To think it will be revealed WLI cause physical aging

[Tuliptana]

Obviously the pictures of Kelly Osbourne are both sad and terrifying.

But a few women i know have also used this method for weight loss and their skin has lost elasticity. They look at least 10 years older. Is this side effect being under played?

There is a few celebrities who have taken things too far, Arianna, Katie Price, Kelly Osbourne, they all have published trauma in common, like any substance that brings brain changes, it’s a dangerous situation for anyone who has an addictive personality or recovering from trauma as they don’t know when to stop.

You disagree that it’s better to look older than to be obese?

I think the issue is that ‘looking better’ is culturally informed - and in a culture that idolises youth and denigrates aging, it won’t matter how or why a person is thin, they would still have been considered better looking when they were younger. We need society to stop obsessing about youth and youth related ideals of beauty… but it won’t.

And posts like this just ram home how unattractive older women are deemed to be. I appreciate Kelly Osborne is not what I would call ‘old’, but at 41 she is in the ‘older’ demographic that our society starts writing off. Just look at the issues all but A lister actresses have regarding the type and number of roles available to them at that age.

There are lots of very thin looking people in Hollywood and no indication that WLI are the cause. There have always been underweight people otherwise we wouldn’t have had a fashion industry at points.

I’m not obese but I’ve definitely chosen my face over my arse.

This is so true. This oh yuck, wrinkles is such a shit attitude. I'm not going to Botox my way out of ageing to make anyone happy. I'm proud to have lost weight and am delighted that Mounjaro exists to help me stay this way. I love my healthy body. It no longer hurts and I'm rediscovering my style. I'm not going to avoid the mirror and camera anymore. I've spent decades being down on myself due to my weight and I'm not being dragged back there by people who don't like wlis.

Are you for real?

Do you know how much damage obesity does to your internal organs? Have you heard of fatty liver disease? Do you know the strain having weight-related high blood pressure puts on your heart? Are you not aware that if you have type 2 diabetes or are pre-diabetic you are likely to be insulin-resustant because your pancreas is already damaged? Do you not know that obesity also causes gall bladder issues in itself?

Used properly, WLI will save lives. They are a tool to help people who are very overweight and are struggling with their weight, or who already have insulin-resustant type 2 diabetes. Yes there are risks but these are fully explained and the benefits outweigh them in most cases.

WLI are not a quick fix, and if there's an issue with people thinking they are then that's down to dubious marketing tactics, not the WLI themselves.

How about instead of judging and making outrageously untrue statements about internal organs you just stay out of other people's business?

My blood pressure has gone from 200/97 to 124/70 in 6 weeks. My BMI is down from 42 to 39. I'm no longer in imminent danger of a heart attack or a stroke. Do I care if my skin gets a bit saggy? (It's fine so far btw). Not one jot!

Take your ridiculous faux concern and FOTTFSOF.

Chill out 😎 I’m not bashing people on WLI. I’m on them myself! Best decision I’ve ever made, lost 4 stone, worked my ass off in the gym and got a pretty banging body now! I didn’t even relate my Kelly osbourne comment to WLIs! It’s a combo of her addiction to plastic surgery and losing way too much weight (which is well-known to have been achieved with WLIs) that has made her look about 100. It’s very sad imo, she clearly has some sort of body dysmorphia, which isn’t surprising since she was in the spotlight since she was a child and grew up surrounded by intense pressure to be a size zero. I’ve got nothing against WLIs though, they’re a godsend!

Actually muscles do build in your face and provide great scaffolding, look at how much better looking men and women who properly work out are. People who weight train stay good looking into old age.

I think it's the speed at which you lose weight, when it's done in the usual way like your friend weight loss generally is slower and some weeks you don't even lose weight, with WLI the weight loss is quite rapid in a short space of time so the body doesn't have time to adapt which is why it's recommended to lose no more than 2lbs a week.

@HollywoodTease excellent post

I disagree that its better to look thinner than look older.
KO looks like she is her mother's sister. She is the picture of ill health.
I presume she had mental health issues (but she may not), but she went from being overweight to looking like a corpse.
She looked far better when she was overweight.

I know someone on it and she looks at least 10 years older. In fact, that’s being generous, I’d say about 15 years older. I’ve heard there could be problems with sight loss. I’d rather be fat than blind quite frankly.

I lost an average of 5lb a month. Your rate of weight loss is monitored by your prescriber to make sure it's not too extreme over a long period. The first month was rapid but after that it was very steady and safe.

I really think we're better off trying to make this as little about subjective perceptions of attractiveness and size as possible. We've already had at least one poster in this thread who thinks their size 14-16 friends look fine so they can't be obese, and that's a very common attitude. It's just not helpful.

