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AMA

I’ve lost 7 stone on Mounjaro and plan to be on it for life. AMA

204 replies

LifeOfAShowGirl · 13/08/2025 16:06

:)

OP posts:
LifeOfAShowGirl · 13/08/2025 16:57

TheRealGoose · 13/08/2025 16:56

Well done op. It’s wonderful isn’t it! I’ve lost 6 and a half stone, now a size 8-10 at 5ft 6.5, work out six days a week, have visible muscle and tone. I’m mid 50s. My sleep apnea is cured, and I’m off the blood pressure meds,

I’m now in maintenance, and will stay on the lowest therapeutic dose, which is 5mg long term or till something better comes along. I feel so much healthier, I sleep 8 hours a night, wake up in a great mood, and vainly am for the first time ever very happy with my weight and appearance. I also ate my protein, and took biotin daily and my hair has never been better. My blood test results are now all normal.

i tell anyone who asks how I did it, and the healthy results are staring them in the face, could I try to go it alone, sure but I know it will come back on ultimately and I don’t want to live my life with that daily struggle,I also want the other therapeutic benefits of the drugs ie blood sugar management, insulin management and of course the new findings cardio vascular, liver and kidney health, as well as potentially, now in trials, preventing certain cancers and even dementia.

studies are now also showing it has an anti ageing effect on our internal organs, something to do with t cell production and the anti inflammatory effects, which doesn’t just slow ageing of our internal organs but in some people reversing it.

and of course contrary to the media scare stories, the instances of pancreatitis and gallstones is actually significantly reduced in people who take it, and its weight gain or rapid weight loss that causes that, so as long as you lose at a healthy rate, say 2lbs a week, then you limit risk from losing weight. Thyroid cancer was seen in mice in early trials but they tweaked it and not since, but it still goes on the box. They think over 50 million people now on the drugs globally as every developed country has approved, and thr WHO will approve next month and likely put it on their list of essential medication, which means every country with a functioning health care system needs to offer it to their population.

I just wish it was available to everyone in the right dose, but for many it is affordable, you’re only on the high doses for a short period, the lower doses really cost 20 odd quid a week if you take the 5fh dose, and that’s offset often i. the reduction is grocery and alcohol bill. We will get there though, as more drugs enter the arena.

good luck on the rest of your journey, and then maintenance, and I hope you look and feel wonderful x

Congratulations!!! I love looking at the news of the new drugs that are in play. I really think that the options for maintenance will just get better and better.

OP posts:
TitaniasAss · 13/08/2025 16:58

Congratulations on your weight loss.

What will you do if there comes a point that you just can't afford to stay on it? Do you think your mindset has changed enough for you to eat more healthy, should you have to do without it?

Periperi2025 · 13/08/2025 16:58

captureitrememberit · 13/08/2025 16:48

Btw- love the username 😉🧡

I am considering MJ. I am mostly concerned about feeling sick/ nauseous all the time. I work nights so can’t be feeling rubbish. Has this been your experience? X

I suffered from hyperemesis when pregnant with my dd, and the anxiety around it was holding me back from starting mounjaro as recommended by my endocrinologist. I started myself on 1.25mg, just to test my reaction to it.

6 weeks on I'm still on 1.25mg, with minimal side effects and 21lb down, and no intention of increasing until I'm averaging less than 2lb a week loss over the previous 4 weeks (as that is plenty fast enough).

I'd recommend trying 1.25mg just to see what it feels like, rather than avoiding it for the sake of a side effect you might not even experience.

LifeOfAShowGirl · 13/08/2025 16:59

TitaniasAss · 13/08/2025 16:58

Congratulations on your weight loss.

What will you do if there comes a point that you just can't afford to stay on it? Do you think your mindset has changed enough for you to eat more healthy, should you have to do without it?

i think being unable to afford it is unlikely for me, but if it really came to it I’d wean myself off. But like I say, I can’t really see that happening for me.

OP posts:
LifeOfAShowGirl · 13/08/2025 17:00

LifeOfAShowGirl · 13/08/2025 16:59

i think being unable to afford it is unlikely for me, but if it really came to it I’d wean myself off. But like I say, I can’t really see that happening for me.

Just to add to this - it’s worth remembering that Eli lily’s patent for this drug is ending in the next few years. It means that many other manufacturers will be able to make it - and the price will therefore reduce.

OP posts:
HotTiredDog · 13/08/2025 17:04

“The long term effects of obesity are by far worse than any potential side effects.”
Sadly not; my BMI is over 35 & mostly due to a cocktail of meds over 15 years. I would love to take Mounjaro / Ozrmpic etc. Sadly the effect on gut motility would change absorption rates & this would very likely kill me within 3-6 months. I am, as you’d imagine, rather miffed about this.
However that doesn’t stop me from being so impressed by & happy for people like the OP here - well done @LifeOfAShowGirl keep going!

