to think more negative effects will come out from Ozempic use?

[nameey]

Just read that the 30 year old singer Avery has been diagnosed with osteoporosis due to Ozempic use. Looks like this could be the start of many conditions coming out.

I know Ozempic is incredibly helpful for a lot of people but losing weight but then having osteoporosis does not seem worth it.

AIBU?

Then why are you going in about overweight people who have access to the jabs?
Because if they are under a BMI=28, they can’t….. that’s the whole point!!

Thanks for that explanation.

I found this statement odd: "Time will tell how long people need to maintain for before their bodies no longer tend towards weight gain after a period of obesity..."

It's as if you are saying their bodies are doing this odd thing of tending to gain weight, with no input from the person inhabiting the body.

I think, also, it has been established that most people will gain back most of the weight they have lost on WLI once they stop the injections. So...

In the interest of a balanced argument let's put forward what obesity feels like to those suffering from it.
I would eat a well balanced breakfast with fibre and protein that is meant to keep me full. By the time I get to work 2 hours later at 9 I am starving, feel like I haven't eaten in days. I can try my best to ignore this but it is draining and takes all my energy so I cave and eat something. Fruit makes me more hungry. This viscious cycle just continues all day and it is exhausting.

Exercising to the point I feel ill does somewhat temporarily give me rest bite but not always. I never understood how people were thin and not in a perpetual state of fatigue and starvation. Now 3 months on WLI and I feel normal. My weight is now high overweight and I am able to keep up with my kids and enjoy them without aches and pains.

I read this interesting analogy on redit that I feel resonates with me.

"Sometimes I think about how I could explain to my mom what it's like to take MJ and why it's so special and a miracle etc. After you take MJ for the first time you realize what was so different about you all the time. It's like you need to breath twice as much air as everybody else. And everybody else tells you to just "breath less". Then you try so hard but your body fights you for air. And then you take MJ and realize nobody even needs to think about breathing and it was so so hard for you because you were suffocating 24/7.
My mom told me time and time again to "just don't snack, just don't eat so much" and now I'm like wow if that's how you feel all the time - I would never have stuffed myself in the first place.
Another I think about a lot is that you feel like you were an alcoholic but you suddenly aren't anymore and you didn't even knew you were addicted."

Because some do a maintenance dose and some dont, why is that hard to understand

There are online pharmacies where I can get my (prescribed) migraine meds, and my (prescribed) nasal sprays. However not all online pharmacies offer them and might offer different types or different dosages. So if and when I run out due to chaos at my chemist and GP (frequently), I choose the one that can prescribe for me.

Whats the confusion about that?

I’m embarrassed for you that you are now resorting to personal insults when I’ve been nothing but polite.

If Im wrong about stuff I’m happy to be educated. There is no reason to be rude.

@LionME people with a BMI of 27 or higher can get a prescription for WLI, if they have a weight related health condition, or if they are one of a list of ethnicities where being obese is categorised as having a BMI of 27 or higher. Those are the MHRA approved prescribing criteria.

Ah yes… the whole, it’s just a will and laziness issue…

Thanks for finally coming out clean on your prejudice and ignorance of scientific facts.

That’s a different situation where pharmacies don’t stock particular drugs.

What is less clear is why pharmacies that do stock weight loss drugs and have been prescribing them to an individual say there is a point they will no longer offer them.

Yes, I’m aware.
As it should be too as, for example, criteria fir diabetes/BMI are also different according to ethnicities too.

@ThatsNotMyTeen
If you spend any time on the weight loss threads, you'll see that people are very concerned about side effects in the long and short term. Dealing with these safely and effectively is a very hot topic and is invariably responded to by advising the poster to seek medical advice. And very few people start taking WLIs injections without researching them first and then weighing up the potential costs and benefits, often in partnership with their GPs.

Your assertion, therefore, that they don't know and/or don't care about SEs and will take any quack remedy is just an extension of the belief that fat people are stupid, lazy and greedy and tells us a lot about you and your motivations in this thread.

Well I’m going to go with the regulatory authorities in terms of the drugs safety and appropriateness, however if you can post your medical credentials and why you know better than the mhra and fda etc, we are all ears, go for it.

and I mean this gently but no one needs to make excuses to you. As quite frankly you’re irrelevant.

