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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

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to think more negative effects will come out from Ozempic use?

692 replies

nameey · 22/02/2025 11:12

Just read that the 30 year old singer Avery has been diagnosed with osteoporosis due to Ozempic use. Looks like this could be the start of many conditions coming out.

I know Ozempic is incredibly helpful for a lot of people but losing weight but then having osteoporosis does not seem worth it.

AIBU?

OP posts:
Tulipsandaffodils · 23/02/2025 13:15

SwingTheMonkey · 23/02/2025 13:10

Is this supposed to be a ‘gotcha’? Not one person has said these drugs don’t have possible side effects or that some others may become apparent in the future. But that if you’re taking this medication, you’ve weighed up the risks compared to being obese and decided it’s worth it.

I think the fact the op deliberately excluded the positives, shows she’s not interested in a balanced discussion.

lettyraines · 23/02/2025 13:16

Caffeineneedednow · 23/02/2025 13:12

All drugs carry side effects / risk as stated over and over again. The risks of obesity far outweigh the risks of the drug.

Absolutely, for morbid obesity. But for, say, class 1 obesity, I don't think they do. Certainly, if your BMI is in the overweight range, in my view it is madness to take such risks with your future health. But of course people do.

SilenceInside · 23/02/2025 13:18

@lettyraines why do you think the MHRA came to a different conclusion, that GLP-1s are appropriate for people with Class 1 obesity or overweight (BMI > 27) with weight related health conditions?

roastedrapidly · 23/02/2025 13:18

It's not the drug causing harm, it's people's misuse of it that does the harm.

Caffeineneedednow · 23/02/2025 13:20

Twiglets1 · 23/02/2025 13:15

I completely agree with that.

This thread though is about the long term effects of using weight loss drugs and whether we think more negative effects will come out in future or not.

This class of drugs have been on the market for 30 years. So from a drug development point of view we have 30 years of data.

The known side effects are worth the risk. The possibility of unknown side effects emerging seems to be used a stick to beat people. I am not saying they won't emerge but given the long term existing data it is unlikely they will be see enough to warent withdrawal.

In fact more likely is the drugs use will be expanded for a variety of other conditions

lettyraines · 23/02/2025 13:21

SilenceInside · 23/02/2025 13:18

@lettyraines why do you think the MHRA came to a different conclusion, that GLP-1s are appropriate for people with Class 1 obesity or overweight (BMI > 27) with weight related health conditions?

Well, I guess they have a different opinion to me.

BellaCiao23 · 23/02/2025 13:21

MiserableMrsMopp · 22/02/2025 19:33

Why aren't you posting about them then @nameey ?

Perhaps because the thread is about Ozempic? I’m concerned about alendronic acid.

Twiglets1 · 23/02/2025 13:22

SilenceInside · 23/02/2025 13:14

@Twiglets1 which celebrities who don't meet the prescribing criteria have been prescribed WLIs by an online pharmacy? I've seen cases where celebrities have been prescribed in the US, which has a totally different healthcare model to the UK. I've seen cases where celebrities have used substances bought from beautician- type sources which could be anything and certainly aren't the licensed medication made by Novo Nordisk/Ei Lilly. I've seen cases where celebrities have been given medication by a friend of a friend passing on their prescription medication. Just wondering which examples you're thinking of?

The guidelines for pharmacies have been clarified which I'm glad about. Most prescribers meet the clarified requirements. Certainly the one I'm using has not had to make any changes to how they prescribe and what checks they do.

Lottie Moss is someone who comes to mind as she was never overweight & suffered very bad side effects to the extent of being hospitalised.

lettyraines · 23/02/2025 13:23

Caffeineneedednow · 23/02/2025 13:20

This class of drugs have been on the market for 30 years. So from a drug development point of view we have 30 years of data.

The known side effects are worth the risk. The possibility of unknown side effects emerging seems to be used a stick to beat people. I am not saying they won't emerge but given the long term existing data it is unlikely they will be see enough to warent withdrawal.

In fact more likely is the drugs use will be expanded for a variety of other conditions

Since 1995?

Tulipsandaffodils · 23/02/2025 13:23

Twiglets1 · 23/02/2025 13:15

I completely agree with that.

This thread though is about the long term effects of using weight loss drugs and whether we think more negative effects will come out in future or not.

