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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

See all MNHQ comments on this thread

to think more negative effects will come out from Ozempic use?

692 replies

nameey · 22/02/2025 11:12

Just read that the 30 year old singer Avery has been diagnosed with osteoporosis due to Ozempic use. Looks like this could be the start of many conditions coming out.

I know Ozempic is incredibly helpful for a lot of people but losing weight but then having osteoporosis does not seem worth it.

AIBU?

OP posts:
SD1978 · 23/02/2025 08:35

Nope. Anyone who takes part in rapid weight-loss, who does or doesn't need it, there will be side effects. You can't loose huge amounts weekly, and not be causing some long term issues. I'm not against it, but if not done sensibly, there will be side effects. Same if you used shakes, or any VLCD programme.

Tulipsandaffodils · 23/02/2025 08:37

SD1978 · 23/02/2025 08:35

Nope. Anyone who takes part in rapid weight-loss, who does or doesn't need it, there will be side effects. You can't loose huge amounts weekly, and not be causing some long term issues. I'm not against it, but if not done sensibly, there will be side effects. Same if you used shakes, or any VLCD programme.

Sure, everyone knows that, that’s irrelevant of drugs. Looking at the monthly threads, most folks lose up to a couple of pounds a week, some less, some more, average is healthy. So that’s good right.

InfoSecInTheCity · 23/02/2025 08:42

SD1978 · 23/02/2025 08:35

Nope. Anyone who takes part in rapid weight-loss, who does or doesn't need it, there will be side effects. You can't loose huge amounts weekly, and not be causing some long term issues. I'm not against it, but if not done sensibly, there will be side effects. Same if you used shakes, or any VLCD programme.

From my experience and what I see every day on the weightloss threads, most people are losing upto 2 lbs a week, often small gains, staying the same or closer to 1lb a week.

The difference the WLIs make is that it becomes sustainable, so rather than sticking to the diet for a month and then slipping, it is possible to continue for 6 months or a year or 2 years and remain consistent throughout.

Glorybox2025 · 23/02/2025 09:02

SD1978 · 23/02/2025 08:35

Nope. Anyone who takes part in rapid weight-loss, who does or doesn't need it, there will be side effects. You can't loose huge amounts weekly, and not be causing some long term issues. I'm not against it, but if not done sensibly, there will be side effects. Same if you used shakes, or any VLCD programme.

But the numbers of people losing 'huge amounts weekly' are very small. The drug isn't designed to make people lose huge amounts quickly. That's not how it works or how it affects most people. Most people lose 1-2 lbs a week on average. Some people are very sensitive to the drug and lose more at least at the start but as they develop a tolerance to it the rate of loss decreases. WLI are nothing like VLCD.

nameey · 23/02/2025 09:05

Smallsalt · 23/02/2025 00:07

Can somebody start a "concerned" thread for me and others who were prescribed Methotrexate ........ a drug so toxic that you have to have your blood monitored every month. Adverse reactions include ulcerative stomatitis, leukopenia, nausea, and abdominal distress. In addition, infections, malaise, fatigue, chills, fever, Thromboembolic events (including arterial thrombosis, cerebral thrombosis, deep vein thrombosis, retinal vein thrombosis, thrombophlebitis, and pulmonary embolus), pericarditis, pericardial effusion, hypotension, sudden deathToxic epidermal necrolysis, Stevens-Johnson syndrome, exfoliative dermatitis, skin necrosis, and erythema multiforme, erythematous rashes, pruritus, alopecia, skin ulceration, accelerated nodulosis, urticaria, pigmentary changes, ecchymosis, telangiectasia, photosensitivity, acne, furunculosis. Potentially life-threatening hepatotoxicity, pulmonary damage, and myelosuppression.

And that's just the first half page of about 20 pages.
A very toxic drug that's not even the best treatment but it's the go to as its cheap.
Did I mention the birth defects and carcinogenic properties?
Weight loss injections aren't even in the same league.

I want a concern filled thread from all the drug side effect concerned folk because I know they will know all about it because they will be just be as well read on all drugs as they are on Ozempic🙄. I simply can't understand why I haven't seen 200 “Deeply concerned about Methotrexate" threads. Can't figure it out at all........ 🤔

You can start one yourself.

