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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

To think it will be revealed WLI cause physical aging

830 replies

Tuliptana · 02/03/2026 07:14

Obviously the pictures of Kelly Osbourne are both sad and terrifying.

But a few women i know have also used this method for weight loss and their skin has lost elasticity. They look at least 10 years older. Is this side effect being under played?

OP posts:
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18
WatchingWong · 02/03/2026 14:07

But pretty much every drug has the potential to be abused. People lie to get all kinds of medications all the time. Why are you so concerned about people lying to get WLIs (which I agree they really shouldn't be doing) over anything else?

Hundreds of people die from taking painkillers they buy in the supermarket every year, and even more die by lying to obtain prescription meds. No one seems to be hand-wringing about how terrible they are because some people choose to abuse them.

Notsosweetcaroline · 02/03/2026 14:07

FurForksSake · 02/03/2026 14:05

Glp-1s have been in use for type-2 diabetes since 2005 and for weight since 2014. I think we have a fair amount of research on the long term side effects.

It doesn’t matter how safe they are, it doesn’t even matter than poor Kelly is unwell and not on them, what matters is finding an outlet for their resentment and envy to these posters, it’s pointless, it runs too deep for them.

Binus · 02/03/2026 14:08

LimeGoose · 02/03/2026 14:01

i don’t think anyone should have access to it if they aren’t clinically obese, but they obviously do and I don’t have the power to stop that. Unfortunately the fanatical responses on this thread have told me we’re probably too far down the line to go into reverse now. I just hope the long-terms side effects are the best case scenario, which I absolutely don’t rule out.

If you think obese people should be able to take them, that's something. But the obese population alone is still going to make them pretty widespread! Where do you stand on maintenance dosing for the formerly obese?

A tip, btw, if you don't like the responses you've had on this thread you'd probably do better to acknowledge the risks of remaining obese. It's not clear from your posts that you understand an already obese person is unlikely to be able to achieve and remain at a healthy BMI without WLIs.

JHound · 02/03/2026 14:09

No it won’t. They likely did not notice lost elasticity due to fat filling their face out.

But this is just the monthly WLI thread. Personally an aged face is a fat lesser threat to my health and wellbeing than obesity.

Binus · 02/03/2026 14:14

Notsosweetcaroline · 02/03/2026 14:03

Do you really care, like really, do you think this poster has more information than the scientists and doctors at the world health organisation or the fda or mhra, or any other authority globally, as I’d bet good money her opinion is based in nothing more than jealousy and resentment. So who cares.

The fact that the poster obviously does not have access to more information is what makes me interested in why she holds the opinions she does in the first place! I think the things people come out with about WLIs and obesity are fascinating.

I of course respect anyone who doesn't give a shit and simply wishes to get on with their WLI taking lives.

Ponderingwindow · 02/03/2026 14:25

My blood pressure is better. My cholesterol and A1c are the best they have been in years. These are all signs of better health and things that tend to worsen with age. I also look better.

My doctor also has me on a slow regime. this gives things like skin time to adapt. It also means that healthy habits have to be a part of it. It’s a slow and steady kind of weight loss, but it’s working. Some
day I will reach a healthy weight and need to come up with a new plan.

I suspect the problem with WLI is that people are going too far and too fast. They keep taking them at the highest doses even when they should stop or at least scale back to a maintenance dose.

Notsosweetcaroline · 02/03/2026 14:26

Binus · 02/03/2026 14:14

The fact that the poster obviously does not have access to more information is what makes me interested in why she holds the opinions she does in the first place! I think the things people come out with about WLIs and obesity are fascinating.

I of course respect anyone who doesn't give a shit and simply wishes to get on with their WLI taking lives.

I have seen so many of these now, usually the same posters over and over again, often different names, and I completely beleive it is always envy and resentment behind it, nothing more. Nothing else makes logical sense as it is such utter nonsense and emotional reaction nonsense at that.

I also find it fascinating though. Watching how disturbed these guys are. That we can get th4 drugs, how much they hate it with every part of them.

SilenceInside · 02/03/2026 14:32

@Ponderingwindow "I suspect the problem with WLI is that people are going too far and too fast. They keep taking them at the highest doses even when they should stop or at least scale back to a maintenance dose." - but what is "the problem" that you are concerned about? Which people, and how many? Or is this a theoretical issue?

WutheringTights · 02/03/2026 14:44

My worry is that if you don’t hit the weights very hard, people on WLIs lose a lot of muscle mass. If you hit perimenopause, a period when you lose a lot of muscle mass anyway, with less muscle to start with, it’ll lead to much more frailty. I think we’ll see more people with frailty-related conditions at an earlier age, eg falls, mobility issues, and the related care needs. Only time will tell whether this is still better than suffering obesity-related illness. Whether your face looks old or not is of much lesser concern.

