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Weight loss injections/treatments
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Titrating down after weight loss. How long to give each dose

10 replies

Hetty428 · 17/10/2026 07:13

I’ve moved from 5mg to 2.5mg… this is my
4th week back to 2.5mg. If you’ve titrated down, how long have you given it before deciding maybe to move back up if hunger is too much?
are many of you maintaining on 2.5mg after weight loss? I don’t think I want to come off completely and think I’ll always need something even if just takes the edge off so to speak..

OP posts:
OneDayIWillLearn · 17/10/2026 12:01

I’m only dropping 0.25mg every two months so I’m going VERY slowly!! The highest I did was 5mg every 6 days, then I sat at 5mg every 7 days for a few months and now I’m at 4.75mg. I’ve just very very nervous as I have lost weight only to regain it all numerous times in the past. Ideally I’d get down to 2.5mg and then stay there for a year or so and then possibly think about coming off completely if I’ve had a steady weight for a few years then and my habits are holding up well. But I’d rather stay higher for longer than have the weight go back on myself.

WeAllHaveWings · 17/10/2026 12:15

I am down to 1.67mg (20 clicks of 5mg) now, I tend to revisit it towards the end of a pen (8-10ish weeks) and use my graph to see if weight is staying steady.

When cravings/food noise comes back I look at what and how I am eating to see if I am reverting back to old habits and try to nip them in the bud before they spiral. It usually is things like have carby dinners too regularly, or regular snacking habit sneaking in again for me. Solidly embedding those new eating habits (without thinking they are a temporary diet) is still very much a work in progress even after 2+ years on Mounjaro and 10 months in maintenance.

I’ll move back up if inflammation/sore joints return, or if weight starts trending upwards over a couple of months.

Hetty428 · 17/10/2026 14:53

WeAllHaveWings · 17/10/2026 12:15

I am down to 1.67mg (20 clicks of 5mg) now, I tend to revisit it towards the end of a pen (8-10ish weeks) and use my graph to see if weight is staying steady.

When cravings/food noise comes back I look at what and how I am eating to see if I am reverting back to old habits and try to nip them in the bud before they spiral. It usually is things like have carby dinners too regularly, or regular snacking habit sneaking in again for me. Solidly embedding those new eating habits (without thinking they are a temporary diet) is still very much a work in progress even after 2+ years on Mounjaro and 10 months in maintenance.

I’ll move back up if inflammation/sore joints return, or if weight starts trending upwards over a couple of months.

Oh interesting how are you feeling on 1.67?
is to much different from 2.5? I have RA so I think it helps with my joints too..: my rheumatologist is happy I’m on this

OP posts:
MeridaBrave · 17/10/2026 15:48

I’m doing 24 clicks of 5mg pen ie 2mg and my weight is stable on that. My next pen is 7.5mg I might try a little less, perhaps 15 clicks.

ElsieJay · 17/10/2026 15:57

I’m dosing 2.5gm weekly - 30 clicks from a 5mg pen - and weight has been stable since February.
5mg was the highest dose I ever took , but I didn’t seem to lose significantly more on it, and suffered from nausea, so much happier where I am now.

Hetty428 · 17/10/2026 17:05

ElsieJay · 17/10/2026 15:57

I’m dosing 2.5gm weekly - 30 clicks from a 5mg pen - and weight has been stable since February.
5mg was the highest dose I ever took , but I didn’t seem to lose significantly more on it, and suffered from nausea, so much happier where I am now.

how long does pen last? Do you take fifth dose too if you have a pen with it

OP posts:
Hetty428 · 17/10/2026 17:06

MeridaBrave · 17/10/2026 15:48

I’m doing 24 clicks of 5mg pen ie 2mg and my weight is stable on that. My next pen is 7.5mg I might try a little less, perhaps 15 clicks.

Is it ok to use a pen that long? I’ve been thinking to do that but cautious about using over 5 weeks for some reason lol

OP posts:
MeridaBrave · 17/10/2026 17:09

Hetty428 · 17/10/2026 17:06

Is it ok to use a pen that long? I’ve been thinking to do that but cautious about using over 5 weeks for some reason lol

It’s a risk I’m taking. It’s stored in the fridge, only take it out for the 2 mins of the weekly jab, ie inject cold. Clean the stopper each time.

WeAllHaveWings · 17/10/2026 17:34

Hetty428 · 17/10/2026 14:53

Oh interesting how are you feeling on 1.67?
is to much different from 2.5? I have RA so I think it helps with my joints too..: my rheumatologist is happy I’m on this

My aches and pains were, I assume, mostly age/menopause related.

I am feeling a bit stiff again recently when I wake and get up during the night, fine during day, but I have other stuff going on and waiting for a referral to come through so not sure what aches and pains are related to what at the moment.

I reduced from 2.08mg to 1.67mg (5 click reduction) around 6 weeks ago. I haven’t noticed any significant difference in food noise since slowly moving down from 3.75mg 10 months ago.

Tryingtothinkofausername · 17/10/2026 17:48

My highest dose was 5 mg and after a couple of months on that I dropped to 3.75 mg but found it difficult. I went back up to 5 mg for a few months then a month ago I decided to reduce again. The 3.75 mg dose feels much more manageable second time around.

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