Periperi2025 · 13/08/2025 17:06

LifeOfAShowGirl · 13/08/2025 16:59

i think being unable to afford it is unlikely for me, but if it really came to it I’d wean myself off. But like I say, I can’t really see that happening for me.

Also, to add to the concern about affording it long term.

There is a pill version that has been through trials and is in the process of licensing currently (i think), it is less effective, bit still impressive, and will be significantly cheaper as it is more stable (no refrigerating) and doesn't require the fancy dosing syringe.

I think it is likely that many people will step across onto this oral form for maintenance in the future.

LifeOfAShowGirl · 13/08/2025 17:08

Periperi2025 · 13/08/2025 17:06

Also, to add to the concern about affording it long term.

There is a pill version that has been through trials and is in the process of licensing currently (i think), it is less effective, bit still impressive, and will be significantly cheaper as it is more stable (no refrigerating) and doesn't require the fancy dosing syringe.

I think it is likely that many people will step across onto this oral form for maintenance in the future.

Yes, I’ve seen about the pill. That, again, will have unbranded versions available at some point in the future. There’s also apparently monthly and even yearly infections that are in the works. These drugs are just the beginning, which I find to be incredibly exciting!

OP posts:
TheRealGoose · 13/08/2025 17:09

LifeOfAShowGirl · 13/08/2025 17:00

Just to add to this - it’s worth remembering that Eli lily’s patent for this drug is ending in the next few years. It means that many other manufacturers will be able to make it - and the price will therefore reduce.

They also have a massive law suit on their hand from another behemoth. The case is there was no art in what el Lilly did. They didn’t create it, it was created in the early 1970s and been in use for decades, they simply packaged, marketed and got it approved for weight loss. So the lawsuit says their patent for the active ingredients is invalid. If the challenger wins, we will see generic versions quickly and of course wegovy and ozempic main patents expire next year with multiple generic versions ready to go. On top of this there is now 8 new drugs in final testing, inc obvs the pill version from el Lilly.

LifeOfAShowGirl · 13/08/2025 17:10

TheRealGoose · 13/08/2025 17:09

They also have a massive law suit on their hand from another behemoth. The case is there was no art in what el Lilly did. They didn’t create it, it was created in the early 1970s and been in use for decades, they simply packaged, marketed and got it approved for weight loss. So the lawsuit says their patent for the active ingredients is invalid. If the challenger wins, we will see generic versions quickly and of course wegovy and ozempic main patents expire next year with multiple generic versions ready to go. On top of this there is now 8 new drugs in final testing, inc obvs the pill version from el Lilly.

Oh interesting!! I asked ChatGPT about current trials, and there seem to be a huge amount. It’s a very exciting time to be fat and a jabber!

OP posts:
PopstarPoppy · 13/08/2025 17:10

LifeOfAShowGirl · 13/08/2025 16:52

These drugs have been used for decades.

They’ve been around for decades, but they’ve not been that widely used until the past 10 years and even the people who have been on the drugs ‘for decades’ have not been on them for a lifetime. They are currently the subject of huge amounts of research and they have been linked to a number of health issues. It’s your choice to ignore those if you want, but they do exist, and doctors/pharmacists ought to take them into account when prescribing.

LifeOfAShowGirl · 13/08/2025 17:11

PopstarPoppy · 13/08/2025 17:10

They’ve been around for decades, but they’ve not been that widely used until the past 10 years and even the people who have been on the drugs ‘for decades’ have not been on them for a lifetime. They are currently the subject of huge amounts of research and they have been linked to a number of health issues. It’s your choice to ignore those if you want, but they do exist, and doctors/pharmacists ought to take them into account when prescribing.

Edited

Can you provide links to the studies showing the long term health effects?

OP posts:
Disturbia81 · 13/08/2025 17:15

LifeOfAShowGirl · 13/08/2025 16:22

I’ve found the opposite! I’m so much happier than I was before I started. I think because I’ve lost so much weight, I’m eating better and I’m moving more, I’m a lot happier. I’m probably the happiest I’ve ever been

That’s fantastic ♥️

PopstarPoppy · 13/08/2025 17:16

LifeOfAShowGirl · 13/08/2025 17:11

Can you provide links to the studies showing the long term health effects?

Here’s one, published in January:

“Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are increasingly being used to treat diabetes and obesity. However, their effectiveness and risks have not yet been systematically evaluated in a comprehensive set of possible health outcomes.”

“There was an increased risk of gastrointestinal disorders, hypotension, syncope, arthritic disorders, nephrolithiasis, interstitial nephritis and drug-induced pancreatitis associated with GLP-1RA use compared to usual care.”

https://www.nature.com/articles/s41591-024-03412-w

sorrynotathome · 13/08/2025 17:18

The drugs have been widely used globally and very widely researched. Very few modern medicines have been used "for a lifetime" anyway. For those anticipating big price drops after patent expiry - think again. These medicines are difficult and expensive to produce - the first GLP-1 patents expired years ago but there were not lots of competitors champing at the bit to make copies.

