@honeyroar sorry to hear about your job 
Personally I'd say a nice simple template, no fancy borders or mixing fonts. A short 'summary' at the top tailored to each individual job, drawing out your best/most impressive selling points and experience.
Then list your work experience in chronological order (most recent first) with a short, easy to read, jargon free explanation of what each role was and your key duties and/or achievements in each job. If you did different jobs within the same company then you can either split them out or group together, whichever makes more sense. Feel free to summarise or group older jobs together e.g '1980-1990 various sales roles in the pharmacuetical industry' or whatever, and don't feel obliged to list the Saturday job you had at college unless it's relevant (I know some online guides insist the work history must be 'full and complete' but personally I think that's nonsense). Include a short explanation of any gaps e.g. 2005-2007 undertaking a full time degree, 2010-2012 career break to raise children or similar.
Then a section with your qualifications, education history and any relevant training or certification (you don't need to include every training course you've ever been on but do make sure to include any they have said are relevant in the JD or advert). Then if you have space, a brief 'hobbies and interests' section and list your referees, or say 'references available on request'.
Make sure you always carefully tailor your cover letter or supporting statement in particular to the job, give specific examples of how you can demonstrate the relevant competencies and skills (so rather than 'I am competent with payroll software' say 'I have used X, Y and Z software packages in my roles as Administrator in A company and Payroll Officer in B company'), and why you would be a good fit for the particular role. Do not simply copy and paste from previous applications, as you are liable to go straight in the bin if you write (as a PP said) 'I have always wanted to work for the NHS' when it's a civil service job or vice versa!
Very, very thoroughly proof read both your CV and supporting letter before sending, ideally get someone else to cast a eye over it too. Avoid acronyms unless they are standard in your industry and watch your jargon and/or overly flowery, gushy language. Try and keep everything as clear and business like as possible!
Good luck!