To think it will be revealed WLI cause physical aging

[Tuliptana]

Obviously the pictures of Kelly Osbourne are both sad and terrifying.

But a few women i know have also used this method for weight loss and their skin has lost elasticity. They look at least 10 years older. Is this side effect being under played?

Also this idea that incredibly wealthy famous individuals who live in the USA with completely different healthcare arrangements is comparable to the uk. Yes , people lie to get the injections. The pharmacies try to put measures in place to prevent it but if people are determined they can get them. That's on them. People also buy the fake ones from facebook. Again, nothing to do with legitimate prescriptions. I'm not sure why I'm meant to care about it. People have abused most drugs. That's nothing to do with people who take it in line with prescribing rules.

@Mrsredlipstick latest research on collagen shows it improves skin moisture levels and elasticity but won’t improve wrinkles per se.

I agree OP but Kelly isn't a great example as there is more going on with her.
Personally I wouldn't go near these drugs.

And that's fine. They aren't compulsory. But your preferences and assumptions don't make any difference to the evidence that being a healthy weight and on wlis is less risky than being obese.

I’ve lost 6 stone, I look fantastic. I used a decent face cream & collagen supplements. I look like an average mid-50s woman. I would sooner than than be dead from an obesity related illness.

Kelly .. my guess is she has an underlying ED that has been exacerbated by her current circumstances, I hope she has good people around her.

The increased use pancreatic cancer risk is already being noted. That alone is enough to make me never touch them - any increased risk of that deadly, horrendous disease is not worth it.

I think this is true, I’ve lost a few stone in the last year - still got BMI of 30 though, physically I look better, facially, look ok but def got more lines- however the osbornes have clearly gone way too far , it’s not just wli though, it’s surgery etc

Losing weight rapidly will make one look older, the method isn't the main reason here.

Indeed.

The points about insufficient long term data are almost invariably missing the context they need in order to make them worth taking seriously. Imho it's ok to think data since the 00s is too risky, but that also has to be balanced against the known, ongoing risk of obesity and the reality that nothing has been shown to work on a population level other than WLIs. Too many posters show no evidence that they're aware of this.

It's a problem a lot of critics and caution urgers over WLIs seem to have. Comparing it to the ideal, rather than accepting that the actual choice is between multiple non ideal options. It's the same with points about monitoring. They sounds reasonable enough on first listen, but there's no acknowledgment that the NHS clearly is not going to do any better and indeed already relies on a looooot of self reported data from patients that isn't checked.

I'd rather be slim and old-looking, than morbidly obese and dead.

Obesity is a risk factor for pancreatic cancer. Can you point me towards the evidence that weight loss injections increase it as every study I've checked doesn't show that

@inmyfashion no there isn’t. https://pubmed.ncbi.nlm.nih.gov/38175642/

There is a very small increase in the incidence of pancreatitis and you could hypothesise that that could increase the risk of pancreatic cancer. However, acute pancreatitis there is no definitive link but chronic pancreatitis is thought to increase the risk by 2-3 times.

Risk factors for pancreatic cancer we absolutely know about are diabetes and obesity. Glp1s have had long term use in the diabetic group and causes and causality could be misinterpreted here. Diabetes and obesity is the link to pancreatic cancer not the medication. We also know that diets high in red meat and smoking increase the risk of pancreatic cancer. Obesity levels and poor diet have been on the rise for a long time, which could very much account for the rise in pancreatic cancers.

There is more research needed into the causes of more younger women getting pancreatic cancers. These have been increasing for years and there is no link to glp1s as their prevalence would not show in data sets as yet. But the global increase in cases is due mainly to aging populations, obesity, diabetes and smoking.

Revealed?
It's one of the "symptoms".
This stuff is harsh.
The first poster said "better to look couple of years older, than be obese".
How about being both slim and aging reasonably?

Weight loss itself tends to be aging. I'm mid 40s. I've been using wegovy since early January and have lost a stone, which is about a third of what I aim to lose. It's shown more in my face than anywhere else so far and I definitely do look older- but looking older is not a terrible thing. I am getting older, it would be insane to think I won't visibly age. I could stay overweight and choose a chubbier and slightly younger looking face over a body that is a healthy weight and can move more and has a lower chance of all the health issues that come with obesity but that seems crazy.

Wegovy for me has not only meant I find it easy to eat fewer calories than I use, but also that I don't think about alcohol and I vape less. I will take looking a bit older over staying unhealthily overweight and drinking most nights and vaping like a chimney!

Probably been said already but KO has always denied using WLI. She said she had a gastric band a few years ago. It looks as if she's got an eating disorder.

I don't know enough details about WLI specifically but it's always been a risk of losing weight quickly that your skin won't spring back as you'd like. And I'd imagine younger women with more skin elasticity are less likely to be on the injections, partly because they're less likely to need or qualify for them and partly because they're less likely to be able to afford them.

There is no current evidence that WLI cause pancreatic cancer in humans. Stop speading misinformation.

You might do if your dad has been seriously ill and then dies. It's more likely she's developed an eating disorder, triggered by grief but compounded by the gastric sleeve.

Just adding - the drugs at these doses have been used by diabetics for anything up to 20 years depending on which one. I think if there were aging effects, it would have been noted within that cohort.

From research, it actually seems to do the opposite, with protection against certain cancers, heart disease (in addition to/separate from the improvement of weight-loss itself on these illnesses) and even dementia risk is thought to be lowered in some early studies. Am hoping the latter is proven to be the case.

Was about to post the same.

Obesity, however....

Hold on, you're surprised that between the ages of 53 and 60, she has become less muscley? No shit!

Given she is also type 2, she needs to balance that out with the need for the meds, one would assume she would rather manage her diabetes yes?

My OH is on the same meds, has been for nearly 20 years (same type, not necessarily the same one all that time). But he has also obviously aged in 20 years and his appetite has lessened naturally anyway as it does when you get older for most people (have to caveat everything on this site), he has also lost muscle, you can see it. He's managing his diabetes though.

Interestingly I got chatting to a fantastically interesting 86 year old on the bus the other day - extremely slim, swims, gym every other day , walks up hills- she was skinny yes, but actually looked incredibly well, even with a lot of lines, she’s an ex marathon runner . Whilst I’m not naturally her build I really admired her and she she admits she works at it and still eats well but carefully. Would she look better facially with a couple of stone on her, probably yes, would she be as fit and well physically, ? Probably not .

My private provider wouldn't let me jump from 0.5 to 1mg this month by the way, as my weight loss on 0.25 and then 0.5 has been significant and I have reported some nausea and tiredness. They said I could go back down to 0.25 or stick at 0.5. They share records with my GP. They aren't just throwing WLIs at anyone who wants them and they do seem to be using the data I give them to actually make considered decisions as to what they are willing to prescribe me, rather than just accepting my money and letting me have what I want. I know that's reliant on me actually being honest with them, but it does offer some reassurance doesn't it?

I disagree.
KO looks like she has a great number of health issues.

Whenever I've lost weight, on any kind of diet or regime, I've always joked that I lose weight from the top of my body down. Face is affected first, then droopy boobs (thank goodness they're not on show so OP and others can't comment on how 'awful' and 'ageing' they look!), then arms, then bum and legs. I've been doing exercise and weights which have helped develop more tone, and prevent muscle loss, but there's not many ways of building up muscle in my face - except by eating a really great diet full of healthy crunchy veg and nuts, rather than soft over-processed food.

I do know that if I drink too much alcohol my face fills up again - but that is certainly not the way I plan to go to appease the OP's concerns.