I actually like the fact that Sheldon has Amy.
I went to Uni which had mainly engineering/aviation based subjects, and had 1 female for every 12 males.
I met a lot of characters that fit with the personalities of the 4 lead guys. You used to wonder if they would ever meet anyone and settle down, especially the Sheldon types. Chat up lines were tragic, they had never really paid attention to girls in school, or found it really difficult to pluck up the courage to do so.
However most, if not all, in my year did form relationships and it was interesting to observe the definition of relationship for different people, and the rules and expression of attraction for different people.
Not everyone wants or has a typical text book romance and love comes in many different forms.
Meeting up at reunions years later it is great to be introduced to wives and partners, who could look beyond the abundance of polyester Christmas jumpers and see the amazing personalities beneath.
I ended up with the Howard type character!