Notsosweetcaroline · 02/03/2026 14:48

WutheringTights · 02/03/2026 14:44

My worry is that if you don’t hit the weights very hard, people on WLIs lose a lot of muscle mass. If you hit perimenopause, a period when you lose a lot of muscle mass anyway, with less muscle to start with, it’ll lead to much more frailty. I think we’ll see more people with frailty-related conditions at an earlier age, eg falls, mobility issues, and the related care needs. Only time will tell whether this is still better than suffering obesity-related illness. Whether your face looks old or not is of much lesser concern.

I think this is well publicised now and nearly everyone knows. So I don’t think you need to spend too much time worrying.

AppleDumplingWithCustard · 02/03/2026 14:50

Tuliptana · 02/03/2026 07:43

Im talking about who are buying it online and are lying about their BMI. This is a huge market but if not monitored by a qualified doctor, who knows what damage is being done.
They wont be getting regular blood tests .

Why are you so bothered about other people? You seem quite desperate to blame WLIs.

Spaghettion · 02/03/2026 14:54

Tuliptana · 02/03/2026 07:21

Yes but its not just a 'bit older' its drastic aging which makes you wonder what its doing to internal organs. It seems more profound in women who were not obese to start with but used them anyway.
I guess it could be lack of nutrition or dehydration but the effects are scary.

Kelly Osbourne is a terrible example, she clearly has an eating disorder.
I don’t know a single person on Mounjaro that has aged 10 years in the face, they’ve maybe lost a little elasticity but that would have been the case no matter if they’d jabbed or gone to slimming world. As others have said I’d rather look a little older than be over weight.

MyLuckyHelper · 02/03/2026 14:57

SuzyFandango · 02/03/2026 08:07

I don't really care about whoever Osborne.

I do care about my friends though....i live in a well off south east village, most of my friends (all in our forties) had size 14/16 "mum bods" and have eagerly found online pharmacies to give them mounjaro. One has yoyo-ed down to a size 6, stopped taking it, piled weight back on incredibly fast & is back on it. Another told me she had a horrendous run of stomach issues when taking it.

I do think at some point the supply to these people will be more strictly regulated, they were barely even overweight let alone obese so this is unlikely to be providing them with health benefits. The "checks" seem to be incredibly easy to lie to get around.

A friend is a doctor doing some specialist research into obesity and said that there are concerns around what WLI drugs do to your own endocrine function, with some people gaining weight more rapidly when they stop taking them. This would worry me a bit - sure you could stay on a "maintenence dose" forever but what will the pharma companies charge you for that?

I have lost 7 stone on WLI. I also previously lost 7 stone many years ago 'naturally' and regained it all (and more).

I am currently 12 stone 8 and a size 12/14. BMI isn't perfect, but it is the measure we have & I am 30.2 on the BMI scale. I am very definitely still obese. A size 16 is quite likely obese, or at the very least overweight.

DarkForces · 02/03/2026 15:06

WutheringTights · 02/03/2026 14:44

My worry is that if you don’t hit the weights very hard, people on WLIs lose a lot of muscle mass. If you hit perimenopause, a period when you lose a lot of muscle mass anyway, with less muscle to start with, it’ll lead to much more frailty. I think we’ll see more people with frailty-related conditions at an earlier age, eg falls, mobility issues, and the related care needs. Only time will tell whether this is still better than suffering obesity-related illness. Whether your face looks old or not is of much lesser concern.

You spend your time wondering if I'm weight lifting sufficiently for a healthy old age? You're really concerned about that? There's a much better chance I'll make old age now but feel free to light a candle

AnotherHormonalWoman · 02/03/2026 15:06

Notsosweetcaroline · 02/03/2026 13:47

Kelly has said she is mentally struggling right now, and is struggling to eat due to it. Let’s all believe hee shall we, rather than attack how she looks, accuse her of lying about not taking the injections now or lying about how much she eats and she’s a secret deficiency. Let’s just. Shall we.

Alright that's fine, you can chill. I don't follow her and hadn't heard that she has said that she is struggling to eat - but if its true that she has a gastric band (as another person on here has said) then the struggling to eat makes it even more likely that she's deficient in important nutrients, as well as calories.

I hope that whatever is going on with her health, that she returns to better health soon.

HeidiLite · 02/03/2026 15:18

WutheringTights · 02/03/2026 14:44

My worry is that if you don’t hit the weights very hard, people on WLIs lose a lot of muscle mass. If you hit perimenopause, a period when you lose a lot of muscle mass anyway, with less muscle to start with, it’ll lead to much more frailty. I think we’ll see more people with frailty-related conditions at an earlier age, eg falls, mobility issues, and the related care needs. Only time will tell whether this is still better than suffering obesity-related illness. Whether your face looks old or not is of much lesser concern.

it is much easier to work out if you don't have a few extra stones of fat on you.

