TTC Super Ovulation...

[duggs1976]

hey ladies,

There are a few of us who are ttc after mc's, however there will be ladies out there who are also ttc for the first time or second or third without success. If anyone is on, considering or had success on a super ovulation programme then do join us. How long did it take ? Did you try IUI with it.. ? Did you have PCOS?

Kicking this off and hoping some of you will join....

It is surprising Snoopy how many people find lumps and it turns out to be nothing. When I told my manager at work she had found one ad well that turned out to be nothing. I know it's really hard but you must try not to worry too much.

I have down regulated now and have been taking an oestrogen tablet to get my lining nice and thick. Have a scan next Thursday and then embryo transfer the following week. Seems to be taking for ever at the mo and time dragging. Have been feeling very tired and the drugs have turned my brain to mush as keep forgetting things at work!

I know somebody on here told me about what supplement they take fur being hetero mthfr but can't remember what it was. Also don't understand why Mr S didn't tell me to take something for this. He pretty much said just forget about it....

ovitrelle is the trigger injection to force you to ovulate..Gonal F is the follicle stimulating drug (instead of letrozole)

It is so strange that Dr S seems to be inconsistent with his suggestions. Do you think he likes to mix it up a bit to get more info built up .. ie patient A was on this and this happenend and patient B was on this and this happened..?

I am with you kittens I have been on pred 7 months.. and this last mc was with chromosonally normal eggs and I had 3 lots of intrallipids (usless and now 2 weeks later not used) and pred 40mg - again (seemingly useless) .. so thanks Lisa and scooter really useful.. I am not planning on staying on pred until I get a BFP.. and I am sure my lack of BFP was down to pred.
x

pebbles I'm homo MTHFR and I take 5mg l-methylfolate, which is the methylated form of folic acid. That plus a baby aspirin every day. I'm surprised that Mr S told you to forget about it; you have one working copy of the MTHFR gene, so you do metabolise folic acid (where those of us with two faulty copies of the gene don't), but you don't metabolise it as well as those who have two working copies. I know in the US a lot of ladies report having multiple miscarriages when the only thing 'wrong' with them was being hetero MTHFR, and went on to have successful pregnancies when treated with high dose folic acid, BA and in quite a few cases Lovenox.

kittens I too am with you with the thoughts on pred, which is why I will now only take it from BFP, if I ever get one again! As you know I am waiting with interest to see if my AFs return to normal within a month or two, and it was heartening to read on the pred thread that this is exactly what happened to sue when she stopped taking them.

Don't know about the Mr S thought duggs but that certainly sounds plausible to me, and exactly what scientists do, right? As with kittens I'm very surprised that his reactions differ from patient to patient when they report the same, or very similar, occurrences.

Thank you so much Ari for the info and explanation. Sorry to have been asking again but forgot as my brain has turned to mush!! Seems like I need to start taking that pronto and very weird Mr S didn't tell me to take anything for it. In fact am now panicking that I haven't been taking it earlier, best get googling!

It seems then that the pred is very hit and miss, as I have only had one cycle on it haven't been able to comment to much. Wish I could wave a magic wand and make things better for everyone on here as lots of you seem to be having a shitty time of it at the moment. :( I don't understand why Mr S isn't taking taking into account all the feedback you have been giving him as to the pred affecting your cycles, has defo affected mine even after only being on it for one month.

duggs thanks for the info on the Gonal f, might ask Dr S about it when I see him. Seriously thinking about having the hysteroscopy but i'll see what he says about my lining on Tuesday.

I remember thinking that the pred would be my saviour and that I'd get preg and it would all be great, that was in bloody November, its nearly May!!!

I know what you mean I was so enthusiastic at beginning (Nov was my first round too. ... Get pregnant. Take steroids. Ta dah baby! Feel stupidly naive now.

snoopy i'm starting to wonder if it will ever happen now, my GP has changed her tune and has told me at my age I don't have time to waste and should have private IVF

Hey Lisa and Snoopy I was thinking that to that it would sort out my problems but being on here has educated me to the fact that unfortunately doesn't work for everyone. :(

Ari can I ask where you buy it as after some googling only seem to be finding it on USA websites?

pebbles I usually shop around for the best price but as luck would have it I just bought my next lot 10 mins ago, and my latest best-price site is the Vitality Shop - www.vitalityshop.co.uk/search.php?search_query=Folapro&x=0&y=0

HTH

Thanks so much Ari really appreciate your help, will be buying some tomorrow.

