My comment wasn’t so much about her not marrying someone as academic (i’m married to someone with barely any o’levels) but their pathways in life are so clearly different. One would have to significantly compromise- ron’s a homebody like his parents, that’s not Hermione’s life choice. She’s off to rule the world, and has the potential to do so.
I think that's why (once he's grown up) Ron's a good partner for Hermione...Hermione can get on with changing the ministry and Ron is the "steady" partner in the background who makes sure she relaxes occassionally/lets the kids have fun when she would probably get a bit "tiger mum".
Ron's mum is probably a big "pro" too...kids need a last minute dragon costume/school bake sale etc. and Molly would be on it.