50 this October.
Negatives - everything takes longer to heal, the flip side being I am vastly more careful about lifting heavy things alone. Eyesight has always been crap, but I reckon next time I have a test I'll need varifocals.
Positive - I don't rely on being fit simply through my everyday life (active job) but have taken up regular swimming, cycling & just starting running. That plus taking more care with hair, clothes etc means I look better than I did at 40 I'd say (older, obviously, but more 'cared for' IYKWIM). Having a teen rather than a small child means I have more time & money to achieve all these things!
I split up with H after 25 years together, it was a painful few years in the happening and the recovery. But I spent a year being 'actively single' and learning how to be a grown up on my own, which was great, then had a good time figuring out how to date again & remembering the joys of casual sex. Now just over a year into a relationship with a lovely, kind and gentle man I would never have dated in my 20s, but who feels absolutely right for me now.
Elderly parents are a big part of my life, as for most of my friends, and that along with other friends' serious illness & disabilities have made me much more aware of my own mortality. That's not a good thing or a bad thing I'd say, but it makes me live my life with more care I hope.
The best thing is I think overall I am - or at least try my hardest to be - a calmer and nicer person than I was 10 years ago.