If I remember correctly, prof RW in QT spoke briefly about chromosomal, hormonal and genital sex. 3 sides of the same coin.
The inference being you can manipulate your hormones and genitals but not your (sex) chromosomes.
Which I presume is why many trans people who have elected to have CSH treatment and/or SRS (removal of hormone producing and responding organs) should be closely monitored. You are basically trying to overwrite your code. Mixed messages coming from the chromosomes and hormones. The body must be constantly fighting itself. Resulting in degrees of health related problems.
I am constantly in awe of our body’s capacity to keep on going no matter how much crap we feed / put it through.
I do wonder if the young drama student who was arguing on QT that you could change sex looked up who RW is after the filming?