Wegovy tablets: the possible benefit of extending the 30 minute window.

[Laska2Meryls]

I posted about this on a thead about a week ago but just posting this on a separate one because I thought that it would be useful, especially I have seen several posts from people saying that they are not feeling good appetite supression on Wegovy tablets.

I was reading about the half an hour window between taking the tablet and eating as I found some days were better than others and found an article which said that apparently the body can take up to 90 mins to fully absorb the semiglutinide. But it seems that it was decided to advise at least half an hour wait as it was felt that asking for a longer wait could be impractical for users.

Apparently even diluting it with more than a small sip of water or black tea or coffee in that time could means less absorbtion, and even a little food too early after taking it could compromise it completely.

The article did seem to be really clear on this point and well referenced. But I'm no scientist.

I do tend now to take mine early as possible (around 5.30 am) as I wake early but it could be why sometimes when I haven't waited more than an hour before drinking or eating I have felt more hunger and why some people are reporting that they are not really feeling any different on it.

Since reading this I have made a point of waiting 90 minutes and also making sure that I have well over 8hrs fasting time if possible ( we eat dinner early here) it certainly seems to work better and im steadily losing weight now on 4mg.

I'm fortunate in that I can stick to this routine without any problem as I don't have a morning schedule to keep to but appreciate that its harder if you do, but thought it may be helpful information.

I'll put up a link to the article on separately.

https://www.simpleonlinepharmacy.co.uk/health-advice/weight-loss/wegovy-pill/why-cant-i-eat-after-wegovy-pill

Here is the article.

Thanks for sharing it is very useful

This is interesting thanks @Laska2Meryls .

I’m only on the lowest starting dose at the moment (having previously used Mounjaro jabs). I haven’t noticed any suppression at all, and I had presumed the Mounjaro history had caused me to build up some sort of tolerance, but what you have said is interesting.

I’ve not found the 8 hour fast or 30 minute wait inconvenient at all really. I’ll give a 90 minute wait a try, although it might take a little bit more planning.

I’ve been taking the pill with almost exactly 120ml of water - would taking it with less water be beneficial?

Im not on it myself. But just want too add for people.. she has said the longer she goes after taking it not eating the better it is.. so I think your right..

She said sometimes she will take it then eat a couple hours later.. sometimes take the pill then wait till lunchtime.. ??? .

As I say this it not personal experience, just what a friend has said..

@ChunkyMunky Im not sure about the water amount, but the information leaflet that came with mine says a 'sip' of water ( up to 120ml) So I'd read that as 'as little as is comfortable to swallow' especially now Ive read the study I posted above.

But I suppose the amounts have been been well tested or the manufacturers wouldn't say it can be up to that amount. But it does seem (to me anyway) given what they say about how it is absorbed that maybe less water than 120ml could potentially be better? But I don't really know.

I dont measure mine but usually just take mine with a small glug of water from a glass as soon as I wake. (I don't have any problems swallowing tablets but I know some people need more to do so).

But I don't drink anything else if I can help it now since reading that info until 90 mins has passed.

(BTW I meant to say I realise that is information given by a company selling thetablets, but don't buy mine from them, it was just info I found online and seemed to make sense. )

I naturally wait 3.5 hours after waking for breakfast anyway (fits my routine) so I take my tablet first thing then wait. I will have a cup of tea an hour after, and I am losing weekly on 1.5mg. I wander if waiting to eat is helping the tablet absorb better

I read somewhere that it needs some water to dissolve the SNAC, and that they tested using between 50 - 120ml. I was originally using a full 120ml but I’ve halved that now.

I had a good long wait after the pill before eating today too (set an alarm to take it early morning then went back to sleep). I can’t say I’ve notice any suppression, but it’s been a busy day and I’ve not felt starving, so maybe something’s happening.

I think I’ll just need to plod on and see what happens.

Yesterday for the first time the tablet didn’t work at all. The only thing I did differently was I just sat up in bed a bit to take it, then lay down, instead of standing up properly (and then laying back down).

Waterwise I take a small sip, just so my mouth isn’t dry and I don’t taste the pill. Put pill on tongue, take another sip to wash it down, wait a second, then another sip. I’m waiting at least an hour after that before food or water, which seems to work well.

I saw this article too. At the time, I was seriously considering switching to Wegovy tablets from Mounjaro jabs (for reference : 2 Stone loss, 11 months maintenance at that level. No wish to lose further.)

I’d have definitely gone for a 60-90 minutes delay myself, just to see. The way I looked at it, a delay won’t make it any less effective.

But in the end, I decided that even 30 minutes was too much for me before hitting the morning coffee - so I’ve pre-ordered 2.5mg Foundayo from Asda Pharmacy.

I see there is another tablet launching with no timing issues. I might have waited a few weeks if I'd known it was coming so soon.

As above - Foundayo (Orforglipron). I’ve been wittering on about it for months. Now a reality. Looks good for maintenance, pricing looks ok.

https://onlinedoctor.asda.com/uk/foundayo.html

Foundayo will definitely outcompete the Wegovy pill, assuming it's just as effective, because of the timing issues. I'm hoping it'll lead to Wegovy having to price significantly cheaper.

I will definitely consider Foundayo once I have lost my weight. It looks much better for maintenance.
(Am hoping to lose another two stone. Which will put me a smidge under 10 stone, which is a good weight for my frame and age)

Looking at the figures, it's not quite as effective as Wegovy, although they haven't done a head to head comparison. Having already compromised on efficacy slightly for the tablet I won't be switching straight away, but as you say, it could be good for maintenance.

The last couple of days I’ve upped my wait after pills to about 90 min / 2 hours. I do think I’m starting to not feel hungry. Nothing dramatic just a subtle, Oohh I don’t really fancy that. Hopefully it lasts 🤞