LifeOfAShowGirl · 13/08/2025 17:18

PopstarPoppy · 13/08/2025 17:16

Here’s one, published in January:

“Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are increasingly being used to treat diabetes and obesity. However, their effectiveness and risks have not yet been systematically evaluated in a comprehensive set of possible health outcomes.”

“There was an increased risk of gastrointestinal disorders, hypotension, syncope, arthritic disorders, nephrolithiasis, interstitial nephritis and drug-induced pancreatitis associated with GLP-1RA use compared to usual care.”

https://www.nature.com/articles/s41591-024-03412-w

And yet the overwhelming consensus is that these drugs are much, much better than being obese. I’ve come into contact with multiple health professionals over the last year who have all confirmed I’m doing the right thing. My dad’s cardiologist has a “special interest” in them (his words) and he thinks they’re wonderful. Yes, there are risks. But the risks to the average person of being obese are much worse.

OP posts:
Pamspeople · 13/08/2025 17:20

I'm curious about how people deal with the emotions that they would previously have numbed with food. It may not be part of your relationship with food pre weight loss, so you might not be able to answer, but I often wonder if the emotional hunger fades as well

LifeOfAShowGirl · 13/08/2025 17:21

Pamspeople · 13/08/2025 17:20

I'm curious about how people deal with the emotions that they would previously have numbed with food. It may not be part of your relationship with food pre weight loss, so you might not be able to answer, but I often wonder if the emotional hunger fades as well

To a degree I’ve found it has. I turned to running and the gym to help quiet my mind.

OP posts:
Pinkpelicanwinstherace · 13/08/2025 17:23

I've lost 7 and half stone on it and have another 5 to go.
But it saved me taking NHS resources on WLS.
So it's all good

LifeOfAShowGirl · 13/08/2025 17:23

Pinkpelicanwinstherace · 13/08/2025 17:23

I've lost 7 and half stone on it and have another 5 to go.
But it saved me taking NHS resources on WLS.
So it's all good

Congratulations!!! I was at the point where I was going to go for WLS, I’m so happy I didn’t

OP posts:
Pinkpelicanwinstherace · 13/08/2025 17:25

LifeOfAShowGirl · 13/08/2025 17:23

Congratulations!!! I was at the point where I was going to go for WLS, I’m so happy I didn’t

Yes me to
I was due op in February
I only went on injections so I didn't have to have surgery
Absolutely terrified what happens when I come it
But I'm 5 stone away from thinking about that yet
Congratulations to you for your loss

PopstarPoppy · 13/08/2025 17:28

LifeOfAShowGirl · 13/08/2025 17:18

And yet the overwhelming consensus is that these drugs are much, much better than being obese. I’ve come into contact with multiple health professionals over the last year who have all confirmed I’m doing the right thing. My dad’s cardiologist has a “special interest” in them (his words) and he thinks they’re wonderful. Yes, there are risks. But the risks to the average person of being obese are much worse.

I know that. In my first post, I said:

“While the side effects/health impacts are small when compared with the risks of obesity, they’re not necessarily small enough to be disregarded once you are at a healthy weight.”

Don’t imply I’m saying something I’m not. You don’t want to be told, fine. Other people reading this might be more interested.

LifeOfAShowGirl · 13/08/2025 17:29

PopstarPoppy · 13/08/2025 17:28

I know that. In my first post, I said:

“While the side effects/health impacts are small when compared with the risks of obesity, they’re not necessarily small enough to be disregarded once you are at a healthy weight.”

Don’t imply I’m saying something I’m not. You don’t want to be told, fine. Other people reading this might be more interested.

I’d rather be guided by multiple health professionals who have all agreed that these jabs are much better than the alternative!

OP posts:
PopstarPoppy · 13/08/2025 17:30

LifeOfAShowGirl · 13/08/2025 17:29

I’d rather be guided by multiple health professionals who have all agreed that these jabs are much better than the alternative!

If you’ve never stopped taking it, you don’t know what the alternative is! But I’m done arguing about this. The information is there if people want it.

TheRealGoose · 13/08/2025 17:36

PopstarPoppy · 13/08/2025 17:30

If you’ve never stopped taking it, you don’t know what the alternative is! But I’m done arguing about this. The information is there if people want it.

You made your point and the op made an informed decision , the same decision as I made and we are both delighted with, you don’t need to argue it , she didn’t ask you to. These are prescription medications, being used for the purpose they were prescribed. You can however start a thread warning people of the risks and obviously petition the mhra, fda, every global health authority who disagrees with you snd obviously the WHO. let us know how that goes for you.x