But no one knows this, how could they, no one can see into the future, how can we even have a discussion on it.

what we know is the drugs were in trials for 15 years, that the peptides have been in common use under different guises for over 20 years, that over 17 million or on them in the USA alone and not one death or serious illness directly attributed to the drugs, that the testing requirements since thalidomide have been highly tightened up, hence why it is 15 years of testing and trials post development.

does this mean something won’t come out in another 20 years and that 35 years isn’t enough, no, but asking people to speculate in will something appear at some point is just daft especially when it is people with limited knowledge of the drugs never mind a scientific or medical background.

look at the op, she actually seemed to think the drug caused the osteoporosis, even though the article clearly stated otherwise, we have seen multiple people who don’t understand the drugs, don’t even know the prescribing guidelines.

it’s clear the people taking them are the ones who have researched and are the most knowledgeable and the people who are posting the negativity have not.

sure we will all engage in a discussion on the validity of testing from the authories, be it the fda, mhra or any other market you wish to look at, be in China, or France, whatever. But it is clear the people posting simply don’t have the knowledge to do this, so pretending we can have some sort of debate on the testing methodology of prescription drugs is silly.

Caffeineneedednow · 23/02/2025 13:25

lettyraines · 23/02/2025 13:16

Absolutely, for morbid obesity. But for, say, class 1 obesity, I don't think they do. Certainly, if your BMI is in the overweight range, in my view it is madness to take such risks with your future health. But of course people do.

But if your BMI is in the overweight range ( has to be over 27) the only way you are getting the drug legally is if you already have a weight related condition. Implying that yes your weight has already began to impact your health.

Obesity, even class 1, has a detrimental impact on health. We have normalised it so much that we think of it as a cosmetic issue. It is not it is medical and increases your risk of a variety of secondary conditions. And decreases life expectancy.

This is not a cosmetic argument but a medical one.

Tulipsandaffodils · 23/02/2025 13:27

Twiglets1 · 23/02/2025 13:22

Lottie Moss is someone who comes to mind as she was never overweight & suffered very bad side effects to the extent of being hospitalised.

Lottie moss got the drug from a friend of a friend. She also took a much higher dose than even if she was eligible would have made her very unwell. She was not prescribed it. Can you find no one who has taken the drug legitimately and suffered an issue? So it’s just some minor celebs who got on the black market?

Glorybox2025 · 23/02/2025 13:28

@lettyraines

It's as if you are saying their bodies are doing this odd thing of tending to gain weight, with no input from the person inhabiting the body.

No, but once your fat cells have been damaged by obesity (which yes, is caused by eating in excess of caloric needs over a significant period of time, whatever the reasons for that may be) they both expand and multiply, which impacts the body's metabolism and hormonal response, making it harder to maintain weight loss as the body is actively fighting to regain the weight. The damage is caused by the person's initial actions ie overeating, but once the damage is caused it is very hard to undo.

I think, also, it has been established that most people will gain back most of the weight they have lost on WLI once they stop the injections. So...

Yes, that links to the point made above. There is little research into the long term treatment of obesity but these drugs will enable better research to be carried out which will help us understand if/when the body recovers from these effects and people with obesity are no longer at greater risk of becoming obese again.

Twiglets1 · 23/02/2025 13:28

Caffeineneedednow · 23/02/2025 13:20

This class of drugs have been on the market for 30 years. So from a drug development point of view we have 30 years of data.

The known side effects are worth the risk. The possibility of unknown side effects emerging seems to be used a stick to beat people. I am not saying they won't emerge but given the long term existing data it is unlikely they will be see enough to warent withdrawal.

In fact more likely is the drugs use will be expanded for a variety of other conditions

I’m not trying to beat people with a stick for using Ozempic/Wegovy/Mounjaro as a weight loss drug. I also doubt they will ever be withdrawn and may well be expanded for other conditions in future. But I also think that more negative effects may come to light which is the title of the thread.

Tulipsandaffodils · 23/02/2025 13:28

Caffeineneedednow · 23/02/2025 13:25

But if your BMI is in the overweight range ( has to be over 27) the only way you are getting the drug legally is if you already have a weight related condition. Implying that yes your weight has already began to impact your health.

Obesity, even class 1, has a detrimental impact on health. We have normalised it so much that we think of it as a cosmetic issue. It is not it is medical and increases your risk of a variety of secondary conditions. And decreases life expectancy.

This is not a cosmetic argument but a medical one.

I suspect for many posting it is a cosmetic issue for them. Hence we see responses like this.

