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Conception

When's the best time to get pregnant? Use our interactive ovulation calculator to work out when you're most fertile and most likely to conceive.

Clomid

137 replies

Jackster123 · 03/08/2015 14:24

Hi any new starters on clomid
I just started my first round of clomid 50mg (3-7) had my scan on day 12 , two mature follicles on right and small one on left.
Had no side effects from taking clomid,but ovulation was so painful that I could hardly walk.

Would love to hear from other people there experience on clomid ..

Been trying for 3 years,miscarriage last year at 4 months, I do ovulate but not enough to substation a pregnancy,hence the clomid .hubby is fine with his sperm.. Am levels are low as well

OP posts:
VixxFace · 07/08/2015 08:10

birchy sorry to hear af arrived but you can start second cycle of clomid?

For ivf they will use my eggs but stimulate them. Not sure of the whole process yet. Was trying to be positive and focus on clomid. If I can do 150 mg that gives some hope.

bananafish81 · 07/08/2015 09:00

Yep for IVF they do 'controlled hyperstimulation' of the ovaries. Basically where Clomid is a light(ish) tap to nudge the ovaries into producing follicles which you hopefully release on your own, with IVF the FSH injections give the ovaries a massive kick to produce (hopefully) lots of follicles. You're given a trigger shot, like I was on Wednesday, to get the eggs mature and ready to pop - except with IVF they get the eggs out of the follicles before you have a chance to release them.

My gynae said some women are Clomid resistant - but not responding to Clomid doesn't mean you won't have a good response to FSH stimulation.

Keeping fx that the Clomid does its thing in the mean time!

Happy to share my rollercoaster story - strap in though, it's a bit of a beast!

(Apols and waves to Vixx who's prob been bored to tears by the saga of my weirdo body on the ttc with pcos thread!)

X

Jackster123 · 07/08/2015 11:17

Vix ....I'm so sorry about your ovulation, have you had your amh levels done ( blood test) this can be done on any day of your cycle,nhs won't do it,but can have it done private...its gives you your over all fertility ..it tell you what your egg reserve are, weather they are low,worth giving that a go,

Banana.....that's a really good size follicle,weird how it's thinned your lining already,is there any thing they can do to thicken it,also strange that u have taken it from day 8-13, but all doctors are different...

I had my 21 day blood test today,so will find out next week if my progesterone levels are high,I have 2 more rounds of clomid left,if that fails the nite onto Ivf .....better plant my money tree and watch it grow

OP posts:
VixxFace · 07/08/2015 12:29

Banana waves back definitely not bored. It's good to hear other stories and get support!

Thanks for the info. Ivf is so complex.

birchygoo · 07/08/2015 12:35

Hi Vixx, this will be starting my first cycle of clomid - Dr has given me three cycles worth and then talking about doing a laproscopy.

I am on a steep learning curve - you are all so knowledgeable so thanks

bananafish81 · 07/08/2015 15:19

Hi ladies

Here’s the epic saga of my ovaries, this is a long one, so strap in! Apols for such a long post, but quite a lot has gone on….!

So, 5 years ago I came off the pill to go and get myself checked out, as I’d never had proper periods when not on the pill, so did wonder if something might not be quite working.

One nine-month long anovulatory cycle later, I have a private fertility workup where I’m diagnosed with PCOS, but everything else is looking dandy.

Dial forward 5 years and we’ve got married and want to start TTC. I’ll skip past the months of pre TTC planning cos of epilepsy and heavy duty pain meds for a spinal injury..

My gynae (private) had said we could start Clomid straight off the pill if we wanted, given that I’d basically never really had periods, so up to us if/when we wanted it.

In June I came off the pill just to have the summer to get one set of hormones out of my system before putting another lot in. Amazingly, I ovulated on my first month off the pill, and get a very light AF 2 weeks later. Which meant I could go and get my day 3 bloods done.