Good morning all. Just to keep an eye on the SO stats. I have pulled this across. Obviously it needs to be updated but it would be nice to closely monitor peoples test dates and wish them well, etc. Feel free to update/add, etc.

Duggs pred 7 & SO 4
Pebbles pred 1 & SO 1
Snoopy pred 5 & SO 2
euro pred 5 & SO 3, now on IUI
Kittens Pred 10, starting SO3
(13 months overall on pred, but inc 2 month and 1 month break so far)
Abney SO2 - Waiting to test (from next Wed onwards). One large 24 mm follicle. Left ovary not considered to be functioning properly so I will increase drug taking next time if this time fails.

Suemays pred - 3 rounds then had a CP, 3 further SO then another CP in March (total of 6 months on preds). On 2 month wait.

Thanks Abney ...we need some SO successes on here too don't we.

umm... come on eggs get fertalised and bloody well stick.

Sue what is your next app with Dr S do you have one ?

Hi all, can I add myself to the list? Am now on day 4 of letrozole (and feel no different) have 2nd appt, scan and test results with Mr S next week. Lisa i'm thinking the same re the hysteroscopy, may well have it this depending on how the scan goes.

Duggs pred 7 & SO 4
Pebbles pred 1 & SO 1
Snoopy pred 5 & SO 2
euro pred 5 & SO 3, now on IUI
Kittens Pred 10, starting SO3
(13 months overall on pred, but inc 2 month and 1 month break so far)
Abney SO2 - Waiting to test (from next Wed onwards). One large 24 mm follicle. Left ovary not considered to be functioning properly so I will increase drug taking next time if this time fails.
Suemays pred - 3 rounds then had a CP, 3 further SO then another CP in March (total of 6 months on preds). On 2 month wait.
Carebear1 SO 1

carebear I've been in two minds about it but feel unless something comes up in my DH's SA next week then its really the only other thing to try before we end up down the IVF road

lisa have you had any other similar? I've had both hysterospinogram (spelling? the one with the dye in the tubes) and a laparoscopy (keyhole through the belly button) so i'm a bit non plussed about the differences and why a hysteroscopy would show something the others didn't but it might be worth a try

God what a miserable bloody day!
Just updated mine. It's nice to be able to see what's happening at a glance.

Duggs pred 7 & SO 4
Pebbles pred 1 & SO 1
Snoopy pred 7 & SO 2 (not doing SO this month) Testing 2nd/3rd May
euro pred 5 & SO 3, now on IUI
Kittens Pred 10, starting SO3
(13 months overall on pred, but inc 2 month and 1 month break so far)
Abney SO2 - Waiting to test (from next Wed onwards). One large 24 mm follicle. Left ovary not considered to be functioning properly so I will increase drug taking next time if this time fails.
Suemays pred - 3 rounds then had a CP, 3 further SO then another CP in March (total of 6 months on preds). On 2 month wait.
Carebear1 SO 1

Hello, just changed my details slightly.

I have had Hycosy/Hyfosy and am now on NHS waiting list for Hysteroscopy which was recommended after possible scarring showed up on Hyfosy. I believe that as well as going in for a look, if there are any scarring/damage/adhesion issues they are addressed with a laser there and then as part of the Hysteroscopy.

Duggs pred 7 & SO 4
Pebbles pred 1 & SO 1
Snoopy pred 7 & SO 2 (not doing SO this month) Testing 2nd/3rd May
euro pred 5 & SO 3, now on IUI
Kittens Pred 10, not ovulating on SO3, waiting for FSH test & changing treatment next cycle (13 months overall on pred, but inc 2 month and 1 month break so far)
Abney SO2 - Waiting to test (from next Wed onwards). One large 24 mm follicle. Left ovary not considered to be functioning properly so I will increase drug taking next time if this time fails.
Suemays pred - 3 rounds then had a CP, 3 further SO then another CP in March (total of 6 months on preds). On 2 month wait.
Carebear1 SO 1

Hi all, I think that the list shows that we are all relatively 'newbies' on the SO. As my AF's are usually really heavy I am keeping a close eye on things due to other peoples comments. If they get lighter then perhaps it is the SO itself that is causing issues as I have had no issues on Pred for the last 2 years. My AF's usually amount to palm size clots which often 'fall' on the floor. TMI I know. By the way more TMI the last 4 times I have got pg was due to SWI in the morning and I read that you are more likely to get pg by doing the 'deed' in the morning so come on girls wakey, wakey. .