It's funny though that all studies so far show the exact opposite.

https://nypost.com/2025/08/10/health/ozempic-users-aged-backwards-by-more-than-3-years-in-new-trial/

Some studies you can find on PubMed:
GLP-1R agonist treatment reversed aging-associated gene expression changes in mouse brain cells and reduced Alzheimer’s-associated aging signatures.

Genetic proxies for GLP-1R agonism were linked to increased lean mass, more fat-free mass, and better lung function—traits associated with healthier aging.

GLP-1 RAs were associated with lower risk of death and major cardio-renal events in patients ≥80 years old.

But we don't mean that, do we. We mean that if you lose fat, your skin may get, shock horror, a bit more wrinkly. Priorities.

@Tuliptana is it that you think some ingredient in WLIs cause damage to your internal organs? That’s obviously not the case. Someone having a saggy face is a result of being skinny when you’re old! Plenty of older people who are naturally skinny have the same face!

In fairness to OP, she did also invent a genuinely deranged internal organ theory several posts in. Let's give her full credit for going all out!

They obviously have EDs.

Anyone rail thin doesn’t look good in the face. I know people (average people) who have used the injections reasonably and look great.

I think KO is a poor example to use given she's a new mother, in the public eye going through a very publicised close bereavement. Is it any wonder she's struggling to keep weight on even without the use of WLI? I think you could easily have started this thread without doing it off her back tbh.

I think yes, there's issues with regulation and people should be using them sensibly and truthfully, however when you think about the effects of obesity on the body, I'm not sure the known risks around wli are any worse. I also would rather feel healthy than look young.

WLIs increase the risk of acute pancreatitis, which is a risk factor for pancreatic cancer. Rapid weight loss also increases the likelihood of gallstones, which are a risk factor for pancreatitis and pancreatic cancer. I’m not saying it’s a huge risk or worse than obesity, but we just don’t know how big it is yet.

Well you could have both if you're really lucky, sight issues are a side effect of diabetes and many obese people get type 2 diabetes.

Keeping my fingers crossed for you.

My only criticism of WLIs, if it an be called a criticism at all, is that there remains a huge risk that people will simply pile the weight back on when they stop. But there's no magic fix for that. We are just going to have to hope that, having lost the weight relatively painlessly, we all enjoy being slimmer and fitter with more energy and looking great in our clothes and having more confidence so much that we are hugely motivated to stay there and not ever allow things to get out of control again.

With a bit of effort and common sense it surely has to be easier to maintain a healthy weight than to achieve it from a starting point of obesity. If we can't at least manage that then we probably deserve all we get. But that's not the fault of WLIs any more than it's the fault of low carbing, or intermittent fasting or Slimmers World or anything else. You need to be mentally prepare to put the work in and change your attitudes and habits forever once your target weight has been achieved. It's not going to be easy but no-one ever promised it would be.

Oh, and a second critisicm of WLIs and this is a criticism, is that I definitely don't eat more healthily than I used to when I was fat. 😂I just eat much, much less in general, but it's certainly not better food. Frequently it's just junk. It's just fuel and I don't really care what it is.

My interest in cooking has disappeared so I take the path of least resistance with food. When I get hungry, I am suddenly ravenous and want to eat now so I eat whatever is to hand. I'll be done in six mouthfuls and push the plate away. If I buy a supermarket sandwich I'll eat half of it. But depending on where I am and what is to hand, it might be a pile of biscuits or banana or a McDonalds or a tin of ravioli. Something low effort and not always fresh or healthy.

Because I have little interest in food now, I struggle to meal plan ahead. I don't want to think about food, it's a chore. I get to the supermarket and wander around not fancying any of it. This means even if I've bought plenty of fresh ingredients because I know I should, I get to dinner time and I have no motivation to cook them. I'll often end up having a half a tin of tin of soup and some toast for dinner, instead of the interesting and freshly prepared meals with lots of veg that I used to make. I know this is terrible, but it is what it is. I try to make sure I at least eat a few pieces of fresh fruit each week and I am losing weight in spite of an often terrible diet, so I see it as a temporary blip that's helping me get where I need to be, even though I am aware it's less than optimum.

My fear is that when my love of cooking eventually returns, so will my appetite and my lack of self control. This is where I will really need to mentally prepare myself to transition back to normal life with no WLIs.

Kelly Osbourne had gastric sleeve surgery in 2018 so not sure WLI have anything to do with it in her case.

Chronic gallstones and pancreatitis increase the risk of biliary cancers. This is due to the chronic inflammation associated with the chronic nature of the illnesses. There is a small increase chance of pancreatitis and gallstones which could lead to an increase risk in cancers if those illness s became chronic. The risk appears to be for acute though.

And all that is really conjecture on the amount of increased risk.

what we do have solid evidence for is the risk of obesity, poor diet, smoking and diabetes. They are known risk factors. So if we control the diabetes and the obesity the risk is more than likely overall lower.