Because some don’t prescribe for maintenance but others do

I honestly beleive the folks posting the silly negative stuff, all to a one unable to back it up, are relying on the fact they are anonymous key board warriors, just letting their true feelings out.

because if we saw them in real life, we would know exactly why they feel like that, and we would turn our heads away in embarassment and pity for them.

@Twiglets1
I never said I was an expert on prescribing practices.

You didn't need to. You criticised current prescribing practices which suggests you think you know what these are - you clearly don't. Get it now?

You’re the main keyboard warrior on this thread with your personal attacks. I doubt you talk to people like that in real life or at least I hope you don’t.

The example given is a possible effect of abusing Ozempic, because this isn’t someone who should have been prescribed it in the first place. Whether it was the cause of the osteoporosis also isn’t clear.

There are risks associated with these weight-loss drugs, including problems associated with too much muscle loss, and evidence of a raised risk of certain conditions, like arthritis, pancreatitis and vision loss (see links below). As more people take them for longer, more problems will probably emerge.

For many people who are obese/diabetic these risks may well be cancelled out by the benefits of the weight loss – all drugs have side effects, and there are plenty of conditions where the risk/benefit profile is weighed up accordingly. But I do think we are going to see a lot of problems resulting from people who don’t really need to use the drugs using them anyway. Controls on these drugs really need to be tightened, they should not be made available to anyone who doesn’t have a significant amount of weight to lose and should only ever be prescribed after an in-person consult and examination.

www.nature.com/articles/s41591-024-03412-w

jamanetwork.com/journals/jamaophthalmology/fullarticle/2820255

@Twiglets1 "What is less clear is why pharmacies that do stock weight loss drugs and have been prescribing them to an individual say there is a point they will no longer offer them."

Well I would hope that all pharmacies would stop prescribing if someone's BMI was underweight or approaching the underweight range. Then apart from that, it's down to a combination of business decisions and how they want to operate. Some make it simple and have a specific BMI cut off which is not negotiable. Business wise, it makes it easier to handle customers and predictable what the next steps are. Asda for example specify 23.5 BMI, I think, as their cut off. That's their business decision. Others, like Oushk, have several different maintenance plans you can move onto, they have a different business model and are happy to have more individualised discussions.

Criticising online pharmacies that dispense weight loss drugs to slim people pretending to have a weight problem obviously isn’t right. This practice does happen as is clear from certain celebrities. It obviously is possible to game the system with online consultations although most people are honest I’m sure.

Im not criticising all current prescribing practices or claiming to be an expert. But if they’ve recently tightened up the rules that suggests they felt they needed to as there were problems with the previous ones.

Great journal articles thank you.

From the first one:

There was an increased risk of gastrointestinal disorders, hypotension, syncope, arthritic disorders, nephrolithiasis, interstitial nephritis and drug-induced pancreatitis associated with GLP-1RA use compared to usual care.

From the second one:

This study’s findings suggest an association between semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy

@nameey both of those issues have already been discussed in detail on the thread already.

Is this supposed to be a ‘gotcha’? Not one person has said these drugs don’t have possible side effects or that some others may become apparent in the future. But that if you’re taking this medication, you’ve weighed up the risks compared to being obese and decided it’s worth it.

Yep and here's the part of the abstract you omitted
"Compared to usual care, GLP-1RA use was associated with a reduced risk of substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimer’s disease and dementia), coagulation disorders, cardiometabolic disorders, infectious illnesses and several respiratory conditions."

All drugs carry side effects / risk as stated over and over again. The risks of obesity far outweigh the risks of the drug.

@Twiglets1 which celebrities who don't meet the prescribing criteria have been prescribed WLIs by an online pharmacy? I've seen cases where celebrities have been prescribed in the US, which has a totally different healthcare model to the UK. I've seen cases where celebrities have used substances bought from beautician- type sources which could be anything and certainly aren't the licensed medication made by Novo Nordisk/Ei Lilly. I've seen cases where celebrities have been given medication by a friend of a friend passing on their prescription medication. Just wondering which examples you're thinking of?

The guidelines for pharmacies have been clarified which I'm glad about. Most prescribers meet the clarified requirements. Certainly the one I'm using has not had to make any changes to how they prescribe and what checks they do.

I completely agree with that.

This thread though is about the long term effects of using weight loss drugs and whether we think more negative effects will come out in future or not.