I saw my consultant last Monday for the results of my Day 3 bloods, and they were pretty much catastrophic.

When I’d last had bloods done, at the age of 28, my FSH was great (low), my AMH was good (high), my ovaries were polycystic but my antral follicle count was good and I had a cracking ovarian reserve. PCOS presents fertility issues, but it's usually very easily dealable-withable.

My blood tests last week indicated at 33 I had the ovaries of a premenopausal women in her late 40s. FSH ridiculously high (v bad), AMH practically non existent (very very bad). So bad that most clinics wouldn’t accept someone with those scores as the chances of getting any eggs out for IVF would be tiny. Seemingly crashing towards premature ovarian failure.

FUCK.

However the scan showed a different picture. There was def some activity going on in my ovaries, incl a dominant follicle, suggesting I was gearing up to ovulate this month. Whereas the blood tests suggested we’d see ovaries that were completely asleep.

In the consultant’s words ‘something doesn’t stack up’, as the tests are saying two completely different things, and all my meds over recent years might have sent my hormones haywire. So he starts me on low dose Clomid (50mg, 5 day course) to see if it has any effect at all on my ovaries - more as a diagnostic test than anything, as we obv didn’t expect anything to happen. So that’s why I had it from Day 8 - it was a bit of an unforeseen ‘oh shit let’s try and work out what’s going on’ decision, than a normal Clomid cycle.

The last week has been so so hard, as it was a lot to deal with. I’d gone from being polycystic with a good ovarian reserve at 28, to seemingly pre menopausal at 33.

I was coming to terms with the very real possibility I might never be able to conceive, and seriously thinking about the possibility of donor eggs. And very, very, very sad.

However.

Given the bloods, it looked like we’d need the sledgehammer approach to get any response, and the gentle nudge of low dose Clomid was likely to do bugger all.

Except it didn’t. I took it Mon-Fri last week, and on Tues the scan showed a nice ripe juicy 22mm follicle, and 2 other smaller ones that the Clomid had kicked into gear.

Fuck. Me.

Consultant said he absolutely didn’t expect to see this at ALL. He was flabbergasted looking at the ultrasound screen. It is v v v good news.

Holy crap, my ovaries responded to low dose Clomid. WTF?!

My lining was very thin, so even if we do manage to catch this egg, the chances of implantation this month are slim. And giving me medication to thicken the lining would throw everything else out, and he doesn’t want to bugger around with my messed up hormones even more.

Basically the lining hadn’t tracked with the follicles - and the Clomid also completely dried up my CM. And as he explained, there’s several parts to conceiving - getting an egg, getting it fertilised, and getting it implanted. Clomid’s helped with the first, but with hostile CM and a thin lining, that’s likely to make getting pregnant quite tricky.

Had a trigger shot on Weds, which means I should have ovulated today.

Which hopefully means I’ll have an actual cycle and even if I don’t get a proper period because the lining is so thin, my cycle will be reset so we can redo the Day 3 bloods.

Well, obv I hope I miraculously get a BFP in 2 weeks, but hey!

The Clomid response is v positive but the effect on the lining / CM isn’t great. He’d said in very lean women with low oestrogen anyway that can often be the case apparently Sad

And we still have the question of WTF is going on with my hormones. My bloods say one thing, my scans & ovaries say another.

My consultant is the lead clinician for reproductive medicine at Barts Hospital, so he knows his stuff. He said the bloods had him completely stumped and (his words) ‘I’m not usually stumped’.

So Christ knows what kind of medical freakshow marvel I am.

However, given I’ve miraculously responded to 50mg Clomid - which according to my blood tests shouldn’t have happened - then there is a v v v good chance that I should respond well to much stronger FSH stimulation for IVF

Head still spinning tbh!

PHEW

If you made it this far, have a Star from me and well earned Cake and Wine!

birchygoo · 07/08/2015 17:45

wow banana what a rollercoaster ride you have been on!! an amazing g story and fx for an even more amazing finish!!

