MJ second time not working

[Wingingit11]

As the title suggests , I was on 15mg and loss about 5 stone. Came off for other reasons for six months, gained almost 2 stone (not helped by medical issues) and now back to 7.5 but have lost about 4 lb in total. It feels completely different to before.
Any tips?

Can’t help, but following with interest as I’m having the same problem after restarting. I’m up to 10mg now and not losing a thing. It’s a bloody expensive way to achieve nothing!

I had the same thing. It doesn’t work the same the second time. Took 18 months off again and now just taken it for the third time and still is not the same

It really is though to be fair I’m not gaining either I suppose !! Half tempted to try Wegovy for a reset but I hear that’s pretty useless so…

All the posts on reddit and here and other sites show your body gets used to a dose so you may need to get upto the same or close dose to achieve the fat loss so for 15mg you may need 12.5mg and above etc.

I think it must have to do with the previous highest dose. I had a break of almost a year and found 2.5mg effective second time round, but previously hadn't gone past 5mg and that was only for one month, having managed to lose most of my weight (only needed to lose 1.5 stone) on 2.5mg. So I think @Mysticmaiden is right and you probably need to get up to the same or close to the highest dose your body was previously used to, for the effectiveness to kick in again.

No tip but in the same boat , stopped for 2 months after going turkey at 12.5 after 4st loss (also separate reason) gained 1 st and lost the st very slowly from 2.5-10. Stalled completely on 12.5 but now on 15 mg I have lost additional 5 lb (in 4 weeks) , starting my second pen this week and just hoping 15mg will work as long as possible as ideally I want 1-1.5st more off .

although it’s painfully expensive with less results I will not go cold turkey this but tilter down slowly and probably stay on a lower dose in the long

@Bipaloss it’s so painful isn’t it. I am not one for co piracy theories but god to think how effective it used to be🤣 mine really stalled for months before I came off the first time to be honest but for me, I suppose at least it’s I am not continuing to gain on it. But please fast forward pricing to a couple of years ! I kind of see myself in it long term so climbing to 15 again is v painful ful !

You’re lsoing weight so it is working just more slowly which will happen when you have less to lose. Continue going up the dose and make sure you track your calories and protein. It will come off.

I think this is multi faceted, ancedotally people seem to have to go back to their previous dose to have effect, but I suspect first time round when we start there is a strong placebo effect, and driving desire for it to work and to lose the weight, which the second time round doesn’t exist, so you feel the real impact of the meds.

if you got all the way up to 15 they likely don’t have a big impact on you, so when you strip out the placebo effect from first time, then you likely need to get back to 15.

but the drugs are working, you need to do the heavy lifting, and proactively diet into a defecit, which you currently are not doing. You’re eating pretty close to maintenance.

getting the drugs to do the hard work will work for no one long term. I maintain on 5mg, I still get hungry, I could easily eat a large meal. But the meds allow me that control to make healthy decisions.