OP posts:
AlphaApple · 23/02/2025 09:09

@Twiglets1 that's my point, plenty of lawsuits but no class action lawsuits.

But as others have pointed out, the litigation landscape in the US is very different. And the FDA is often not fit for purpose.

If Doritos were required to carry the same level of health warnings on them as drugs were there would be class actions against them too.

nameey · 23/02/2025 09:11

Smallsalt · 22/02/2025 23:34

Perhaps if all those "concerned" people were less offensive......

Those who have shown concern or question on this thread have not been offensive or broken talk guidelines and had their posts deleted.

However those who have been offensive towards showing concern or questioning have had their posts deleted by MNHQ - @MzHz and @MiserableMrsMopp

OP posts:
Tulipsandaffodils · 23/02/2025 09:17

This reply has been deleted

Message deleted by MNHQ. Here's a link to our Talk Guidelines.

nameey · 23/02/2025 09:25

This reply has been deleted

Message deleted by MNHQ. Here's a link to our Talk Guidelines.

If you think MN has a low bar, then why continue to post on here? It is the WL injection supporters who have been offensive.

I have never posted under another name about this. You can ask MNHQ,

I an not struggling and neither it is galling for me to see how well people are doing. Take the drugs if it makes you happy. I didn't see where anyone was telling you to stop.

You do sound quite unhappy though if these are the conclusions you jump to. Your defensiveness is telling.

There is nothing for me to deal with. I made a post about a singer. It is not that deep.

OP posts:
Caffeineneedednow · 23/02/2025 09:25

lettyraines · 23/02/2025 07:42

I'm not going to argue the toss, point by point, however, just from the wiki entry I linked:

"Fenfluramine was marketed by American Home Products (later known as Wyeth) as Pondimin, but was shown to cause potentially fatal pulmonary hypertension and heart valve problems, which eventually led to its withdrawal in 1997 and legal damages of over $13 billion."

Fenluramine had a weaker effect on its own. It was available from the 1970s to late 90s. Fen-Phen was a combo drug that was considered a wonder drug for weightloss in the nineties, until the reports of heart problems started flowing in, and a number of deaths from heart problems in users occurred. It was also viewed as useful for drug addiction... Wyeth set aside $21.1 billion (U.S.) to cover the cost of the lawsuits.

Given there are already class action lawsuits in the States, involving Ozempic, Rybelsus, Wegovy, Trulicity, and Mounjaro, from people claiming they weren't properly informed of the risks, I really don't think you can say "the risks of this class of drugs are minimal".

Please link the class action suits.

Ad a pp said I belive these are some who failed to be aware of the known side effects of the drug. This information is in the information leaflet and as others have said listing these is a legal requirement of advertising the drug in the US.

Yes this drug has side effects no one is disputing that. Most are mild and temporary ( usually gi related). Perhaps minimal was the wrong word but the side effect profilenjs no more dangerous then that of say the combined pill. However in the many years I have been on mumsnet I have never seen a thread about the potential dangers in the way the conversations regarding glp1 agonists are.

Hers is a the risks associated with the pill

https://www.drugs.com/article/birthcontrolpill-risks-benefits.html#:~:text=Combination%20pills%20that%20contain%20both,estrogen%20due%20to%20medical%20reasons.

To be clear I am not saying people shouldt take the pill but rather all drugs carry risk. However a drug that has been in the population for 30 years gives us a good data set of side effects. Which for this drug are small compared to the well established risks of obesity.

The specific concern of the OP regarding 1. The osteoporosis and 2. The blindness study have been discussed. No one is ignoring them they are saying 1 was due to a separate disease and 2 is so exceedingly rare that the risks are minimal.

On the blindness I would add that 8 / 9 affected suffered from diabetes which the study acknowledges was a contributing factor.

Smallsalt · 23/02/2025 09:26

nameey · 23/02/2025 09:05

You can start one yourself.

I just thought people worried with drug side effects might like to. Because you know...... "concerned".

Oh...... you mean it's just Ozempic that worries you to this extent. Riiight.

janeavrilavril · 23/02/2025 09:29

Matrixremooted · 22/02/2025 11:54

I agree to an extent OP and it will be interesting to see what the data says over the next few years, but those who are taking WLI do not want to hear anything negative at all about them. As far as they’re concerned they are the golden panacea for their weight issues.

