to think more negative effects will come out from Ozempic use?

[nameey]

Just read that the 30 year old singer Avery has been diagnosed with osteoporosis due to Ozempic use. Looks like this could be the start of many conditions coming out.

I know Ozempic is incredibly helpful for a lot of people but losing weight but then having osteoporosis does not seem worth it.

AIBU?

But there is not a debate, it is just some randoms posting nonsense, the op is the prime example. Who would even consider reading about a woman with a signficant eating disorder who developed osteoporosis. Who took the drug against guidelines and not from a doctor, then post a thread saying it was a negative side effect of the drug and more was to come.

thags not a debate, that’s utter nonsense.

I am taking mounjaro, I know it’s not risk free but no medication is risk free.

Over the counter meds that have serious potential risks include:

Paracetamol is high risk because of the small gap between the therapeutic and toxic dose.
Some Antihistamines may increase dementia risk.
Ibuprofen can be hazardous for people with gastric issues or asthma. (I have a form of IBD and my gastroenterologist is ok with me taking MJ but not NSAID).
Aspirin can cause gastric bleeding
Proton Pump Inhibitors can increase osteoporosis risk in the long term, increase the risk of iron deficiency and the risk of food poisoning

Where are the campaigns about those?

How about the people needing liver transplants after taking green tea supplements?

@lettyraines but no actual class action lawsuits as you claimed.

Accuracy matters or you risk undermining your own arguments and credibility.

Osteoporosis is a well knows long term result of eating disorders, which she suffered from.

The case mentioned in the first post is nonsense I agree. But the question posed by @nameey of whether more negative effects will come out in future is one worthy of a debate in my opinion, and some people on this thread are debating it. Many good points have been made on both sides, both that no drugs are ever risk free but also the other side of the coin being that these drugs aren’t suitable for everyone & maybe some people are getting them too easily without enough checks being done that the benefits outweigh the potential risks for that individual.

it is very clear the people posting their concern”concern” have no medical knowledge and don’t even understand how the drugs work, nor have they even bothered to read the trial data. And the pharmacies have been tightened up. However if we look at the black market for drugs across the spectrum it has always existed.

im happy to debate something meaningful. I am not willing to debate with a bunch of people talking made up shite.

and there is no way round the fact it simply looks like jealousy and resentment, that the people posting their made up concerns, really hate the fact we are all getting slim on these meds. Because that’s the impression given when someone makes up shite and posts it.

In fact why not start a thread entitled “if you’re really envious and resentful people can now take drugs and be slim please post your made up concerns here for us to debate amongst the haters , it might make us feel better about ourselves “

@Twiglets1 what's there to debate though? It's going to be like all drugs that are developed, there may be some side effects that are eventually identified that are added to the list of warnings. Or there might not be. It might continue to be used successfully to treat different conditions, or it might not be. How can anyone meaningfully discuss this, without a crystal ball?

All we can say is that at the moment GLP-1s are very safe, given the minimal number of severe adverse reactions compared to the millions that are using them for weight loss or for diabetes.

Well said.

Also, GLP-1 medications aren't new, they've been around a fair while.

How can you debate over potential future side effects that haven't yet been discovered? Do you mean debate whether there might be? Because that's not really a debate. It's clear that there might be some unknown future side effects. Very few WLI users would insist that isn't possible. But there are always potential effects of a drug that might develop in future. What are we debating about that?

I can’t understand what there is to debate, either.

Nobody knows what the future holds. That wouldn’t stop me using a medicine deemed to be safe and effective now.

And as for the people obtaining it when they don’t fit the criteria, pharmacies have had to tighten their controls and new customers have a video call with the pharmacy where you must wear form fitting clothes. This is about as good as it can be at the moment. The NHS have already said it will take years to roll out this drug for weight loss because there simply isn’t the infrastructure needed to support the number of patients.

What? Only class action will do, I see. Again, from your own link:

"On Feb. 2, 2024, Mounjaro lawsuits were among 55 lawsuits targeting its drug class combined in a federal multidistrict litigation in the Eastern District of Pennsylvania."

There are lawsuits against the manufacturers of Mounjaro.

Other lawsuits have been combined into one class action lawsuit, as I understand it, but I am not a legal expert like you. Elsewhere it is referred to as "mass tort lawsuit"...

