@IBlameTheDog it sounds like histamine to me. More oestrogen can make that worse. Is it utrogestan capsules you are on? Body identical progesterone is supposed to help with histamine. I think if you are on anything higher than a 50 patch/2 pumps gel the guidelines from the British Menopause Society are to be on 200 mg progesterone a night continuously (or 300 cyclically).
Look at mastcell360 for a list of low histamine foods and stay away from the worst culprits. No processed food (I'd include anything in tins and cans in this). No fermented foods (yoghurt, kim chi etc), no alcohol, no aubergine, spinach, tomato, dried fruit, aged meat, smoked anything, bacon, ham, fish. Fresh chicken is best. Onions, broccoli, apples and blueberries for fruit and veg all contain quercetin so can actually help, but most fresh fruit and veg are ok. Citrus can be aggravating but it can all be quite personal too. Best cheeses are soft fresh cheeses, mozzarella and ricotta, that type stuff. Basically the older the food the more histamine it has. Not all probiotics are suitable, and I dont know which ones are, that could be personal too. Try a quercetin supplement, and a DAO enzyme supplement if you can get it. Tea blocks DAO enzyme or something like that, can't remember.
A short period of time should tell you if you're on the right track. Do you think you got worse since upping the oestrogen? Diet is restrictive but if you do it properly for a short time you should get answers quickly and can start adding things back in. Also a little bit of something might make no difference to you, so a few leaves of spinach might be OK but a whole spinach salad not OK. People talk about histamine as a bucket, fine to a certain level but can overflow and cause problems. Also if your mast cells are overreacting they can calm down on a low histamine diet and not overreact to every little thing when you start to add food back in.
Apparently anti histamines can make your body think it needs more histamine so it ends up producing more, so they can help short term but not long term. They don't actually clear histamine from the body, they just block cells from receiving it or something like that.