It is like a cult, it is apparent in many responses here. Nothing slightly negative can be put forward.

Glorybox2025 · 23/02/2025 09:29

janeavrilavril · 23/02/2025 09:29

It is like a cult, it is apparent in many responses here. Nothing slightly negative can be put forward.

I mean, that's not even slightly evidenced by this thread. It's something you've made up and decided to believe.

SilenceInside · 23/02/2025 09:34

@janeavrilavril if people put forward negative things that are untrue and without evidence then of course people will challenge those statements. The kind of negative nonsense that's all over this thread gets repeated each time one of these "concerned" posters starts a thread about it. Usually after another sensationalist Mail article.

Tulipsandaffodils · 23/02/2025 09:36

nameey · 23/02/2025 09:25

If you think MN has a low bar, then why continue to post on here? It is the WL injection supporters who have been offensive.

I have never posted under another name about this. You can ask MNHQ,

I an not struggling and neither it is galling for me to see how well people are doing. Take the drugs if it makes you happy. I didn't see where anyone was telling you to stop.

You do sound quite unhappy though if these are the conclusions you jump to. Your defensiveness is telling.

There is nothing for me to deal with. I made a post about a singer. It is not that deep.

Um I was responding to you. Unless you’re Justine, then I’m fairly sure it was obvious I wasn’t saying mnhq had a low bar. I said you did,😂

and I’m afraid I’m sorry to disappoint again, I’m not unhappy. I’m actually delighted, I cannot believe they cured obesity and I feel so lucky I’ve been able to access the medication and it has worked so well for me. I love being a healthy weight, having loads of energy, that my health markers are improved. And I love i have refound my vanity and able to wear some gorgeous clothes.

the unhappy one is clearly you, who is driven to start daft threads, and then posting sullen and rather batshit responses.

and yes, taking the drugs do make me happy, or the effects of them make me happy . I will continue to take them to maintain. I feel so lucky to be able to do so. I fully intend to continue to be a slim and healthy weight and not have to worry about deprivation or managing the scales again.

but you can crack on with your concern and mad threads. Although it doesn’t seem to be making you happy. Poor you.

Tulipsandaffodils · 23/02/2025 09:37

janeavrilavril · 23/02/2025 09:29

It is like a cult, it is apparent in many responses here. Nothing slightly negative can be put forward.

We welcome anything negative, but it needs to be factual not nonsense. People will challenge bullshit.

Smallsalt · 23/02/2025 09:39

nameey · 23/02/2025 09:11

Those who have shown concern or question on this thread have not been offensive or broken talk guidelines and had their posts deleted.

However those who have been offensive towards showing concern or questioning have had their posts deleted by MNHQ - @MzHz and @MiserableMrsMopp

Offensive does not necessarily mean writing abusive things.
It means that people are constantly "going on the offensive" with constant anti GLP comments based on their own assumptions and bias. Which in return makes people who use the drug legitimately and safely and with great health benefitd become very defensive. Words have different meanings and context.

wombat15 · 23/02/2025 09:42

Like any drug it will have adverse effects for some people. Therefore like any drug only use if the likely benefits outweigh the likely risk.

Twiglets1 · 23/02/2025 09:44

Glorybox2025 · 23/02/2025 09:29

I mean, that's not even slightly evidenced by this thread. It's something you've made up and decided to believe.

I do think some of the responses on this thread do show anger at the merest suggestion that more negative impacts of taking Ozempic/Wegovy/Mounjaro could emerge over time.

No one on this thread is denying the many positives of taking weight loss drugs for people that are obese. But that doesn’t mean there aren’t potentially negatives too. Obviously it is a fairly recent thing that so many people in society are now taking these type of drugs for weight loss rather than diabetes. So I think the debate about whether they should be easily available to anyone that wants them or whether they should be prescribed by doctors face to face for example so a proper risk versus benefit assessment can be done, is a valid one.

Smallsalt · 23/02/2025 09:45

janeavrilavril · 23/02/2025 09:29

It is like a cult, it is apparent in many responses here. Nothing slightly negative can be put forward.

Or, if you don't approve of them them, think they are dangerous don't take them. Simple.

