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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

To think it will be revealed WLI cause physical aging

830 replies

Tuliptana · 02/03/2026 07:14

Obviously the pictures of Kelly Osbourne are both sad and terrifying.

But a few women i know have also used this method for weight loss and their skin has lost elasticity. They look at least 10 years older. Is this side effect being under played?

OP posts:
Thread gallery
18
PurpleCoo · 02/03/2026 09:21

@BerryTwister starting to look a little lean and defined, not lean and defined by a long shot lol. But only need to lose 2-3kg, and then I will be titrating down and coming off for sure. I still have an overweight BMI, so definitely not taking things too far like some do.

MrsElijahMikaelson1 · 02/03/2026 09:22

A big issue here is people taking WLI when they actually aren’t obese in the first place but just want to lose a bit of weight easily. They don’t have the level of fat for WLI so the body in essence loses muscle as well as damaging the pancreas, which is important in insulin production. Misusing drugs is an issue

fartoomuchtoblerone · 02/03/2026 09:23

Maybe if women stopped bitching and gossiping about other women’s appearance we would all feel less pressure to look a certain way.

AmandaBrotzman · 02/03/2026 09:24

Imdunfer · 02/03/2026 09:20

At that point in time, the user needs to accept that they are entering a drug trial with entirely unknown long term consequences.

Do you think we aren't aware of that? Why do people like you think WLI users are stupid?

MonsteraDeliciosa · 02/03/2026 09:25

Calliopespa · 02/03/2026 09:13

Personally I think as you get older people look better with a little bit of weight on but everyone is different.

I agree with this - and I believe there is also quite a bit of evidence that, as well as looking better, it is in fact healthier to fall in the overweight (though not obese) category after a certain age.

But you will get hounded to death on here OP for criticising WLI weight loss: lots of posters get properly wound up if anyone so much as raises a question about them.

But you will get hounded to death on here OP for criticising WLI weight loss: lots of posters get properly wound up if anyone so much as raises a question about them

OP is getting hounded for her ignorance, untrue assertions - like internal organ damage - and inability to distinguish between misuse and correct use of WLI, not for mere "criticism".

I, like many used WLI as advised and lost 3 stone. My blood pressure is back to normal, my joints no longer hurt and I feel so well and healthy. I climbed a mountain last summer that I usually gaze at from my holiday balcony!
Do I look older? Not sure, but I certainly look and feel much better and am no longer feeling the consequences of obesity. I'm likely to live longer now, too. So WLIs have done the opposite of ageing me.

TorturedParentsDepartment · 02/03/2026 09:25

You deflate a balloon, it never pings back to its original state... you have extra weight for many years - all the collagen in the world is going to struggle to ping back your skin to that of a lithe 20 something. That's weight loss in general - not the injections.

I was 24 stone, nearly 25 stone. I was between a size 28 and 30 and at the point where there was so much of me that my mobility was seriously being hammered - which hits the point where your mobility is so impaired that your ability to move enough to lose any weight and regain mobility is impaired and you start to spiral.

I lost 6 1/2 stone on Mounjaro on as low a dose as I could get away with - over the course of about a year and a half. My face does look "gaunt" in comparison to old photos of me now - but in reality it doesn't - it's just completely changed my appearance as I've gone down to one chin. Yes my neck's a little bit saggy - not much, and I'm late 40s so things sag a bit anyway if you've lived in your skin - I went through a period just before Xmas where I did have horrendous neck sag, but I then hit a bit of a weight loss plateau where I think my body readjusted and my skin caught up a bit, had some minor hair thinning (again a feature with any significant weight loss) which has since resolved (my hairdresser doesn't pull punches with brutal honesty - again this is all stuff which happens when you lose weight when you're a bit older.

For me I've lost to the point my mobility's returned and I can do things like get to the gym and start lifting weights as I'm very conscious I'll have had a lot of muscle loss which will impact going on into older life. Yes I've dropped dress sizes (down to just above an 18) - my goal is only to get to a 12/14 type level - none of this "my neighbour took it and she's a size 6 now" nonsense - and the odds are I'm going to end up on some form of maintenance dose longer term - so what?

Yep there's side effects, there are side effects from everything - I've got long term auto immune problems from the covid-jabs. Not some kind of govt/pharma conspiracy - just sometimes people react in atypical ways to anything you add into your body.

The Osbornes are not typical of WLI users. They have issues beyond that.

Imdunfer · 02/03/2026 09:27

AmandaBrotzman · 02/03/2026 09:24

Do you think we aren't aware of that? Why do people like you think WLI users are stupid?

There is a poster above who says there are millions of patient years of data, as if she thinks that's enough. People are buying the scam patches being advertised on the Internet showing impossible weight loss. Yes, I believe some people will not be aware that there is no long term data on GLPs.

