Yep, the last half hour of Beaches gets me every time.
Meet Joe Black at various places which is mostly due to Thomas Newman's beautiful score
Masquerade (Rob Lowe/Meg Tilly) particularly at the end but also has a beautiful score. Currently on Netflix if interested
On The Beach (Gregory Peck/Ava Gardner) - oh the nobility and bravery shown in the face of impending doom. Book is more devastating though.
Out Of Africa - gorgeous score and a beautiful retelling of Karen Blixen's story of disaster followed by disaster punctuated by her finding love and then losing it again. I'm teary all the way through.
Dances With Wolves - again beautiful score and heart wrenching story
Shirley Valentine - particularly in the bit where she asks us the audience "why do we get so much life when we don't do anything with it?" (or words to that effect)
The Ballad of Little Jo (Suzy Amis) - rare to find film from 1993 - heart wrenching at the end when her friend realises the truth of her life
The Remains of the Day - all that pent up life just wasted. Anthony Hopkins expression at the end is a bit like Shirley's question above but he doesn't ask it - he just puts his 'duty' stiff upper lip back on.
My most blubbiest film is Untamed Heart (Christian Slater/ Marisa Tomei). On first viewing I sat speechlessly sobbing at the end and subsequently start crying from the opening credits until the very end EVERY time I've watched it since. I only watch this one when I am on my own at home and I know that no ones coming home for a few hours!