MJ not working second time around

[BoringBoard]

I was on Mounjaro last year for a few months. It worked instantly. I had to reduce the initital dose to 1.25mg because 2.5mg completely took away my appetite. I was on 2.5mg for months and I never got beyond 3.75mg.

I'm back on it after a 5 month break and the 2.5mg is doing very little. It’s a totally different experience. I’ve only been back on it 2 and a bit weeks and already keen to get on to 5mg.

Anyone else had this?

2.5 did very little for me - It was only when I moved up doses I felt the suppression - this dose is really to prepare your body and and the higher doses will give you the results you need. I'd stick with it - 3 stone down and just come off MJ !

@BoringBoard interested, did you come off it because you'd hit goal or the prices? Did you put weight back on? I want to come off it, but I tried a couple of times, not for long though, and felt awful, I only take a small dose and find it does the trick till day 5,same as always.

@Meladrami came off it because I had hit my target. I have mostly kept the weight off but the secondary benefits of MJ are so great to me that I am back on it. It was a huge cure for my PMDD and racing thoughts. I have gone back on under a maintenance programme.

this time it’s almost like im not taking it.

How long were you on it? My view is the mind is hugely powerful and if we believe it works Ir does, but as time goes on, or on second round, the mind is not deceived and the real impact is felt.

I've read lots of comments that second time around people have to go up to at least their previous high dose before it kicks in and quite a few have had to go several doses higher.

I've no real life experience as I'm on my first journey with Mounjaro but have read it often enough to think it's probably a thing, much like switching from one type of GLP to another doesn't seem to hit the same.