Jan. However, if tnf hasn't dropped its another 6 week delay with humira.

Shall update u all by end of week when I should have results!

Ps seeking I keep saying ur little quote to myself everyday recently. Was very very simple but also true "There's no real reason it won't work". I have recently had these anxiety pangs where I'm terrified I'll still be here trying in ten years and nowhere further. Then my mind wanders everywhere into who could I ask to be a surrogate for me?!! Then I think of ur saying, and I think actually that's true-calm the hell down!!

Drttc I rem the feeling every month testing. Bfn and then the tears. Frustration paranoia worry fear anxiety thinking f if and drowning myself in some wine! It's so annoying. I don't even know why I used to do the sticks as I always without fail got a positive on day 15. Was just obsessional. I think we are all like this...it's so annoying! I used to be quite a chilled out lady! Anyways now obv I don't track at all which is possibly the only good thing with needing Ivf.

Drttc ur last post just made me crack up!!!

(I know that wasn't the intention!). I hope that bfp appears for u in the next few days. I don't think anyone would get one at 8dpo?! Is it even possible?!

Haha if I can at least laugh at myself it's makes this a bit easier! Once I got the absolute faintest of faint (not visible in most lights) positive in the evening of 8dpo. Wasn't sure but confirmed it on 9dpo... But as I don't temp I'm never really 100% on the exact day of ovulation so I may have really been 9dpo to start with. But that's why I have my 8dpo obsession!

i'm glad my little mantra is helping Trying, we know the reason, we have the treatment, we have fabulous medical care on our side... 'THERE'S NO REAL REASON IT WON'T WORK'! I have to remember that too sometimes.

Just remember though drttc that despite you getting an early bfp at 8dpo before, it doesn't mean you will again. And also remember those pregnancies haven't worked out. It's much more likely that it's just too early. Still holding out hope for you. Don't put too much pressure on yourself.

Thanks Seeking! I hope your cycle goes better than mine!

BFN today again. Properly fell into the depths of despair! 5 months of nothing. Next month is our last try for the year... And if we do get it, the time I usually lose it is perfectly placed between Xmas day and NYE. Which means we could potentially have the worst Christmas of our lives OR just a sad one. I sound so negative and I wish I wasn't thinking this way... But I suppose it's natural after staying so so positive the rest of the month. Going all the way down to surrey, paying thousands of pounds in total just for a shot at something. And still empty handed. I'll cheer up for next cycle... But for now, Woe is me :(

Sorry it was another bfn but again - it's only 9dpo! . Also rem your body has been through a lot with 3 chemicals and maybe just isn't ready? It's totally Norma for it to take up to a year for a pregnancy to happen (I know however that this line didn't help me and it turned out after 9 months we discovered what was going on). But it really isn't "normal" to get preg so quickly like you did and like a lot of us do. and hopefully ur uterus is being more selective and telling the bad embryos to go away! Ur still in normal conception time so don't worry ! Sure dh sperm will be fine so u can be reassured - when do u get those results back? Are u taking progesterone post ovulation???

Have u got an appt with mr s maybe in the new year to discuss what to do next? I suppose he would say SUper ovulation? Would u do that?

Try not to think too far into the future. Ur young and have time for this to work out. The waiting and the limbo is really hard and the money side and training it down makes things harder and obviously puts more pressure on ursrlf.

Let's hope 2016 is all of our years as I'm coming up to 2.5 years of this, and the waiting and hoping and constant thinking is just too much!

Oh drttc I'm sorry, but you know you're not out until af arrives. I just know that when it happens it's going to be the best little egg and it will have been worth the wait but I agree that five months sucks. Do try and remember though that is s perfectly normal timescale. I think I told you my sister in law took two years, absolutely nothing wrong.

Ah the anxiety is ramping up. I can't decide if I want tomorrow to hurry and get here or not. I really chose the wrong book to read at the moment as well. The female detective has just found out she's pregnant and doesn't want to be and the murder victim had had a secret baby that died at birth because of anencephaly. To top it off two women got in the lift today chattering away and patting her belly 'i found out two weeks, it's twins'

Thank you for being my voice of reason Trying! Such good points about how long it takes to conceive, how our history isn't the norm, and who knows... Maybe the treatment is just helping my body be selective. Yes I'm on progesterone from after ovulation as well.

I just don't know about super ovulation. I'm put off by the fact that it can take 5 months for it to work... We just don't have that kind of money to spend without more of a certainty! If we were to do and end up empty handed I'm not sure we'd have anything left for other treatment options. I may change my mind in the new year... Do we have successful SO in our currently pregnant group?

No booking with Dr S atm... Guess I'd see him in the new year. Feels like such a waste to go down just to be told what I already know.

It is all too much I agree. The overthinking is the worst. Trying to be stress free, yet prepared/well informed enough to take the best next steps. Please please please let 2016 be a rainbow year for us all x

Thanks Snoopy!

Yikes that really is not the best reading material atm! Perhaps a happy tv series or book should replace it in the mean time? Is your scan tomorrow with Dr S?

Drttc I didn't mention this before because I don't know about it buttttt

Oops posted too soon

So I've been a long time rm lurker on the miscarriage thread. Quenby uses progesterone post ovulation to make the lining more selective. However in some women it made it more/too selective so she took them off it if no bfp after 4 months. Then they got preg
Now I don't know wot mr s thinks about that. I don't know wot the evidence is and I didn't want to mention it before as there's so much conflicting evidence who knows!!!!
Plus they give it for Ivf always as we don't make endogenous progesterone given its a stimulated cycle and not a natural cycle and it doesn't stop any bfp! In fact I got one first Ivf go.

