[quote LookingGlassMilk]**@LookingGlassMilk thanks for linking. I don't understand much of (my science A levels were a while back) but looks like this is mostly for "in frog, mouse and zebrafish embryos"
Here is one on macaques: academic.oup.com/cercor/article/17/12/2961/384220
Obviously there are ethical issues with doing a similar experiment on humans, but the same biological mechanisms apply.[/quote]
I agree with you that excess alcohol even during early pregnancy can produce FASD. However the levels of alcohol they were force-feeding the monkeys exceed what the average woman would drink on a regular basis.
From my reading they were saying the blood alcohol level of the macaques was around 231mg/dl. That's equivalent to a blood alcohol level of 0.231% (www.wikidoc.org/index.php/Blood_alcohol_content)
That's the equivalent of necking 4 glasses (150ml each) of wine in a single swig (www.alcohol.org/bac-calculator/)
I don't know a single woman who would swig 2/3rds of a bottle of wine in a single dose with no food...and do it regularly for 6-24 weeks!
That's my problem with these studies - they tend to translate poorly to actual real-world scenarios.
But I agree with you that binge drinking regularly in early pregnancy is a terrible idea. I'm just not sure the sort of person who would drink the amounts cited above would care what the WHO had to say about the matter (or even exists)