This is one of those where there’s no perfect answer.
As other posters have pointed it out splitting it 4 adults means that the couple are paying a higher proportion of the present aspect of the payment. However you could also argue they’re getting their teen for free. The Spouse of the sibling may also feel like they’re coming along out of familial obligation rather than really wanting to be there, so may not want to pay for the privilege.
Split by room? Well then you need to know the layout of the place? Are some rooms bigger? En-suites? Does teen get an inferior room?
Are the siblings similar in age and on different life paths or is one just graduated and on a starter salary whilst the other is 10+ years older and has had much more time to establish themselves?
Will anyone be getting parent any supplementary gift? Who knows?
I think the difference in cost also matters. Is it £50 or £200 difference depending on how it is split?
Then you can also throw in how are food costs going to be split? If there’s a big shop will it be per family? Per person? What about meals out?
I think if you aren’t going on a trip with people where you all have a generous mindset in the first place all these things can get quite fraught.
Overall OP only you know the nuances of all of this. I think a good natured discussion needs to take placed between the siblings and parent to come to a split you’re all happy with and where no one feels resentment. This will be different in every family and every situation. But going forward I would advise agreeing the split of costs before booking anything.