Suppose I'm saying if u wanted to look on the rm thread (i think the last few not the current one which is v quiet) or if u just want to talk to mr s about it. But I don't know much about it it's just something I read about women who have seen prof when by!

Rosa was so cycle 2
Sunny had a bfp on cycle 5 but mc and then got preg naturally when she wasn't trying!

My dh job ends in 2 weeks as we thought we would be in bloody London by now! But still have no idea. I'm hoping so hard my tnf is back tmrw as I've literally been unable to plan my life past one month in advance as haven't known tnf results, now don't know if it's gone down.
We have literally been living month to month waiting for the next piece of info! It's a common drama for all new Argc patients but it's so unsettling esp as I'm obsessive planner!

I've read about them using progesterone at Coventry to make the lining more selective but I know quenby does subscribe to the 'hyper fertility' theory whereas I don't think Dr S does. It's a shame that thread has gone so quiet, they've all migrated to Facebook and I've never had an account. Your on progesterone to improve your luteal phase though aren't you?

trying what time do you get your results? I really don't know how people manage ARGC but I think I get through things by being in complete denial.

The scans at 5pm tomorrow. I feel bad because I've started to let myself get slightly attached to the little jelly fish and DH has patted my belly a couple of times (I've pointed out he's just patting bloat and the jelly fish is actually much lower down) but I think he's allowed himself to really get attached this time.

I'm ringing them tmrw first thing!

It's natural to have scan anxiety. U would be unusual if u were not' and it's also normal to get attached that's why mc hurts so much. That bfp opens up all these hopes and dreams. But ur over the most scary parts and on tx and all will be fine with ur jellyfish! Hope tmrw comes quick for u X

Thanks for the info Trying! I've heard vague things mentioning the prog and selectivity- but never that Dr Q would take people off after 4 months! I was on it for short luteal phase but tbf I only had that one short cycle... Wasn't a typical occurrence. I don't think Dr S believes in that either. Maybe I'll lay off the prog next month. At least not use it directly after O and hold off a few days... Thanks for the food for thought! Your memory is stellar!

Good luck with your results tomorrow Trying! It'll be good news I'm sure :)

Snoopy- you should be attached to your lil jelly fish! Can't wait to hear your news tomorrow :) Exciting day!

That's interesting re the progesterone and Quenby stopping it if nothing after 4 months...

Fingers crossed you get your results tomorrow Trying. It must be hard living month to month. Not knowing when it's going to start. But you're in the best hands... What really is another month if at the end you get your little miracle. You'll get there lovely.

Snoopy - you'll be fine tomorrow. I know it! But I know it must be scary. And completely normal to get attached - you've been growing that little jellyfish for what probably already feels like a lifetime!! I hope after tomorrow you can begin to accept that you're finally there.

i know its so difficult with so much conflicting advice! thats why i never bothered to mention it before, but thought it might be helpful for you drtcc, seeking i know ur still in your usual window. either way don't worry, i keep thinking each day that passes is a day closer to me being with my little one and same for all us girls. (rather then when I'm in a pessimistic mood and thinking ANOTHER DAY WASTED ON SOMETHING ILL NEVER GET AND BE CHASHING FOREVER!)

thanks for ur kind messages will keep u posted, i bet they are not even back.

snoopy good luck!!!!!! :)

Thank you

I agree, the conflicting advice can be so distressing. And it's not just with our particular issues, I've seen it across the medical profession. I guess the suck it and see approach is the only way forward but it really does drain the pocket!

Drttc - sorry for the bfn they just suck whatever dpo, hoping its just too early for you.

Trying - keeping everything crossed for a lovely low tnf tomorrow. I m like you in needing to have everything planned so can emphathise that this uncertainly on when you can get going must be driving you mad.

Snoopy - hoping your little bean is doing a lovely happy dance for you tomorrow and everything comes back fine. It ll be a great milestone to get past and you deserve to let yourself get attached.

Seeking - how are you doing? are you in the tww ?

Waves to everyone else, Rosa must be due pretty soon.

I m 5dpo tomorrow so starting progesterone (hope it doesn t make my uterus anymore selective since it seems to have done a pretty good job of that by itself for the last 18mns !!).

Did an experiment tonight and peed on an 10mu hpt to see how much trigger would show up and barely visible (at 4dpo) so think was pretty likely that last months squinter at 10 dpo was prob a chemical. Lets hope it means something might be starting to work.....

Good luck tomorrow ladies, looking forward to some good news.

That's a great way to look at things Trying. Good luck today!!!

And looking forward to your news Snoopy!!

Thanks Hula. Sorry it was a chemical last month :( You seem to really have everything in place for this go... Fingers crossed for you Hun

BFN for me today! I'm actually feeling a lot better than I did yesterday. Part of my 'process' is giving myself one day to really mope/wallow and let it all out. Much better than bottling it all up! I expected the BFN this morning and was already planning our next cycle before testing. Am toying with SO but an just not sure. Does it come out to £500 including everything or are there other costs like meds? And yes, in case you were wondering, I'm drinking all the coffee and wine in the next few days... Poor meeeeee!