Tulipsandaffodils · 23/02/2025 13:29

Twiglets1 · 23/02/2025 13:28

I’m not trying to beat people with a stick for using Ozempic/Wegovy/Mounjaro as a weight loss drug. I also doubt they will ever be withdrawn and may well be expanded for other conditions in future. But I also think that more negative effects may come to light which is the title of the thread.

Ok then explain why you feel like this, after 15 years of trials and 20 years of use, and multiple health authorities globally approving. Can you explain it?

Twiglets1 · 23/02/2025 13:32

Tulipsandaffodils · 23/02/2025 13:27

Lottie moss got the drug from a friend of a friend. She also took a much higher dose than even if she was eligible would have made her very unwell. She was not prescribed it. Can you find no one who has taken the drug legitimately and suffered an issue? So it’s just some minor celebs who got on the black market?

Did she? Can you back that up?
I’m sure I can find other examples but I don’t really have to. I think it might just be you who is denying that anyone at all has lied about their weight to get access to these drugs, celebrity or not. There is huge pressure particularly on young women these days to be slim, especially those in the public eye.

Twiglets1 · 23/02/2025 13:35

Tulipsandaffodils · 23/02/2025 13:29

Ok then explain why you feel like this, after 15 years of trials and 20 years of use, and multiple health authorities globally approving. Can you explain it?

Simply because Ozempic hasn’t been widely used for weight loss purposes until fairly recently.Now there’s been an explosion of people using it for that reason.

I think as more people use a drug more side effects become known and that is the same for all drugs.

Tulipsandaffodils · 23/02/2025 13:35

Twiglets1 · 23/02/2025 13:32

Did she? Can you back that up?
I’m sure I can find other examples but I don’t really have to. I think it might just be you who is denying that anyone at all has lied about their weight to get access to these drugs, celebrity or not. There is huge pressure particularly on young women these days to be slim, especially those in the public eye.

Just google. she even did a podcast on it. At least take time to educate yourself on the drugs or what you’re posting about. She’s very clear she got it from a mate who was a doctor, it was below board, and she took far too much.

https://www.standard.co.uk/showbiz/lottie-moss-hospitalised-ozempic-overdose-b1181628.html

https://www.independent.co.uk/life-style/health-and-families/lottie-moss-ozempic-overdose-hospital-b2611763.html

Glorybox2025 · 23/02/2025 13:35

Twiglets1 · 23/02/2025 13:32

Did she? Can you back that up?
I’m sure I can find other examples but I don’t really have to. I think it might just be you who is denying that anyone at all has lied about their weight to get access to these drugs, celebrity or not. There is huge pressure particularly on young women these days to be slim, especially those in the public eye.

Here ya go

https://www.standard.co.uk/showbiz/lottie-moss-hospitalised-ozempic-overdose-b1181628.html

Moss admitted that a friend helped her obtain the drug, explaining: "It was below board, from a doctor, but it wasn't like you go into a doctor's office and he prescribes it for you

Tulipsandaffodils · 23/02/2025 13:36

Twiglets1 · 23/02/2025 13:35

Simply because Ozempic hasn’t been widely used for weight loss purposes until fairly recently.Now there’s been an explosion of people using it for that reason.

I think as more people use a drug more side effects become known and that is the same for all drugs.

Ok so you’ve nothing to back it up. Fair enough, it’s just your view and I assume you do this for every drug and take no prescription meds unless they have been in use for what, 50 years?

nameey · 23/02/2025 13:39

Thank you for posting this. Scary stuff. There are likely to be more cases in time. I wouldn't be surprised.

OP posts:
Twiglets1 · 23/02/2025 13:39

Glorybox2025 · 23/02/2025 13:35

Here ya go

https://www.standard.co.uk/showbiz/lottie-moss-hospitalised-ozempic-overdose-b1181628.html

Moss admitted that a friend helped her obtain the drug, explaining: "It was below board, from a doctor, but it wasn't like you go into a doctor's office and he prescribes it for you

She said she got it from a doctor?

But she didn’t go to a doctors office so probably her friend told her how to game the system to get it prescribed online.

SilenceInside · 23/02/2025 13:40

The point is that Ms Moss is not an example of someone who easily lied to an online pharmacy to get prescription medication. She knew she shouldn't be getting it and got hold of it illegally "below board" from a friend. It's not an example that makes the point that lots of celebrities are getting it by lying to online pharmacies.

I'm sure that does happen of course, and pharmacies should be doing enough to make that increasingly unlikely. But all of that is irrelevant to the issue of whether there will be new long term dangerous side effects for GLP-1s.