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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Irritability on the jabs as a side effect

10 replies

Gelatosummer · 14/07/2026 12:23

Has anyone noticed persistent irritability and shortness of temper as a side effect of the jabs? Struggling with this currently alongside loss of libido and interested to hear if it has happened to others.

OP posts:
MoneyJo · 14/07/2026 12:42

No, in fact I feel more chill and level on them. I have read of them almost acting as a mild antidepressant and that has been my experience so I'm interested to hear if others have had a more negative experience.

Gettingbysomehow · 14/07/2026 12:45

No neither symptoms and Ive been on them for two years.

jessieplat · 14/07/2026 13:00

No I’ve actually found my PMT has reduced on MJ. Could it be hormonal?

Gelatosummer · 14/07/2026 13:09

I’m struggling with it in my DH! Maybe that would have been a pertinent point to include in op but I hadn’t considered it may be gender specific. He has gone from being pretty chill to pretty spiky, and generally up for sex at any time to no interest at all. I want to support him but I’m not finding the changes ideal.

OP posts:
jessieplat · 14/07/2026 13:15

Oh interesting, I don’t know. Could it be an indirect SE if he’s not eating well? Is he lacking energy? Exercising?

Gelatosummer · 14/07/2026 13:44

He is exercising lots, but that’s normal for him. He has added in more weight training to help reduce muscle loss but that’s the only change there. He has lost a lot of weight quickly, 3 stone in 3 months so could it be food related? He is mainly eating chicken breast and salad for dinner and claims to be doing the same for lunch although I obviously don’t see that

OP posts:
putthehamsterbackinitscage · 18/07/2026 11:45

Not noticed this with DH in over 8 months.

you could try asking on Reddit- there are possibly more male posters on there? Search Mounjaro Reddit uk and it will find the relevant sections

ymemanresu · 18/07/2026 12:48

low blood sugar?

ShrankLastWinter · 18/07/2026 15:08

That’s very fast weightloss, more than a kilo a week over a sustained period, so he needs to be super careful about his nutrition whether or not that’s the problem.

Like @MoneyJo i actually find MJ rather soothing.

balozcro · 18/07/2026 15:10

I definitely have noticed that I feel low in mood for 2-3 days after having the injection. It took a few months for me to realise the pattern.

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