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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Injection site choice

45 replies

madeinthe80z · 11/05/2026 13:02

Hi all

Do you have a preferred injection site and why??

I’ve seen a lot of people talking about their preferred injection site, e.g. more suppression in the tummy, more consistent supression in the thighs, more side effects in the arm etc etc.

Ive done each thigh so far (only in week 2) but I’m really curious on peoples views. I’m tempted to stick to the thighs because I’ve not had too many side effects and I’m scared based on what others have said about worse side effects in different sites! Help me decide!

OP posts:
TheChosenTwo · 12/05/2026 23:23

I’ve always just done stomach, it’s easiest for me to administer. Even without much ‘wobbly fat’ anymore there’s still enough for me to inject into.
Arm looked faffy and my thighs probably have more fat on them now than my stomach but I prefer to do it lying down and I can see what I’m doing on my stomach.
Never tried anywhere else.
suppression has been stronger and weaker at various points but I put that down to more hormonal fluctuations now that I’m used to the medication rather than the site itself.

Rosetime · 13/05/2026 10:55

Why longer needles? Just curious.

The jab is meant to be subcutaneous.

SilenceInside · 13/05/2026 11:22

@Rosetime 6 and 8mm needles are still subcutaneous. I personally haven’t noticed a difference between 4, 6 or 8mm but I guess some people might.

MsSquiz · 13/05/2026 11:41

I’ve been on Mounjaro for over a year and used various sites.

I’ve had very little effect when using my stomach.
my arm had the best effect but is awkward, so I usually use my thighs but find they bruise (I do bruise easily on my legs!) so I tend to switch to arms when I’m on the run up to wearing a swimming costume for example so the bruising isn’t obviously

HeidiLite · 13/05/2026 11:54

There have been studies about peptide injection sites that showed injection site-dependent absoption - abdomen tended to absorb somewhat faster than the thigh. Considering GLP-1s are long-acting, the differences are not major and overall absorption will be similar, but indeed you may feel a difference.

Rosetime · 13/05/2026 11:55

SilenceInside · 13/05/2026 11:22

@Rosetime 6 and 8mm needles are still subcutaneous. I personally haven’t noticed a difference between 4, 6 or 8mm but I guess some people might.

Yeah, i use the 4mm and 6mm. Haven't noticed any difference. Don't think the 8mm would be much different to the 6mm.
But someone mentioned a 12mm.
Just curious why the need for longer needles. If 4mm is good enough and is thinner (32g), why the longer needles? What makes them less painful?

SilenceInside · 13/05/2026 12:08

I don't think I'd want to use a 12mm needle, I think that would trigger my latent needle phobia!

As far as I can tell, the differences people discuss wrt to needle length isn't about pain, but about site reactions and/or absorption of the medication.

twilightcafe · 15/05/2026 15:40

I jabbed an inner thigh this week for a change. Could be imagining things, but suppression is definitely higher than when I usually jab in my stomach.

JanetCollingwood · 25/05/2026 21:43

This reply has been deleted

This has been deleted by MNHQ for breaking our Talk Guidelines.

Ismo456 · 25/05/2026 22:30

Following as I did my first jab last week (stomach) and had horrendous nausea.

due my 2nd jab tonight but can’t face putting myself through 5 days of sickness again.

maybe I should try my thigh this time?

where abouts in the thigh do you jab?

missspent · 25/05/2026 22:31

I believe I read that across a large number of people there is no one better site, but that anecdotally individuals can have a site that works best for them. I always inject left hand side of stomach as I used to alternate and found had good week/bad week so now stick to different parts of one side. It could all be in my head but maintaining now after 5 stone loss

AgnesMcDoo · 25/05/2026 22:50

I don’t think it makes any difference.

I do tummy

madeinthe80z · 26/05/2026 05:03

Ismo456 · 25/05/2026 22:30

Following as I did my first jab last week (stomach) and had horrendous nausea.

due my 2nd jab tonight but can’t face putting myself through 5 days of sickness again.

maybe I should try my thigh this time?

where abouts in the thigh do you jab?

There’s a diagram in the leaflet showing the zone. I jab at the inner top of my thing in the nice wobbly bit!

OP posts:
ChristmasStars · 26/05/2026 05:07

Ismo456 · 25/05/2026 22:30

Following as I did my first jab last week (stomach) and had horrendous nausea.

due my 2nd jab tonight but can’t face putting myself through 5 days of sickness again.

maybe I should try my thigh this time?

where abouts in the thigh do you jab?

Did you do your second jab? If not maybe consider halving the dose? That's what my DH did.

Ismo456 · 26/05/2026 07:16

ChristmasStars · 26/05/2026 05:07

Did you do your second jab? If not maybe consider halving the dose? That's what my DH did.

Edited

no I didn’t. I started a new thread re this last night and a few others have said this

did the half dose sit better with your DH side effect wise? And did he still lose?

ChristmasStars · 26/05/2026 07:47

Ismo456 · 26/05/2026 07:16

no I didn’t. I started a new thread re this last night and a few others have said this

did the half dose sit better with your DH side effect wise? And did he still lose?

Yes. He didn't stay on it long but long enough to adjust.

NoTouch · 26/05/2026 07:52

I have always injected in stomach and the effects can still vary week to week.

I think for the majority of people injection site doesn’t make a significant difference and any changes might be coincidental.

Perianth · 26/05/2026 08:44

twilightcafe · 15/05/2026 15:40

I jabbed an inner thigh this week for a change. Could be imagining things, but suppression is definitely higher than when I usually jab in my stomach.

I considered doing this but checked online and advice is to avoid inner thigh as there are more nerves and blood vessels in that area, so I went to top surface of my thigh, but oof, skin is tough there compared to my belly. Back to that for the next shot!

twilightcafe · 26/05/2026 09:11

Perianth · 26/05/2026 08:44

I considered doing this but checked online and advice is to avoid inner thigh as there are more nerves and blood vessels in that area, so I went to top surface of my thigh, but oof, skin is tough there compared to my belly. Back to that for the next shot!

Oh, is it? Thanks for the heads-up.

HeidiLite · 26/05/2026 10:54

ButterYellowFlowers · 12/05/2026 23:18

Nonsense. I was able to inject my biological medication into my stomach at a size 6. If you had 0 fat you’d be dead.

LOL I missed this, a person on internet knows better than me how much subcutaneous fat I have on my stomach, amazing

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