TTC Super Ovulation...

[duggs1976]

hey ladies,

There are a few of us who are ttc after mc's, however there will be ladies out there who are also ttc for the first time or second or third without success. If anyone is on, considering or had success on a super ovulation programme then do join us. How long did it take ? Did you try IUI with it.. ? Did you have PCOS?

Kicking this off and hoping some of you will join....

Sue I am sooooo sorry to hear it was a chemical. You must be feeling all over the pace emotionally you poor thing, thinking of you and you know we are here if you need a rant.

Snoopy sorry that you didn't get your bfp, hope you have got your letrezole so you can try again this month.

Kittens sorry can't be of much help with the anxiety attacks, I think the others have given the best advice re some deep breathing etc.

Euro please feel free to quiz me re ivf if I can be of any help or put your mind at rest. It really is ok once you get started, yes the emotions can be very up and down but I promise it is not as bad as you think. If it worked for you the process of how you got your bfp would soon be forgotten.

Jaffa glad to hear all ok with you so far, keep us posted. :)

Well I gave in and did a test today (11dpo) and of course was a bfn. Will do one more test Tuesday just to be sure and then stop the pred.
Have been discussing with my dh this morning if we should go back to ivf to use our frozen embies in conjunction with the steroids. It's so hard to know what to do for the best......

Does anyone really understand why the super ov treatment is more likely to succeed in month 4-6?

Hi to everyone else and hope you are having a good weekend.

I know what your saying duggs/pebbles. I don't know either but someone said somewhere that it improves egg quality? So maybe that's how it helps over time? Wish I could find some info on that too but been googling for an hr since duggs posted and can't find anything on that side of things.

Found Asda in Leamington Spa who has Letrozole in stock but can I find the bloody pescription!!! Got the Ovitrelle but not the other!! Have to keep searching else it's off for me this month.

Jaffa glad things going good for you. this was 5th try then? Well you persevered and got there in the end. Well done you. I need to muster up some patience!

Also been googling implantation problems and can't find anything that I don't know already - that I;m either not doing or as far as I know am not afflicted by iykwim. frustrating...........

I really want to find out about this cumulative success rate. It would help pebbles and euro at least. I can't imagine how making more follicles improves egg quality. Believe me I would like to believe that as I am sure that would help me.. But I'm searching. I guess we need more of us to get to 5th and 6th rounds on SO to see how true the claims are. pebbles I am inclined to think with your history IVF with steroid treatment is what u need. euro and kittens too. But all are personal decisions.
sue been thinking about your last 2 chemicals have they both been SO chemicals? What were trigger and test days is there a pattern?

I tried to post something earlier but Mumsnet was offline after I had spent ten mins writing something!
I was told letrozole improves egg quality but it takes a few months to work. Seeing as its mainly for women with old/low egg reserves that explains why it has a cumaltive effect. I am considering switching clinics to ARGC at the mo as I can't believe two chemicals in the space of three months is bad luck when all my others have got to 8 weeks. I am concerned my nkc have gone even higher as dr s said they get more aggressive with every pregnancy. I am already taking everything he can offer so what else can he do? The ARGC treat with other drugs and apparently have a higher success rate but are more expensive. I don't think even cgh with ivf would help me as the damn nkc attack everything. Any suggestions ladies as I feel like I am at the end of the road. My first cp was before I was on superov but this one was on round two. This cp had stronger preg tests and more preg symptoms but it didn't make any difference.
I am so angry as feel like I am wasting pregnancies as its a huge relief to get a bfp but what's the point if my stupid body kills it?

sue totally get where u r coming from. Now youve had 2 cp it does change the game. ARGC are the best and they have amazing success rates. I think perhaps an initial consultation might make you feel more positive as super ov is solving the bfp issue but that is pretty useless right now. Can u get an app this coming week?

Good luck hoe you can find your prescription Snoopy!!