Ozempic causes serious health issues, class action claims

"Plaintiff Diane Dyess filed the Ozempic side effects class action lawsuit Jan. 31 in Pennsylvania federal court, where it joins an existing multidistrict litigation centered on claims that Novo Nordisk’s glucagon-like peptide-1 receptor agonists (GLP-1 RAs) cause serious injuries, including gastroparesis."

I'd be prepared to bet that those who think a face to face appointment with a doctor should be required for prescribing are also upset how difficult it is to get a doctor's appointment for other issues these days!

I started Mounjaro with obesity class 3 (BMI 43). A face to face appointment to prescribe would have been an utter waste of time. Mounjaro is currently changing my life and health.

Thanks @lettyraines so there is one class action lawsuit against Ozempic, filed 3 weeks ago.

(You have misinterpreted the first quote, there doesn't appear to be any class actions against MJ.)

All cases are in early stages, none have been scheduled and no settlements have been made.

Eli Lilly are richer than Denmark. I'm not surprised that the lawyers have gone after them. Helped by the fact that the FDA has not approved the drugs for weight loss.

Yes there are risks and those risks should be clearly explained and understood, but that doesn't make it a major drugs scandal.

OK so those are regarding the know amd published side effects of the drug. I assume the us has a similar law to the UK in that this info must be provided with the drug so would be surprised if anything came of that.

I think they are mostly for personal injury due to gastroparesis - which was not listed as a potential side-effect until recently, and which is incurable.

"The lawsuit claims Novo Nordisk failed to provide adequate warnings about the risk of gastroparesis and other adverse events allegedly associated with Ozempic, including gastrointestinal injuries, ischemic bowel, necrotizing pancreatitis, gallbladder disease, deep vein thrombosis, micronutrient deficiencies, Wernicke’s encephalopathy and aspiration of gastric contents.

It alleges Novo Nordisk engaged in deceptive and misleading marketing practices to promote Ozempic for weight loss despite the drug only being approved for the treatment of Type 2 diabetes."

Ozempic causes serious health issues, class action claims

I agree with this. What is the debate? What is the question?

I am a scientist so am very happy to argue and research specific questions regarding things like side effects.

The 2 major things that have been raised have been adressed.

The original concern regarding osteoporosis is due to her anorexia rather than the drug.

The blindness study is a concern but exceedingly rare and was predominatly in patients with diabetes ( 8 out of the 9) where the hypoglycemia was a massive leading factor.

If you have Amy other concerns about either the established or emerging potential side effects I quite happy to debate them. Please pose a question.

All the pharmaceuticals you mentioned are to treat symptoms of some variety. The weight loss jabs are an easy fix. People don't seem to mind and dismiss the side effects in the name of vanity.

Is this the kind of measured debate that people want? It's going to is certainly what these threads attract.

OK but this is a know and rare side effect of the drug. It is not novel and was identified at clinical trial level.

When deciding if a drug should be lisenced the regulatory bodies examine the risk of the drug vs the the risk of the disease. This rare side effect in a small proportion of the population is not enough to demish the benifical effect of the drug in terms of treatment for obesity. This is the same for any lisenced drug. All of which have common and serious side effects.

Denial.

Well in the case of the combined pill they aren't treating any symptoms they are giving women control over their reproductive health but are essentially optional. We should ban any drug with the potential for side effects so no pill for you. Just try harder not to get pregnant

What’s denial? You don’t seem to be able to contribute anything of any substance to this thread.

Americans take lawsuits out like we have hot dinners.
There is no debate because we are not psychic. We cannot know nor predict and to do so is unscientific and wanky.
And ‘denial’ of what @Pussycat22 ? You got a side hustle as psychic Pussy ?

It was not on the warning labels until 2023.

"August 2023: First Lawsuit Filed Claiming Gastrointestinal Issues
The first lawsuit is filed alleging severe gastrointestinal injuries from Ozempic and Mounjaro. This lawsuit marked a significant legal challenge related to the side effects of these drugs, leading to summonses issued to Novo Nordisk and Eli Lilly.
September 2023: FDA Updates Warning Labels
The FDA updated the warning labels for Ozempic to include risks of intestinal blockage, obstruction, and ileus, following reports of more than a dozen cases. This update came after 18 cases of ileus were reported to the FDA, with a total of over 8,500 reports of gastrointestinal issues related to drugs like Ozempic and Wegovy. Ileus was mentioned in 33 cases, including two deaths. This labeling update matched the existing warnings for other GLP-1 drugs and receptor agonists."

Lawsuits: Ozempic, other weight loss and diabetes drugs harmful