I'm going to make a general point about sex v gender and why it's relevant and important but I'm opting to use a non-reproductive system example.
Transgender women may be at higher risk for type 2 diabetes compared to cisgender women, but not to cisgender men, according to new research published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
It's important to understand this because of the risks involved with wider metabolic dysregulation including lower limb and circulatory disorders. Transwomen will need the same level of monitoring as the appropriate comparator group to ensure that they have adequate prevention guidance and diagnostic vigilance.
“Although more research is needed, there is little evidence that type 2 diabetes occurrence in either transgender women or transgender men is attributable to gender-affirming hormone therapy, at least in the short term,” Islam said.
Similarly, so far as is known, and this might change over time with the experience of longer-term exposure to cross-sex hormones, transmen are showing the same diabetes risk as their appropriate comparator group and not showing the risk of the acquired sex.
Extracts from this report of a study: www.endocrine.org/news-and-advocacy/news-room/2021/transgender-women-may-be-more-likely-to-have-type-2-diabetes-than-cisgender-women
Study: Noreen Islam, Rebecca Nash, Qi Zhang, Leonidas Panagiotakopoulos, Tanicia Daley, Shalender Bhasin, Darios Getahun, J Sonya Haw, Courtney McCracken, Michael J Silverberg, Vin Tangpricha, Suma Vupputuri, Michael Goodman, Is There a Link Between Hormone Use and Diabetes Incidence in Transgender People? Data From the STRONG Cohort, The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 4, April 2022, Pages e1549–e1557, doi.org/10.1210/clinem/dgab832