Snoopy all the very best of luck this week. I will keep everything crossed for you.

Thanks abney your a sweetie. I don't think for a minute I'll find anything out on Tues though.

Took my first Hydroxy today! Here we go, new drug and more naive enthusiam. for any that might ask why I am taking it, it's because couple of months ago I couldn't stand the insomnia on pred any longer and looked like death after 4 days of 4hrs sleep each night. So Dr S said I could get the stop the pred and if I wanted to take the risk I could just take Hydroxy.

To be honest I feel sick in case this is anything sinister and am worried that all these drugs together don't agree with me or have awakened something that wasnt' there before. I was surprised that both Louise and my GP said carry on taking it?? As it's supressing my immune system?
So I am getting off the pred from OV from now, if no bfp next week. I will have to think if I ever got a bfp whether to take 40mg from bfp or risk it. One thing that concerns me about that is that back in Sept my Activation for NK cells was 3.16 so I would need to chuck everything at it...if it ever happened again.

carebear he thinks the problem is that I have scarring from 2 ERPC's and a perforated uterus and that is why my lining isn't great and why I have very light periods, the hysteroscopy will help tidy it up as so to speak. I have read that they sometime out in little cuts to help with implantation??

Abney I found it hell on the steroids and my periods have become lighter and shorter since being on pred and my cycles lengths have been all over the place. Dr S has agreed that I don't have to take the steroids until bfp. My nk cells were only 1.26 so i'm prepared to take the risk at this stage, was hoping he would give me hydroxy.

snoopy i can totally relate to the feeling like death, I just couldn't function on them, it made work hard to cope with

Morning ladies ... Any of you doing SO also using CBFM? If so, did you notice anything weird? CD6 for me today (so last day of Letrozole), monitor asked me for a stick (which is very early) which then showed a High! WTF? I only just finished AF! But I know that Letrozole inhibits oestrogen, and I wondered if it's anything to do with that? Will use trusty OPKs nearer the time I should ov (yes, I know Mr S will get me to do the trigger shot etc but monitoring as well just in case I ov early), which I know don't measure oestrogen.

Btw very little side effects with the Letrozole (5mg - or is it 5mcg?), hot at night but no spots and nothing else. Phew. :)

ari glad the Letrozole not causing any probs. I can't help with the monitor as I have never used one. does a high mean you are ovulating then? Bit early eh? when are you booked in for your follicle scan? (your not on our little list yet)

Terrible sleep last night. was awake from 3.30am till about 6 when DH alarm went off... aaarrgghhh! Managed to drp off for another hour until DS got up and had to drag myself out of bed. the one thing about pred is it fires you up and gets me out of the house but feel crossed eyed with lack of sleep and keep stumbling over speech. not good.

Argh snoopy, sorry to hear about the rubbish sleep. I really don't miss that, I have to say! No, a High means your LH is starting to rise in preparation for an eventual Peak, which is the same as an OPK smilie face, indicating that ovulation is due within 24-36 hours. It's just I've never, but never, had a High this early - my usual ovulation is around Cd13 to 14, it's usual to have 3 days of High before the Peak (as I got last month). I can only assume it's down to the Letrozole messing with my hormones, although I did find other ladies that say they use CBFM ok with Letrozole. Who knows, it's a complete mystery what's going on!

Ah, I'm not on the list 'cos I'm really not sure what to put myself down as! This would be my 7th month on pred, with one MC on the treatment, but I didn't take it from ov last month and won't again from ov this month. So not sure what I put for that! And only first month of SO, with my follicle scan on Sat 5th.