It depends what's important to you: happiness now, or the likely event of the problems of a big age gap later? Are you willing to gamble?
Are you particularly mature for your age? The majority of 22 year olds I know would be unsuitable for the 37 year olds I know because they are still very 'young' - not a lot of life experience etc. The 37 year olds are also established in their careers and financially and in terms of housing, whereas the 22 year olds aren't, and the 37 year olds would be unwilling to go through the relative instability of a partner who is still getting set up in life.
It's not a red flag for me per se, but I'd certainly be wondering why any 37 year old friends of mine wanted to date a 22 year old. In my experience (and very much acknowledging this isn't always the case!) it's usually to do with wanting to feel younger, or that women their own age won't put up with their shit.
And, on the flip side - the difference between 35 and 50 can be huge. I know 55 year olds retiring (rich ones, but still). I know 35 year olds not having decided on their career yet. The difference between 45 and 60 - with you having maybe 20 years left to work, and him winding down for retirement - is going to feel like a gulf unless you can afford to retire very young with him.
Do you want children? Does he? Are you financially compatible, do you have the same potential earning power as him? Is there a big power imbalance between you aside from the age (which is a big one on its own)?
If either of you were a friend of mine, I'd be concerned tbh. That doesn't mean it can't work, but there are a lot of areas of potential problems.