WutheringTights · 02/03/2026 15:30

DarkForces · 02/03/2026 15:06

You spend your time wondering if I'm weight lifting sufficiently for a healthy old age? You're really concerned about that? There's a much better chance I'll make old age now but feel free to light a candle

Maybe I should clarify. I was trying to be kind in my post. It was actually a passing thought along the lines of how we will fund care homes for people who are there 10 years earlier than they would have been due to WLI-induced frailty. Inspired by seeing reports of care home costs in the news. Literally no one I know on WLI is following the guidance on exercise. HTH.

FurForksSake · 02/03/2026 15:36

Sarcopenia is already a massive and growing issue. We really should be pushing adults from 40 onwards to consider their muscle and how to maintain it. I take a decent dose of creatine every day and when I am well enough I use weights and resistance bands. GPs should be prescribing exercise classes for over 65s and there should be more national advice on it.

Obesity doesn’t protect from sarcopenja, carrying excess weight leads to insulin resistance and reduced mobility usually so you will end up with muscle wastage regardless.

SilenceInside · 02/03/2026 15:37

“WLI frailty” is a new one for the bingo card I think. You are seriously concerned about how society will fund care homes to house people who are “frail” because of losing weight? Perhaps you would rather we all just died of obesity related conditions instead, although that would be unlikely to be cheaper. If money is the concern.

DarkForces · 02/03/2026 15:41

WutheringTights · 02/03/2026 15:30

Maybe I should clarify. I was trying to be kind in my post. It was actually a passing thought along the lines of how we will fund care homes for people who are there 10 years earlier than they would have been due to WLI-induced frailty. Inspired by seeing reports of care home costs in the news. Literally no one I know on WLI is following the guidance on exercise. HTH.

So very very kind. Thanks

WutheringTights · 02/03/2026 15:48

SilenceInside · 02/03/2026 15:37

“WLI frailty” is a new one for the bingo card I think. You are seriously concerned about how society will fund care homes to house people who are “frail” because of losing weight? Perhaps you would rather we all just died of obesity related conditions instead, although that would be unlikely to be cheaper. If money is the concern.

It’s possible to hold more than one thought at the same time. I can be happy that many people have now found a way to manage life-limiting obesity-related disease, and also wonder what the long term impact will be on our health and social care system. It doesn’t make me a bad person and isn’t a value judgement on anyone currently using WLI. But it is something that governments need to plan for.

DarkForces · 02/03/2026 15:53

Well the evidence is that I'll live a longer healthier life.

Notsosweetcaroline · 02/03/2026 15:59

WutheringTights · 02/03/2026 15:30

Maybe I should clarify. I was trying to be kind in my post. It was actually a passing thought along the lines of how we will fund care homes for people who are there 10 years earlier than they would have been due to WLI-induced frailty. Inspired by seeing reports of care home costs in the news. Literally no one I know on WLI is following the guidance on exercise. HTH.

Wow, you sit and wonder how we will fund care homes for people who lose weight on weight loss injections and don’t strength train. Good grief, what a charmed life you must lead where you sit and worry about something so unlikely to occur.

like many people my blood tests were all very healthy after a year on the drugs, smack bang in the middle of the health range, and I work out religiously, how many people do you know, in real life, who are approaching old age and they have no time to pull it back and are on the drugs and not working out.

I guess at least if we stay obese we won’t need the care homes as we will all die. So I guess there is that.

SilenceInside · 02/03/2026 16:00

@WutheringTights I was not implicitly or explicitly suggesting that you were only capable of holding more than one thought at a time in your head.

I don’t think any government actually plans long term about anything, as much as they make statements about long term goals. The nature of our short term political landscape means that 4 or 5 years is about as much long term thought as we get, from one election to the next. Then subsequent governments are stuck with the previous one’s half implemented plans which they don’t want to implement…. and so it goes on.

People using WLI to lose weight are overall healthier than remaining obese, this is overall a benefit for society.

Notsosweetcaroline · 02/03/2026 16:01

WutheringTights · 02/03/2026 15:30

Maybe I should clarify. I was trying to be kind in my post. It was actually a passing thought along the lines of how we will fund care homes for people who are there 10 years earlier than they would have been due to WLI-induced frailty. Inspired by seeing reports of care home costs in the news. Literally no one I know on WLI is following the guidance on exercise. HTH.

Actually,now I think about it,maybe they can use some of the billions the nhs will save in reduction of cancers, heart attack, strokes, diabetes, joint replacement, fatty liver, high cholesterol, high blood pressure etc treatment and use that to fund the care homes for all us elderly frail people? Would that help you sleep better at night?