Why do people on GLPs keep getting so defensive?

naemates · 02/03/2026 09:28

MsGreying · 02/03/2026 09:17

One wli lady I know is moving into collagen drinks. I assume they feel old.
This one is dressing like their teen daughter and they're going out like twins. I can't imagine anything worse for the teen but I guess it makes you feel old and look old if you're comparing yourself to a teen

Nasty post

MonsteraDeliciosa · 02/03/2026 09:29

As a side note I'm not sure why people are wanging on about KO's extreme "suffering".

She lost an elderly father who'd been ill for some time. Probably describes half the posters on this thread, including me.

Ouuuuccchhhh · 02/03/2026 09:29

I think it’s well known that Kelly Osbourne has had that buccal fat removal thing to make her face more gaunt, she always had an issue with her jawline. That on top of WLI has led to her current state. I know she’s grieving too but I do think it’s the WLIs plus her gastric band.

I’ve been on mounjaro for just over 8 months and I’ve lost 3 stone 8 pounds, I’ve 6 pounds to go. Thankfully my face has remained okay but I do know a couple of people (younger than me, in their 30s), whose faces have aged terribly on it. They lost more weight than me though.

Whilst I feel amazing having lost the weight and definitely more youthful, I’ve found the mounjaro itself quite a brutal experience. I’ve had side effects and can’t go beyond 7.5mg or I feel terrible. This will be my last pen and I hope never to go back on to it again what with the lifestyle changes I’ve made.

DarkForces · 02/03/2026 09:31

Imdunfer · 02/03/2026 09:27

There is a poster above who says there are millions of patient years of data, as if she thinks that's enough. People are buying the scam patches being advertised on the Internet showing impossible weight loss. Yes, I believe some people will not be aware that there is no long term data on GLPs.

Why do people on GLPs keep getting so defensive?

Edited

Ummm. I've been told I look like I've got hiv, am too stupid to make decisions about my health alongside a qualified professional and am probably dying inside. It makes you a little fed up tbh

Thehop · 02/03/2026 09:32

It's not the injections that accelerate ageing it's rapid weight loss

I had a sleeve in June and have lost 150lbs. My face has dropped as has my body. I expected it and it's still better than being so big I pretty much rendered myself disabled.

MonsteraDeliciosa · 02/03/2026 09:33

Why do people on GLPs keep getting so defensive?

I'm guessing because they keep being attacked; usually with incorrect assumptions and downright wrong assertions.

AgnesMcDoo · 02/03/2026 09:38

Oh goody.

we haven’t had an anti WLI scaremongering thread for at least 10 minutes.

so relieved you posted this @Tuliptana😳

Hobnobswantshernameback · 02/03/2026 09:39

What @AgnesMcDoo ssid
with bells on

Rosecoffeecup · 02/03/2026 09:39

You will never convince me that the faux concern over people (lets be honest, mostly women) using WLIs is anything other than jealousy and bitterness that there is now an accessible, effective aid for us fatties.

I will quite happily look older in return for being much healthier

HeadDeskHeadDesk · 02/03/2026 09:41

gostickyourheadinapig · 02/03/2026 08:51

Nobody ever died of looking a bit older, but many have died from complications of obesity.

Yes exactly. I've lost just over 5 stone now and as I am quite short, that's a lot. I lost the first stone by myself then I struggled to go further and started yo-yoing, so I went on the WLI. It's been slow and steady with lots of months with little or no loss. I've been on WLIs for 2 years and 2 months now.

I am starting to get a bit pissed off with people prying about when I am 'going to stop.' and making comments along the lines of 'be careful you don't go too far. Think of your face.' and 'you look tired.' So what? It's none of your business and I don't give a fuck. I'm healthier and LESS TIRED than I've been in many years. My face isn't bloated and my double chin has gone. I don't wheeze and get out of breath doing normal things. I can walk further and run if I need to. I can bend properly to do my laces up. I have more energy. My balance is better. My knees and back and hips don't creak and ache all the time. My gastric reflux is cured. My asthma has gone. I don't get plantar fasciitis any more. I probably drink about the same amount of alcohol in a week now that I used to drink in a night. Why anyone thinks I should be concerned about any of that and worry more about 'looking tired' when I don't actually feel tired is a mystery to me.

I'm 60 so people can hardly expect to not see signs of ageing in my face at this stage anyway. If I want a facelift or some fillers to counteract this, then I'll get them. I'd rather do that, or just accept that I am a bit more wrinkly now than spend one more day being obese. It's an absolute no brainer for me.

I've had someone tell me just yesterday 'I think you've lost enough now.' Well thanks for your unsolicited opinion but I'll decide when I've lost enough and your thoughts on the matter mean jack shit to me.

I am not even close to being underweight. My BMI is 23. If I stayed exactly where I am then I'd be perfectly happy with that but if I lose a bit more then so be it. I'd have to lose another stone at least before I was even nudging the underweight section of the BMI chart. I'm wearing a size 10 from M&S and we all know M&S cut their clothes on the large side. If and when I am a size 6 then I'll be told I'm 'too thin' but until then, butt out. I am capable of looking in the mirror and seeing for myself when I'm looking worse rather than better. I'm not an idiot. If you are more comfortable with me looking on the fatter side of acceptable, that's your problem, not mine.

