@kittensinthekitchen What you say about drugs and ADHD is spot on.
I've never used recreational drugs except for once and once only when I was in my early twenties. I took an ecstasy pill, same ones as my friends did. They were all high as bloody kites. Nothing happened to me, I was bored so I just went home. Caffeine doesn't keep me awake or affect me at all either.
I'd thought no more about it until I was diagnosed with ADHD (and autism) and started stimulant medication recently (nearly twenty years later). I am not even hyperactive type, I'm inattentive/hyperactive combined. The medication is an amphetamine.
In someone without ADHD, you've guessed it, it would make you high, and well, 'speedy'. In me, it calms my busy brain. I have clarity and focus. It stops me binge eating food for a dopamine hit. No one else would even noticed I'd taken it.
Johnny Depp has ADHD. It's more than likely he would react very differently to recreational drugs than someone without it.
I am no fan of his, his behaviour if he didn't do all of those physical and sexual things she said is still foul (and abusive) and if he did do them then he's monstrous and needs locking up for a long time. I'm undecided on which it is.