My DH has worked from home for about 14years, he only ever works Mon-Fri, there has only been once when he has to work a weekend and it was horrendous for all of us, so it is never been repeated.
We have 3 children, 21, 14, 12 so all of them have been brought up without Dad being at home, but he has always been there for them. They have a normal parent-child relationship, they have not been affected by him spending time away from the home.
We have a normal husband-wife relationship, its bloody hard sometimes, sometimes its a blessing, but we have got through not being together all week because we are important to each other.
The DCs are now older, him working away is easier as I don't need the extra pair of hands, but its also harder because I spend more time with my own company and I find myself boring sometimes. But we all get through the week because we know that we have the weekends together, the time we have then is of better quality than if he lived at home.
Being separated during the week is not all doom and gloom, it can and does work for a lot of couples, but you have to work at it.