Yes, but it's as rare as hens bollocks.
A woman in my village used to be the dutiful little Christian wife, with 4 children with 9 years between them, stay at home mum for a decade (she was about 33,) and a lovely home all neat and pristine. Attended Church 1-2 times a week, and was a really softly spoken gentle woman.
I was gobsmacked to hear that she had run off with her friend/neighbour's husband, cleaned out the family savings of £50K, and left for Ireland, leaving all 4 children behind. The sort of thing you see on Channel 5 films and documentaries, rarely happens in real life. (IME.)
This was 7 years ago, she has never been seen since, and her husband and his mother are raising the children. He has not remarried.
Also over the years I have known 4 or 5 women walk out on the husband and school age children - sometimes for another man, sometimes just left to be on her own.
I know way WAY more men who have left over the years though. But yeah, women do it occasionally. Leave the kids and never look back. Could never do it myself; leave my children...