There's always a long stream of MNers insisting that because they have normal, predictable, optimally-functioning bodies, everyone must be the same as them. CICO works as expected for them, so it must do for everyone else. It's as though hormones, medications and illnesses never make bodies malfunction ... which is a strange attitude.
There are things like this:
Lipodystrophy syndromes are a group of genetic or acquired disorders in which the body is unable to produce and maintain healthy fat tissue.
Cachexia is a complex syndrome associated with an underlying illness, causing ongoing muscle loss that is not entirely reversed with nutritional supplementation. A range of diseases can cause cachexia, most commonly cancer, congestive heart failure, chronic obstructive pulmonary disease, chronic kidney disease, and AIDS.
Genetic factors are not trivial, as mentioned by @athingofbeauty just now, and neither are hormones. It's not only fertility-related hormonal changes, although those are cataclysmic for many of us, but also things like pituitary, adrenal, thyroid, pancreatic hormones (and the rest). Our hormonal profile's a deeply complex, interdependent messaging system. One change affects the others and women's change all the time.
It's absurd to protest that a dynamic, living biochemical system is the same as a combustion engine.
In the same way, medications don't just make you more or less hungry - many of them are prescribed for their far-reaching effects on our biochemistry and their ability to activate or block hormone receptors throughout the body. Medicine can't yet target them to have one effect but no others - that might not even be wise - so, of course, some can make our bodies pile on weight or lose it.
I can't be bothered to make a list of diseases & conditions known to make people's bodies accumulate flesh so intensively that they couldn't diet it away without suffering malnutrition, or refuse to accumulate it so that additional food causes liver failure.
Of course some version of CICO will work for most people at least some of the time, and of course it's worth experimenting to find out what works best for you. It's just massively annoying when people flatly deny that it will not always work for everyone. There's plenty of evidence that it's way more involved than so-called experts want to believe.
FWIW my BMI is 25, up from 21 since starting antidepressants and, simultaneously, menopause. I may have just escaped "overweight" but I can see I've got a lot more visceral fat than I had at the same weight in my thirties. This appears to be my "set point" nowadays - it might go back down if I stopped the antidepressants but, then, I'd be stuffing sugar in my face to stave off the suicidal feelings! I'll take the meds and the doughy midsection 😏
Great post, @athingofbeauty.