Tulipsandaffodils · 23/02/2025 09:45

Twiglets1 · 23/02/2025 09:44

I do think some of the responses on this thread do show anger at the merest suggestion that more negative impacts of taking Ozempic/Wegovy/Mounjaro could emerge over time.

No one on this thread is denying the many positives of taking weight loss drugs for people that are obese. But that doesn’t mean there aren’t potentially negatives too. Obviously it is a fairly recent thing that so many people in society are now taking these type of drugs for weight loss rather than diabetes. So I think the debate about whether they should be easily available to anyone that wants them or whether they should be prescribed by doctors face to face for example so a proper risk versus benefit assessment can be done, is a valid one.

And I read it that the people posting their concern and these negative impacts which they have no evidence behind are simply resentful and jealous.

i guess we all read something different into responses right.

Tulipsandaffodils · 23/02/2025 09:46

Twiglets1 · 23/02/2025 09:44

I do think some of the responses on this thread do show anger at the merest suggestion that more negative impacts of taking Ozempic/Wegovy/Mounjaro could emerge over time.

No one on this thread is denying the many positives of taking weight loss drugs for people that are obese. But that doesn’t mean there aren’t potentially negatives too. Obviously it is a fairly recent thing that so many people in society are now taking these type of drugs for weight loss rather than diabetes. So I think the debate about whether they should be easily available to anyone that wants them or whether they should be prescribed by doctors face to face for example so a proper risk versus benefit assessment can be done, is a valid one.

And as no one on here is the mhra then it’s not a debate, it’s just some randoms posting made up shit.

Twiglets1 · 23/02/2025 09:49

Tulipsandaffodils · 23/02/2025 09:45

And I read it that the people posting their concern and these negative impacts which they have no evidence behind are simply resentful and jealous.

i guess we all read something different into responses right.

We probably do all interpret responses differently. But unless someone is actually being rude then I think it’s interesting to debate topical issues ( & Ozempic etc is very much in the media) without being challenged on “what’s it to you? Thanks for your fake concern” type of replies.

lettyraines · 23/02/2025 09:51

AlphaApple · 23/02/2025 08:17

@lettyraines can you link to the class action lawsuits against MJ? This link suggests there aren't any. www.drugwatch.com/legal/mounjaro-lawsuit/

There's this:

"These lawsuits focus on serious stomach and gastrointestinal problems linked to medications known as GLP-1 receptor agonists, GLP-1 drugs, or diabetes medications. This group includes Ozempic, Wegovy, Mounjaro, Trulicity, Saxenda, and Rybelsus. People filing the lawsuits claim that these drugs didn’t have proper warnings."

Understanding the GLP-1 Drugs Lawsuits: Severe Stomach Side Effects from Ozempic, Trulicity, Mounjaro, and Other Diabetes Medications

And this:

"More than five dozen lawsuits accuse Novo Nordisk or Eli Lilly of failing to notify patients about the side effects of their popular diabetes or weight loss drugs. Those drugs include Novo Nordisk's Ozempic, Wegovy and Rybelsus, and Eli Lilly's Trulicity and Mounjaro. These personal injury cases have been centralized under a federal judge in Philadelphia because they share common elements involving the same class of drugs.

Among the more than five dozen lawsuits thus far, Novo Nordisk, maker of Ozempic and Wegovy, faces the most suits. However, the attorneys expect the case will eventually include thousands of others who say they were harmed."

Lawsuits: Ozempic, other weight loss and diabetes drugs harmful

Edit to add: also, your own link goes into great detail about the lawsuits against Mounjaro!

KrankyKumquat · 23/02/2025 09:51

'It is like a cult'

And it's using language like this that pisses people off. It's inaccurate and deliberately inflammatory and people who say things like this know exactly what they're doing. They're not interested in learning about the experiences of people who use WLIs or concerned about the side effects or even truely bothered about the impact of obesity on individuals or society. It's just a game to them, another way of bullying fat people, a pathetic attempt to bolster their own damaged self-esteem.

I wonder if some of these same people will, one day in the future, be fighting to be prescribed glps due to their heart or kidney disease, neurodegenerative condition, T2D, addictions, sleep apnea, or high risk of stroke. Bet they won't be clutching their pearls and spreading misinformation then.