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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Has anyone become ill from GLP-1s?

48 replies

BeachAndSea · 27/05/2026 13:29

I wanted to ask if anyone had becoming ill or seriously after taking a weight loss injectable? So pancreatic problems, thyroid, anything like what is in the press about the risks? I so want to try it but am afraid if the risks.

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McBottle · 27/05/2026 21:43

I haven’t had side effects beyond some constipation.

I know a few people who have had more serious effects but they all went quickly to high doses and could barely eat, and I don’t think malnourishment is very good for you!

I’ve lost 5st on 2.5mg and 2 so far on 5, I don’t plan to up the dose any more.

BeachAndSea · 28/05/2026 04:39

I joined a Mounjaro for beginners FB page and there are lots of people feeling really sick though as side effects. It sounds debilitating for many and seems to matter where you inject? One woman is in casualty after her first dose saying she never been this ill.

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BeachAndSea · 28/05/2026 04:39

When people up the dose is it because you weren’t losing weight?

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Squirrelchops1 · 28/05/2026 06:38

I'd say from personal experience there's a correlation between what I've eaten and feeling nauseous. Or not enough fluids.

2.5mg isn't even a treatment dose, it's just to get your body used to it, and some people dont lose any weight.....but then some do and do well on this low level.
In all honesty the only cases of severe side effects I've heard about are people buying dodgy GLPs from their mate from the beauty salon.

Yes, as the drug becomes less effective you increase dosage. However everyone finds a sweet spot. Im 18 months in and not moved beyond 10mg and not far off goal.

PersephoneParlormaid · 28/05/2026 06:40

A lady I know had problems with her gall bladder, admitted to hospital etc, and is now waiting for it to be removed. She was told by the consultant not to go back on the jabs.

porchiepalava · 28/05/2026 07:10

BeachAndSea · 28/05/2026 04:39

I joined a Mounjaro for beginners FB page and there are lots of people feeling really sick though as side effects. It sounds debilitating for many and seems to matter where you inject? One woman is in casualty after her first dose saying she never been this ill.

What are they all eating? A lot of SE come from people chasing high suppression, hardly eating and then when they do eat it’s still the greasy kebab, just less of it. You will find plenty of people talking about the SE they have but you need to consider how they have approached the WLI.

Ultimately you don’t know how it might affect you unless you try so you just either need to go for it or not. I have OCD and thought it would literally kill me but I was in such a bad place I considered it worth the risk. I didn’t die, I lost 9 stone and it changed me life.

porchiepalava · 28/05/2026 07:12

BeachAndSea · 28/05/2026 04:39

When people up the dose is it because you weren’t losing weight?

No, far too many people move because they think you have to, or because they want that high suppression to lose weight quickly. I did over a year in the 2.5mg before moving up. Even now I only take 5mg and I have a great appetite but it keeps the drive to eat constantly at bay.

northernlight20 · 28/05/2026 07:39

op, if you are this anxious, maybe just dont take it. personally its been life changing and ive lost 9st 3lb in 14 months and now maintaining and will never come off it, but you have to fuel yourself properly and hydrate.

Notsosweetcaroline · 28/05/2026 07:49

porchiepalava · 28/05/2026 07:12

No, far too many people move because they think you have to, or because they want that high suppression to lose weight quickly. I did over a year in the 2.5mg before moving up. Even now I only take 5mg and I have a great appetite but it keeps the drive to eat constantly at bay.

I’m not sure that’s fair, you’re acting like you’re the poster child and everyone else is at fault.

peiple move becaude different doses work differently on human bodies, it’s great you could do it on 2.5, but thay dose is not a therapeutic dose , it’s a half dose to initiate treatment and get your body used to it. Many people have no impact from it, and they move up to find the one that works optimally for them.

for some that’s 2.5 and some it’s 15. I’m all for bigging youself up, but this is just ridiculous quite frankly. Sure some do, but the cost of the meds, mean many people try to make it work at a lower dose as they can’t afford the higher ones and I do wonder if you’re one of them,

porchiepalava · 28/05/2026 08:19

Notsosweetcaroline · 28/05/2026 07:49

I’m not sure that’s fair, you’re acting like you’re the poster child and everyone else is at fault.

peiple move becaude different doses work differently on human bodies, it’s great you could do it on 2.5, but thay dose is not a therapeutic dose , it’s a half dose to initiate treatment and get your body used to it. Many people have no impact from it, and they move up to find the one that works optimally for them.

for some that’s 2.5 and some it’s 15. I’m all for bigging youself up, but this is just ridiculous quite frankly. Sure some do, but the cost of the meds, mean many people try to make it work at a lower dose as they can’t afford the higher ones and I do wonder if you’re one of them,

Oh don’t be so ridiculous, I’m taking about people moving up when they don’t need to; not suggesting nobody should.