VixxFace · 07/08/2015 18:15

Banana what a roller coaster! I am sure you don't know how to feel. The main thing is you had the big follicles that's what you want to see. My fingers, arms and toes and everything is crossed for you!

Moomin37 · 07/08/2015 19:40

Hey Banana thanks for sharing your story :) I am also lean and low estrogen - I have hypothalamic amenorrhea. I take my fifth Clomid tablet tonight... so far I've been rather hot at night and had slightly blurred vision.

It's great to have a small groups of lovely people to share the journey with Smile

Peardrops3 · 07/08/2015 20:17

Hi Ladies

mind if i join?
sorry not to hear of any BFPs yet but fingers crossed!!

So here's my story... we have been TTC for 2years now with no luck :( i have PCOS but DH is all ok...

so i started my first round of 50mg clomid this month D2-8 and surprisingly didn't have any side effects except a little moody on 7/8

so i had my first scan on Day 9 and i had 2 follicles at 8mm so they wanted me to come back today...so 2nd scan now and 1 follicle has grown to 11mm but clomid has thinned my lining to 4.9mm Sad so they want me back for another scan on Monday to see if any improvement... not feeling very hopeful and quite annoyed as before clomid lining was always healthy just was not ovulating...

anyone else experienced something similar? going a little mad searching google for answers Sad

Jackster123 · 07/08/2015 20:49

Hi peardrop,
Welcome to this thread,like you I never experienced any side effects,I've heard some horror stories....
Are u on your second round of clomid then, it's weird how clomid is meant to help us ovulate,but at the same time thins the lining of the womb...I'm on my first round my lining was 10 cm thick which is good,but who knows,hope Monday brings you luck let us know how it goes ????

OP posts:
Jackster123 · 08/08/2015 11:57

So had my 21 day blood test done yesterday at doctors,only to have a phone call later that day,saying we have thrown your blood sample away and won't be testing as you have gone private,the only reason I went private was my fertity doctor wouldn't help me and said try adoption,well you can guess I left there in tears...so had it done private today .( they were brilliant) ... Arghhh..... Doctors haven't got a clue what we go through mentally each month and wish they were more compassionate and understanding to us that are trying to conceive... And today I feel cramps like the witch is gonna arrive.....????????????????????????

OP posts:
birchygoo · 08/08/2015 14:57

OMG Jackster - I actually can't believe that, who ordered your d21 test? and did they suggest getting it done at your GP? That is shocking!

Was it the lab that threw it away? and the message just came back through your GP as why did GP take the blood then just to throw it away?

VixxFace · 08/08/2015 15:37

Jackster that's strange but good that you are at least getting follicles growing.

My womb lining went from 3mm to 10 mm in 6 days but NO follicles.

VixxFace · 08/08/2015 15:39

jackster that's terrible don't they realise how much of an up and down it is to just get the tests and not even the baby. What is your next step?

bananafish81 · 08/08/2015 16:00

Omg jackster I'm appalled. I'm fuming about how you've been treated - both what they did and how they handled it. I would def follow that up with the surgery to understand what was done by whom and why. Disgusting treatment!

Hi peardrop! Clomid is a bit of a double edged sword. As my consultant explained it, there's three parts to conceiving. Having an egg, getting it fertilised and the embryo implanting.

Clomid helps with the first one but in some - not all - women it can make the first two more difficult by drying up cervical mucus (so it's harder for the sperm to get to the egg) and thinning the lining (making it more difficult for a fertilised egg to implant). It's an oestrogen blocker which kicks production of FSH into gear - to hopefully stimulate follicle development - but as it's oestrogen that's responsible for the production of fertile CM and the lining thickening up in the run up to ovulate, in some women (like me) it can make us ovulate but make it more difficult to actually get pregnant Sad

He said supplementary oestrogen could be prescribed to help mitigate this, taken after the course of Clomid but before ovulation - so maybe ask your Dr if that's appropriate for you for your next cycle? X

birchygoo · 08/08/2015 21:37

just took my first clomid tablet! am quite frightened Confused dh is freaking about twins haha

birchygoo · 08/08/2015 21:37

oh can you drink alcohol on clomid - I'd love a wee drink now!

