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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

retatrutide new weight loss drug

79 replies

ElephantGrey101 · 19/04/2026 08:16

Most of my family are on GLPs. A couple of them are on a new drug called retatrutide. This is meant to be a better version of things like Monjouro and has fewer side effects and you retain more of your muscle etc.

However, it doesn’t seem to be available officially anywhere as it is still in clinical trials. They are buying it from someone at the gym.

Does anyone have any experience of this drug?

OP posts:
PokHas · 23/04/2026 12:16

mantez · 21/04/2026 09:03

It will soon become very fashionable not to take them, and unfashionable to be skinny with hanging skin and muscle wastage.

Before semaglutides, being skinny was good, fat (even a little bit) was bad. Now if you are looking skinny weight wise, well you MUST be taking the stuff!

The herd mentality will reverse eventually apart from those who are morbidly obese, which is what it was intended for in the first place.

Maybe people are doing WLIs for their health, not fashion…

Girlintheframe · 23/04/2026 12:56

JMSA · 23/04/2026 10:49

I’ve loved Mounjaro but would be very interested in an alternative that’s possibly more effective (and cheaper?). I still have to rely on willpower a lot as despite being on the highest dose, I could do with better appetite suppression.

From what I’ve seen on SM, MJ has better appetite suppression although from what I gather this peptide is better overall (sorry I’ve no idea how it works in any detail) as it affects other receptors.

Jellybelly80 · 23/04/2026 13:10

Seilean · 21/04/2026 09:16

Thats so weird, I'm sure I remembered her getting it from somewhere else, I sit corrected.

I always felt there was more to this ladies health than had been reported in the media.

TheChosenTwo · 23/04/2026 15:14

MrsTravelBug · 23/04/2026 11:07

People have bought illegal substances from gyms since the dawn of time, every gym I have been a member of has had a side hustle in steroids, they are just expanding their market. It’s hardly a new phenomenon.

I’ve only ever been a member of a David Lloyd gym and it’s a very ‘naice’ branch - never noticed anyone being shady and potentially selling this in there!
where are all these gyms selling dodgy stuff?
I’m not asking for myself or a friend, I’m happy paying for my monthly MJ thanks, just very intrigued… 😂

Sunnyskiesa · 23/04/2026 16:52

whatifs1 · 23/04/2026 10:26

or they do both? 😆

Not really… retatrutide is still experimental meaning its long-term safety and effectiveness are still being studied which is exactly what clinical trials are for.
COVID-19 vaccines went through full Phase 1-3 trials with tens of thousands of participants then were independently reviewed by the MHRA. After approval, they were given to millions of people, creating one of the most extensive safety datasets ever gathered.
Retatrutide has far less evidence, while COVID vaccines are among the most scrutinised medical products in history.

MrsTravelBug · 23/04/2026 17:52

TheChosenTwo · 23/04/2026 15:14

I’ve only ever been a member of a David Lloyd gym and it’s a very ‘naice’ branch - never noticed anyone being shady and potentially selling this in there!
where are all these gyms selling dodgy stuff?
I’m not asking for myself or a friend, I’m happy paying for my monthly MJ thanks, just very intrigued… 😂

Definitely not David Lloyd, well at least I wouldn’t think so? I train at sweaty body builder gyms, the ones with iron machines and pictures of arnie on the walls or boxing gyms.

whatifs1 · 23/04/2026 18:17

Sunnyskiesa · 23/04/2026 16:52

Not really… retatrutide is still experimental meaning its long-term safety and effectiveness are still being studied which is exactly what clinical trials are for.
COVID-19 vaccines went through full Phase 1-3 trials with tens of thousands of participants then were independently reviewed by the MHRA. After approval, they were given to millions of people, creating one of the most extensive safety datasets ever gathered.
Retatrutide has far less evidence, while COVID vaccines are among the most scrutinised medical products in history.

I was referring to the comment that said people that take peptides probably wouldn’t/didn’t take the Covid jab.

TheChosenTwo · 23/04/2026 19:55

MrsTravelBug · 23/04/2026 17:52

Definitely not David Lloyd, well at least I wouldn’t think so? I train at sweaty body builder gyms, the ones with iron machines and pictures of arnie on the walls or boxing gyms.