AfternoonVanessa · 28/05/2026 08:27

Yes I was admitted to hospital with an inflamed gallbladder, now removed.
However I think they are a wonder drug and have helped so many people.

Branleuse · 28/05/2026 08:29

I felt weird when I first took it and got really thirsty. eating ice lollies helped.
Had constipation at first too.
Then after that I seemed to be mostly fine until 10mg which made me feel really tired, so I went back down a dose to 7.5.

It's worth mentioning though that even initial side effects, I had good ones too in that my morning swelling in my hands and feet stopped and a lot of my general achiness improved quite quickly.

I am someone who always gets side effects for drugs and I'm a sensitive little snowflake, but I found it manageable, and could be mitigated by having a jab on a Fri so I could see how it was over the weekend.

Good time of year to try it too as it makes you feel the cold more

Linda983 · 01/06/2026 21:40

I completely understand the worry because the headlines scared me too before I started. I personally haven’t had anything serious, mostly just digestive side effects here and there. For me it’s been more about steady lifestyle changes alongside the medication rather than relying on it alone.

BeachAndSea · 02/06/2026 20:53

.afternoonvanessa. how did you end up with gallbladder removal? Were you on too high a dose?

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snowie75 · 02/06/2026 21:02

No side effects off either Wagovy or Mounjaro

NotAChanceIn · 02/06/2026 21:14

Gallbladder issues are normally associated with rapid weight loss and drastic changes in diet.

I have gallstones already. Had them from doing an 800cal diet years ago I suspect. (On reflection 4 soups at 200cal each per day weren't ideal!). I went on MJ in Dec 24, I've declared I have gallstones to providers and have followed very slow weightloss guidelines to not make my gallstones worse.

I took 2.5mg for about 4 months, then increased to 3.75mg and finally now am at 5mg. I've lost just over 5 stone doing it this way.

negative side effects:
constipation to begin with, alleviated with drinking more water.
feeling sick if I didn't eat enough or had a bit of rubbish food in the first two days after jabbing - if I prioritise protein and veg then no issues.
now on 5mg, a headache if I don't drink a lot of water on the day after the jab (2lts).
Thats it!

positive effects:
Back ache gone
BMI reduced from 44 to 26
Can run up a couple of flights of stairs no issues
General aches and pains bogged off
No gallbladder grumbling at all (used to get it pre MJ no doubt due to crap diet)
Massively improved fitness and diet.

I took a few months to decide to start it as I had concerns about it too, but I decided slow and steady and incrementally increase as needed (not every four weeks as some people did regardless of need - although that was more prevalent at the start when it wasn't quite as popular, now people are more aware of not progressing up just because the pharamcg suggests it).

Crikeyalmighty · 02/06/2026 21:20

I stopped after 5 weeks as they gave me really bad indegestion and a feeling like morning sickness but no I wasn’t ill - I just didn’t like the sensation -

Daineee · 05/06/2026 21:42

I can only speak from my experience on Mounjaro, but I haven’t had anything serious like that. I’ve had regular check-ins through my programme, which made me feel a bit more reassured at the start. Mostly it was just normal side effects that eased off after a while.

maz99 · 06/06/2026 18:23

BeachAndSea · 02/06/2026 20:53

.afternoonvanessa. how did you end up with gallbladder removal? Were you on too high a dose?

Hi, I had the same concerns as you when I started end of August last ast year... I just bit the bullet, ordered and injected 20 minutes after it was delivered... didn't overthink.

I decided tot ake tot ake MJ because I wanted help to manage my insulin resistance and blood sugar / hba1c which for the 1st time had reached a diabetes level.

Just wanted to also add that I had to have my gallbladder removed 13 years ago after losing 50lbs in 6 months with low calorie dieting... this was after never having any gallstones or gallbladder issues previously.

So, quick weight loss can cause problems
I'm currently losing on average 1lb a week, which is great for health and definitely for reducing loose skin

Daineee · 08/06/2026 21:54

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BeachAndSea · 21/06/2026 15:11

who do you check in with? a private dr?

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SilenceInside · 21/06/2026 15:19

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BeachAndSea · 21/06/2026 15:21

Wow! I have no idea about these bots or why and how they appear! Thanks for letting me know!

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