I think you might be right Duggs although I feel I should give super ov a try.......will have to make my mind up soon before af arrives!

S it worth having another nkc test *Sue or have you pretty much made your mind up to switch to the Argc? What other drugs do they offer? It's so frustrating to get so close only to have it taken away again. Damn killer cells!!!!!!

sue this might seem like a silly question but are you sure this cp wasn't actually the ovitrille? I am sure you have already ruled that out.

I share your feelings, and I've also wondered about more aggressive treatment. I am sure that about 1/3 of the months I have been trying (most of them in the beginning but also on cycle 2 of superov) I have been sure that something is happening a few days past ov. I have cramps/a dragging feeling and feel a bit odd. And then about 8/9 dpo it always stops pretty abruptly. I think my body is attacking before I can even get a bfp.

I guess IVF might help me diagnostically. I can at least find out whether we can make good embryos. If we do and they don't take, then we can be pretty sure that it's an implantation problem (which is what I have thought from the start). But maybe an embie grown in a lab for a few days away from the nk cells will be more able to withstand an attack.

snoopy I'm glad you are halfway there. I know some drs advise starting Letrozole or Clomid a day or two later, so you could always check with Mr S whether you can start slightly late if you can't quite get it in time.

pebbles thanks for the reassurance. I've seen two close friends go through it so I know what the process is like (although they were both emotional wrecks throughout, it has to be said, and they are both normally level headed women). It's more the thought of it. And the concern that I am not 100% certain I would not view the child differently because it hadn't been obtained "fairly". The emotions I am feeling are quite irrational and I am aware of that, but they are what they are.

I am sure the ovitrelle was out of my system as the preg line got darker over a few days. Dh wants to try a few more months with dr s and then re evaluate. I am waiting for my hysteroscopy appt anyway so wouldn't be able to start ivf without that crossed off. Still don't know where we will go from here. Maybe i should have the amh test as have not had that done and it might give me more of an indication as to what is happening with my eggs.

sue I was sure you would have considered that.

I had the AMH test with Dr S, but I think it was a bit pointless. Mine was 12.something, so in the upper range of "low fertility" but Mr S just dismissed it and says he never sees the higher numbers. And my FSH was good for age. In short, I'm not really sure what it indicated.

Morning hope it's a lovely sunny day where you all are. It's gorgeous here.

found Letrozole perscription in DH fleece pocket from 3 weeks ago! phew. Good news is went to Boots in the end and it was £6.30!! Amazing cheaper than nhs perscription. So geared up to start that tomorrow. It all seems to come around so quickly this bit.

duggs my chemical was in Jan which was not on SO. And also got a line in Feb which didn't last more than a day or so which was on SO. So no pattern there. Even this month and inc today I still feel queasy a bit. My body is definitley trying very hard to get pregnant each month. I had every symptom this month and was convinced it was looking good.

When I go for my day 9 scan I am going to ask a few more questions re chemicals sue. So see what his opinion is on it. Get my monies worth this time!

1. what exactly is the success rate/on what cycle most popular etc?
2. Why does he think this keeps happening when nothing else appears to be wrong - (that's without having a hyster thingy to be sure) But surely if there was anything in womb like scarring etc or PCOS or the like he would have seen that on our Internal scan when checking for follicles?
3. How does Letrozole improve the quality of the eggs?
4. (from the other thread)...Would a hidden infection lie dormant for years even if with same partner for years and had child since?

Right I'm on a mission now! Anything else to add to this please do and I'll try and bring it up.

sue btw are you on Hydroxy now? along with pred? If so how is it?
I have just about had it with pred (sleep wise) and am going to ask if theres an alternative.

Snoopy I am on hydroxy but only been taking it for about 3 weeks. It takes 6 weeks to take effect on the immune system so he will probably keep me on it. He will ask you to stop TTC if you are not taking the preds whilst waiting for the hydroxy to kick in as you will miscarry without anything. Maybe you can do the same as me and take both?

