The NOAEL is determined by experiments on animals that last weeks or months. If a human is ingesting Sodium lauryl sulfate in small amounts over decades then the NOAEL is not much help in determining how much of a problem it will be. That could only be determined by a longitudinal cohort study and only then if they asked the right questions.
Skin and Eye Irritation: SLS can strip away natural oils, leading to dryness, irritation, or allergic reactions—especially in people with sensitive skin or conditions like eczema.
Cumulative Exposure: While most studies involve high concentrations not typical of everyday use, there’s concern about the long-term effects of repeated, low-level exposure. Research on this is still limited.
Toxic to aquatic life: Studies show that SLS can damage the cell membranes of fish and amphibians, impairing nutrient absorption and waste expulsion. In some cases, it caused 100% mortality in zebrafish embryos at higher concentrations.
Developmental effects: In early life stages of fish and amphibians, SLS exposure led to malformations, reduced hatching rates, and altered heart rates.
Community-level disruption: Even at low concentrations, SLS reduced populations of Daphnia magna, a key grazer in freshwater ecosystems. This could ripple up the food chain, affecting fish and other predators.
Ecosystem imbalance: By harming sensitive species like amphibians and microcrustaceans, SLS can shift the balance of aquatic communities, potentially leading to algal blooms or reduced biodiversity.
And you're happy to have this chemical in your gut? It might be only half the NOAEL but I wouldn't risk the possible long-term effect of harm to my gut bacteria or the cells lining the gut. I also don't buy dispersible aspirin containing SLS.