Ah fair enough, I was prepared to be on the look out for shady goings on 😂

MeridaBrave · 23/04/2026 20:33

MrsTravelBug · 23/04/2026 17:52

Definitely not David Lloyd, well at least I wouldn’t think so? I train at sweaty body builder gyms, the ones with iron machines and pictures of arnie on the walls or boxing gyms.

My gym is not David Lloyd but not so different vibe and I’m a regular who lifts and I was approached by the maintenance man and asked if I wanted.

Girlintheframe · 24/04/2026 08:46

You don’t need a shady gym, you can buy it online. Where it’s coming from I’m not sure but it’s not hard to get hold of.

MeridaBrave · 06/05/2026 11:12

Girlintheframe · 24/04/2026 08:46

You don’t need a shady gym, you can buy it online. Where it’s coming from I’m not sure but it’s not hard to get hold of.

It won’t be genuine retatrutide

HeidiLite · 06/05/2026 11:41

You don’t need a shady gym, you can buy it online

Not any less shady.

QuestionablePeptideChoices · 06/05/2026 14:30

MeridaBrave · 06/05/2026 11:12

It won’t be genuine retatrutide

It won't have the Lilly label on, that's for sure, but the peptide sequence and lipid side chain modifications are well known, so the Chinese labs are churning it out like any other generic drug.

Crwysmam · 06/05/2026 14:47

OneThirdLess · 21/04/2026 09:28

This isn't a defence, but it's not illegal to take them. It also isn't illegal to sell them, because they're advertised as "for research purposes only and not for human consumption". Which is what makes them grey market, not black market.

I'd rather everyone had safe access! And I take mounjaro on a prescription, I'm way too risk averse to try anything else. But my understanding is that the peptides aren't all that difficult to make if you have the lab setup - which a lot of places in China (etc) do as they already make peptides legitimately for medicine companies.

So people taking grey market peptides are taking a risk - but it probably isn't as big a risk as we might think. Given how widespread they've become, there would be a lot more horror stories if they were all dodgy. In a way, that's more worrying - because they're becoming more popular so if a bad batch gets out, there could be a lot more harm done to more people, and there's no comeback on the manufacturer. For me that's a much bigger concern.

It is illegal unless you are licensed to buy the drug for use for experimental purposes ie cell lines. There are very strict guidelines regarding experimental drugs in whole humans and animals for that matter. Yes you can buy it and sell it but not to experiment on gullible customers.

Crwysmam · 06/05/2026 14:55

TheChosenTwo · 23/04/2026 15:14

I’ve only ever been a member of a David Lloyd gym and it’s a very ‘naice’ branch - never noticed anyone being shady and potentially selling this in there!
where are all these gyms selling dodgy stuff?
I’m not asking for myself or a friend, I’m happy paying for my monthly MJ thanks, just very intrigued… 😂

It’s actually not sold in gyms as a weight loss drug but as a method of losing fat by body builders so the can define muscle groups. It’s very popular with young adult males to help shift the puppy fat. It’s marketed as a peptide and probably quite dangerous when used in conjunction with other so called peptides.

There is currently an American body builder on TicTok who has had catastrophic damage to his heart as a result of using a cocktail of black market supplements. He’s been in hospital for over 12 months and bares no resemblance to his former self.

Using any unregulated and untested drug will have consequences.

MeridaBrave · 06/05/2026 15:47

QuestionablePeptideChoices · 06/05/2026 14:30

It won't have the Lilly label on, that's for sure, but the peptide sequence and lipid side chain modifications are well known, so the Chinese labs are churning it out like any other generic drug.

Sure. That may well be true. But who knows really.

But would be worried about contamination, how long it would last for. The way it needs to be reconstituted and further risks (real Mounjaro is stable until expiry date in the fridge etc).

Why take the risk when you can buy Mounjaro from EL from licensed pharmacy?

QuestionablePeptideChoices · 06/05/2026 16:17

MeridaBrave · 06/05/2026 15:47

Sure. That may well be true. But who knows really.

But would be worried about contamination, how long it would last for. The way it needs to be reconstituted and further risks (real Mounjaro is stable until expiry date in the fridge etc).

Why take the risk when you can buy Mounjaro from EL from licensed pharmacy?