I havent noticed any side effects on it. The preds are driving me mad too - I have such bad bags under my eyes as I am waking up 3 or 4 times during the night and then cant get back to sleep. Glad I am off them now!

If you get to see Dr S before me, can you ask him if many of his patients have had chemicals on his plan and then gone on to have a successful pregnancy?

Do we class chemicals as a miscarriage by the way? Is it more likely to be a killer cell problem or a bad egg problem with a chemical?

Also if we dont take the trigger shot will the ovaries only release one dominant egg or more (after taking letrozole that month)?

What level of letrozole are you on by the way? I am supposed to be going up to 7.5 if I am going straight back to super ov.

Forgot to say, apparently Superdrug now do all private prescriptions at cost price too.

Euro have you checked the other thread about hidden infections as this can be a reason why you are not falling pregnant?

www.fertilityfriends.co.uk/forum/index.php?topic=242395.0

There is also lots of info on here about how letrozole can help with implantation and other reasons why we might be having our probs. I was reading this last night at 2am as couldnt get to sleep!

Also found this on the same site:
www.fertilityfriends.co.uk/forum/index.php?topic=260560.0

Just spoken to Louise and she said lots of their patients have chemicals and then go on to have successful pregnancies so that makes me feel more reassured. She also said she thought there was no reason why I need to have IVF with CGH as have a daughter already who has no chromosome problems. Saying that, she said they have just had 2 ladies who miscarried and that was done to chromosome problems. DH and I have said that if we are still no further by August we will look at IVF so I do have a plan in place. Louise did say that IVF works best with the immune plan in place. I feel like at least it is narrowed down if a viable embryo is put back in where they have checked for chromosome probs.

I am wondering if this chemical might be due to the fact that I think my DD has just got chickenpox. I am taking her to the docs this morning as she has spots and flu like symptoms. Weird thing is, I have the flu symptoms which started around the same time as the preg symptoms subsided. Louise said my GP can do a blood test to see if I am immune which might explain my chemical.

I have been told to wait 2 cycles (one more period after the chemical starts) before trying again. Louise said I am more likely to miscarry again if I keep trying as my body needs a rest. Phew so no more steroids for 2 months. I am quite glad to be honest! I still have to take the hydroxy, vits and aspirin. So that means by around end of April/May I should be able to start again on superov. Think I will try and lose some weight and get fit again.

Right who is testing next?

Hi sue, sorry to hear about your chemical. I've only really been lurking recently. I just commented on the other thread about Array CGH.

I am 11dpo today and AF due imminently. Did a test this morning and was negative. Early, I know, but I OV'd on CD16 and have a 25/26 day cycle usually. I don't feel in the least bit pregnant anyway. Under any other circumstances I would wonder if I may be due to the very extreme emotional state I am in suddenly over the last couple of weeks but the cocktail of Super Ovulation, HRT (for my womb lining), steroids, grief and PMT are a rather explosive combination. I could well do without being on this treatment right now. I only wish I could afford to take some time out of TTC!

that's reassuring sue. Had all the Chromosone tests so that shouldn't be causing me any problems. good that you can have a break from all this for a while...and get of the pred!! I bet you come back with renewed positivity and feeling physically much better and anything that puts your body in a better state has got to be helpful to the cause.

kittens sorry it's a no so far keep testing. I can sympathise with you. I just don't have time to take time out of this, it would be nice. Desparatley want to go away at Easter and the time which is convenient and cheaper falls smack bang in line with having bloody follicle scan. I don't want to stop the SO now though if the Letrozole has more chance of being successful month on month...apparently.

pebbles is also testing so hopefully some more good news on here.