Bunnykins15 · 08/08/2015 22:17

Hi all, I am probably going to start clomid soon, it's helpful to read about all your experiences so far

bananafish I wonder if your recent bloods were actually not day 3 bloods after all - you say you had a light period after 2 weeks, perhaps if this was actually some sort of breakthrough bleed and you ended up having bloods around day 14 (two weeks after coming off the pill), coinciding with when you get the pre-ovulatory spike in FSH and LH? That could explain why your level was higher than expected for day 3. Not sure I can explain the AMH though.....

bananafish81 · 08/08/2015 23:17

birchygoo good luck! Don't seem to remember the packet saying anything about interaction between clomid and alcohol but I'm not a doctor or a pharmacist so I'd check the leaflet to be sure!

bunny welcome!!

Hope your journey on clomid is short and you get your bfp soon. Is your cycle being monitored?

Re: my weirdo bloods, it's a nice thought but the light bleed was 2 weeks after ovulation Sad. I had a positive OPK and ovulation pain and then my temperature rose the day after the positive OPK and stayed up for 14 days after which my very light AF came. Consultant reckoned that def sounded like a proper cycle but poss that thin lining meant I didn't have a proper bleed. Long term use of the pill can thin the lining....but what didn't quite add up was that my bleeds when on the pill, whilst still light, were heavier than my first natural period (5 weeks after my withdrawal bleed). The pill suppresses the building up of the lining, but didn't stack up that my bleed off the pill should have been lighter than when I was on it...

I was on a double dose of the pill because my epilepsy meds can interact with hormonal contraception, so consultant thinks could possibly be that the various medications have wreaked havoc and haven't yet regulated. Said PCOS doesn't just go away! Even though that seems exactly what looks like it's happened - seemingly along with loads of my eggs!!

So fuck knows what's been going on with my body tbh.

I know some recent studies showed that the pill did have an effect on AMH and antral follicle count - making ovaries look 'older' than they actually were, incl for several months after stopping the pill. I'm clinging on to the hope that my double packing the pills is what's made my ovaries look so geriatric!!!

birchygoo · 09/08/2015 23:06

how did everyone get on over the weekend?

I have now taken my 2nd clomid tablet. Im taking them at night time as I read somewhere that you are then more likely to sleep through any symptoms.

Peardrops3 · 10/08/2015 15:35

Hi Ladies

so iv had a awful weekend just crying at all silly opportunities... hope everyone elses is ok? i had to go to a wedding on sunday where everyone was showing off their new babies and as much as they are lovely i just felt awful and wanted to run away! its bad right? i know i should be happy for them its just so hard!

anyway so iv just had my 3rd scan and my lining has thickened from 4.9mm to 6.5mm and my largest follicles are only 10.1mm which doc is a little concerned about as they are growing but very very slowly i mean im day 14 today and still no sign of a egg! SO im booked in for another scan on thursday afternoon so fingers crossed one of these follicles grows!

@birchygoo - good luck with clomid and i took mine at night too for the same reason :) hopefully this round will lead to a bfp for you :)

x

VixxFace · 10/08/2015 15:45

Your womb lining is thickened so that's good.

Mine has thickened but no follicles. have to go back Friday again. They will discuss whether I should do self funded iui or 150 mg of clomid.

redannie118 · 10/08/2015 15:53

This reply has been withdrawn

The OP has privacy concerns, and so we've agreed to take this down now.

Peardrops3 · 10/08/2015 17:05

@VixxFace hope your follicles wake up on Friday to give you a surprise!

@redannie118 great story hopefully we can all have such positive stories to tell soon!

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