I actually think my WL will plateau by itself before I am in danger of being 'too thin' but if not then my provider will no doubt ask me to send a video of me standing on scales, like they did when I first went on it. I have to update on my weight every time I re-order, so I guess they will tell me when it's time to start a maintenance programme with a view to coming off altogether eventually. If they think I'm too thin they will stop providing.

I want to get very comfortably to a point where, when I am no longer on the WLIs I have a buffer zone of around 7-10 lbs where I can afford to put a bit of weight on if I take my eye off the ball for a bit, but not so much that I've put myself back into the overweight zone on the BMI chart and it's an uphill struggle to get myself back to where I feel most comfortable. So I will keep going until I reach that point (another 7 lbs or so) and can hold it steady for a few months, then I'll start coming off.

Dymaxion · 02/03/2026 09:42

but there is a compounded side effect of muscle wastage from the drug itself on top.

Do you know what the drug is and how it works ? @TightlyLacedCorset
Ozempic doesn't cause muscle wastage, losing weight does that, regardless of how you do it, unless you also incorporate regular exercise ( weights and resistance training ) and ensure you eat enough protein.
Morbidly obese people tend to have more muscle mass than slim people, especially in the bigger leg muscles, due to having to carry around excess weight constantly. It stands to reason that if they lose a lot of weight, they will also lose some of this muscle mass.

Corknut · 02/03/2026 09:42

hmm not sure it’s a documented side effect because the same would happen regardless of the method used to shift excess weight. I use WLI and have lost nearly 8 stone. I have loose skin on my legs, arms and stomach - but I have changed my life and future. Yes - the effects of huge weight loss are annoying - do I look older? Maybe, but I won’t die prematurely as a result of having several series health conditions that I no longer have since losing weight. It was on me that I carried that weight and it’s on me I have the consequences.

FurForksSake · 02/03/2026 09:44

I’ve lost six stone, using Mounjaro. Someone very rudely told me I looked at least 37 the other day. They were so pleased with themselves. I’m 43. 🤣

Anyway, yes; I look older because I don’t have fat pushing out my wrinkles. But the longer I’m a size 6-8 the more things redistribute and the less of a crone I look.

Anyone who loses weight looks older.

Kelly Osborne is struggling and so is her mother, grief, addictive personalities, the lure of slim at any cost. There is a huge fear and struggle attached to regaining weight even if you need to.

Unpaidviewer · 02/03/2026 09:45

Rosecoffeecup · 02/03/2026 09:39

You will never convince me that the faux concern over people (lets be honest, mostly women) using WLIs is anything other than jealousy and bitterness that there is now an accessible, effective aid for us fatties.

I will quite happily look older in return for being much healthier

I can't agree with this more.

"There's no long term data..." do you know what we do have long term data on? Obesity. I would rather take my chances with WLI than face the inevitable with staying mobidly obese.

itsnotagameshow · 02/03/2026 09:46

Tuliptana · 02/03/2026 07:48

Sorry but no if it starts a discussion and stops young women abusing weight loss medication that was never developed for them , then it might just save a few lives.

Its almost as if no one wamts to talk about the elephant in the room..

LOL, like no one has ever talked about this, how sanctimonious!

HeadDeskHeadDesk · 02/03/2026 09:47

I believe there is also quite a bit of evidence that, as well as looking better, it is in fact healthier to fall in the overweight (though not obese) category after a certain age.

Well if there is sufficient evidence for this then they will add a section to the BMI chart that accounts for that. Or create a new one for being over a certain age. I know they've now started saying that the 'ideal' BMI is different for men and women and different for people of different races/ethnicities, so they can do it for age too, I guess.

But until they do, and while the NHS wants to judge me by the standard BMI chart as it looks now, then that is how I will judge myself.

OwlBeThere · 02/03/2026 09:49

Tuliptana · 02/03/2026 07:14

Obviously the pictures of Kelly Osbourne are both sad and terrifying.

But a few women i know have also used this method for weight loss and their skin has lost elasticity. They look at least 10 years older. Is this side effect being under played?

Any large weightloss will cause skin to be looser/more wrinkled. It’s not a new thing only related to WLI.

Mrsredlipstick · 02/03/2026 09:49

I've been in the cosmetics industry for 45 years and weight loss will change the shape of your face. However OP have you not considered some people may have been overweight for twenty years and will have no idea how they will have aged?
The biggest skin agers are smoking, sun and booze. Lots of dieters use to smoke to curb their appetite.
Luckily there is some evidence WLI turn off drink cravings, the sun element needs spf but can't be reversed unless you use a laser.
I did use WLI for three weeks but I have gallstones so it effected me. A number of my friends have had great results including reversing diabetes. Both are much healthier. Both 70+ but look much younger.

Fwiw edible collagen doesn't work. Eat fish and drink fruit juice. Both used by the body to produce collagen.