Hey ladies just wanted to add I also had chromosome tests karotyping and DH and we don't have genetic problem but over 60% of a 38 yr olds eggs will be aneploid (incompetent) so CGH is just a check on which embryo to put back. It isn't linked to the genetic issues that is PGD. Dr sher or Dagan wells. Sometimes they don't encourage it for older women as they need to take whatever egg works and can't afford to be too picky so to speak. Anyway I'm a guinea pig so will let u know. Dr s also said I didn't need IVF and CGH but here I am 3 yrs ttc and 7 mths on his programme so unless he can give another reason for my lack of success I'm going for it with the immunology programme. Wil keep u posted.

Yes duggs keep us up to date with how your getting on.

sue I'm on 5mg Letrozole at moment. produced 2 decent follicles first time so he seemed happy with that. See what this month brings. I am definitely going to see if I can get on the hydroxy alongside pred until I can drop pred if allowed. Don't know whether Louise can authorise that? Might ring her. At the moment can't get a cd9 follicle scan as he's in Harley st and it costs too much for me to go up there. And tues he's on NHS patients at Epsom!! great. Cheryl is trying to speak with him tomorrow to squeeze me in. If not spose I 'll have to find private sonographer round here.

Hi jaffa have you had your first scan yet?

Hi all, hope everyone feeling ok today. I was really miserable yesterday so think pmt has kicked in and still spotting and crampy but no af yet. Feels a bit of a waste to test tomorrow but I guess I best had just in case of an extremely rare chance it is positive.!

Euro everybodys obviously different and hope you come to a decision soon of what feels like the best path for you and your dh. If only we weren't faced with these kind of decisions.....

Snoopywill be interested to hear the answer to your questions. You are sounding very enthusiastic which we need on here at the mo! :)

Sue glad to hear you sounding much brighter and more positive with your plan in place. Make the most of your two months off and do the things you feel you can't do when ttc. Thanks for the links will be having a read if those later.

Kittens sorry about the bfn, are you going to test again in a coupe of days to be sure?

I still have been sleeping fine on the pred although the odd bit of anxiousness. Does the sleeping thing come along when you ave been asking it for longer?

I think my dh and I have decided to go back down the ivf route with our frozen embryos. Duggs when do you start taking the pred from when doing your ivf cycle?

pebbles, I think it affects everyone a bit differently. I have been taking it for almost a year on and off and haven't had any insomnia at all but like you I do feel quite 'edgy' on it. In answer to your other question, yes I will test again. I have been crampy since Friday but no AF yet. I am usually due around CD26 which was yesterday but I've been on the Cyclogest since mid cycle so wonder if that's delayed things a bit.

snoopy, isn't there someone else at New Life who can do a follicle tracking scan for you and then pass over the details to Mr S? When I had my HYCOSY scan done down there it wasn't with Mr S but he got the relevant data. Transversely, I find it a pain to get to NLC so last time I had my follicle tracking scan with an associate of Mr S at another Harley St clinic as he wasn't at Harley St when I needed to see him. The details were passed on, he made the follow up call the same day and I was invoiced through The Miscarriage Clinic.

pebbles is 10 days before embryo transfer. Am seeing dr s on wed for full IVF pred consultation but that's what I've been told by L

The cyclogest can delay things Kittens, I was taking it when I had my chemical a couple of years ago and didn't have any bleeding do didn't know anything was wrong until I had a 6 wk scan.

Thanks for the info Duggs sounds like I need to contact Louise asap ad if we do the ivf am going to try for a natural frozen cycle. Thus means they work with your natural ovulation and then pop the embryos back just after. Didn't manage it last time as missed ov so had to do it the drug way and down regulate first.

The cyclogest can delay things Kittens, I was taking it when I had my chemical a couple of years ago and didn't have any bleeding do didn't know anything was wrong until I had a 6 wk scan.

Thanks for the info Duggs sounds like I need to contact Louise asap ad if we do the ivf am going to try for a natural frozen cycle. Thus means they work with your natural ovulation and then pop the embryos back just after. Didn't manage it last time as missed ov so had to do it the drug way and down regulate first.

Whoops sorry for posting that twice!!