Starter dose of Mounjaro - about £135/month? Is that right? So about £1620 a year? Grey market retatrutide, about £55/year, plus about the same for the cost of the syringes and the BAC water to reconstitute it. Yes, there are concerns around safety and it's illegal to import an unlicensed medicine, but there's an obvious reason that people are choosing this stuff.

SilenceInside · 06/05/2026 16:41

It's obvious that it's cheaper, because there are absolutely no checks or regulations being upheld, and so it could be anything in any state. Some people will take that risk because they are desperate to lose weight or whatever other benefit they are desperate for. Other people it will be down to total ignorance and an element of stupidity or poor judgement of risk. A few it will be because of an attitude that rules and regs don't need to apply to them, the attitude that anyone who will only buy from a legitimate source is an unthinking rule-compliant person.

JMSA · 06/05/2026 20:11

I wouldn’t risk it, but I do wish there was a legit cheaper option 😕

MeridaBrave · 06/05/2026 20:41

QuestionablePeptideChoices · 06/05/2026 16:17

Starter dose of Mounjaro - about £135/month? Is that right? So about £1620 a year? Grey market retatrutide, about £55/year, plus about the same for the cost of the syringes and the BAC water to reconstitute it. Yes, there are concerns around safety and it's illegal to import an unlicensed medicine, but there's an obvious reason that people are choosing this stuff.

Edited

So half that as I’m using a 5mg pen to take 2mg but yes. £160 a pen and each is lasting circa 10 weeks. Once the golden dose is gone each pen will only last 8 weeks. But yes illegal peptides are much cheaper.

JulietteHasAGun · 06/05/2026 22:19

MeridaBrave · 06/05/2026 20:41

So half that as I’m using a 5mg pen to take 2mg but yes. £160 a pen and each is lasting circa 10 weeks. Once the golden dose is gone each pen will only last 8 weeks. But yes illegal peptides are much cheaper.

Do they let you order only once every ten weeks?

MeridaBrave · 06/05/2026 22:37

JulietteHasAGun · 06/05/2026 22:19

Do they let you order only once every ten weeks?

I can order every 7/8 weeks so I’m getting a little ahead. At some point I’ll take a gap - downside is if I want to restart I’ll need to do one 2.5mg pen.

Girlintheframe · 07/05/2026 09:28

SilenceInside · 06/05/2026 16:41

It's obvious that it's cheaper, because there are absolutely no checks or regulations being upheld, and so it could be anything in any state. Some people will take that risk because they are desperate to lose weight or whatever other benefit they are desperate for. Other people it will be down to total ignorance and an element of stupidity or poor judgement of risk. A few it will be because of an attitude that rules and regs don't need to apply to them, the attitude that anyone who will only buy from a legitimate source is an unthinking rule-compliant person.

From what I’ve seen you can get it checked. There are details on Reddit about where you send it to and they check what exactly is in the compound you’ve been sent. From what I gather it’s expensive tho. There are some companies that have done the checks already and have certificates of authentication on their websites.
Reading about it on Reddit the ones buying it direct from china are getting it for practically pennies! It’s much more expensive if bought through a 3rd party, but then often the 3rd party has the authentication certificate so swings and roundabouts I suppose

SilenceInside · 07/05/2026 09:38

How would anyone think that a website posting a "certificate of authentication" on their website means anything at all in relation to what you might be sent. Insane.

Getting each dubious vial tested in a lab yourself seems like a mad overhead just to make sure you're not injecting yourself with insulin, or double strength semaglutide - both of which have been found to be the medication in black market GLP1s. Or bacteria, or other contaminants.

Girlintheframe · 07/05/2026 09:45

SilenceInside · 07/05/2026 09:38

How would anyone think that a website posting a "certificate of authentication" on their website means anything at all in relation to what you might be sent. Insane.

Getting each dubious vial tested in a lab yourself seems like a mad overhead just to make sure you're not injecting yourself with insulin, or double strength semaglutide - both of which have been found to be the medication in black market GLP1s. Or bacteria, or other contaminants.

From what I gather, you find others who have the same batch number as you and you club together to get it checked. The stuff coming from china is so cheap that I suppose people can afford to do that. I find the whole thing fascinating tbh. Wasn’t until I found TikTok and bodybuilding content that this whole other world popped up!

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